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Phosphorylation Governs Assembly of a Multi-Stress Sensor: Investigating Stressosome Assembly
Phosphorylation Governs Assembly of a Multi-Stress Sensor: Investigating Stressosome Assembly
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211153034
- ISBN
- 9798346877608
- DDC
- 574
- 서명/저자
- Phosphorylation Governs Assembly of a Multi-Stress Sensor: Investigating Stressosome Assembly
- 발행사항
- [Sl] : University of California, San Francisco, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 72 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-06, Section: B.
- 주기사항
- Advisor: Booth, David.
- 학위논문주기
- Thesis (Ph.D.)--University of California, San Francisco, 2024.
- 초록/해제
- 요약Pathogenic bacteria rely on a myriad of survival mechanisms to successfully establish their infection niche. This includes methods of immune evasion, nutrient switching, and environmental adaptation. In Listeria monocytogenes, the causative agent of listeriosis, environmental adaptation is regulated by a macromolecular machine known as the stressosome. The stressosome is a megadalton cytosolic protein complex that geometrically takes on a pseudo-icosahedron. Comprised primarily of multiple copies of three proteins RsbR, RsbS and a kinase RsbT, the stressosome is responsible for sensing changes in pH, salt, ethanol, and light. Stressosome activation and assembly are tightly linked to phosphorylation state; however, we have limited information about how phosphorylation impacts the stressosome structurally. Here in Chapter 1, I will provide a brief introduction into my PhD project, in Chapter 2, I will present my findings on the role of phosphorylation in stressosome assembly, and finally in Chapter 3, I will share preliminary work on stressosome assembly related to a phosphatase, RsbX.
- 일반주제명
- Biochemistry
- 일반주제명
- Cellular biology
- 일반주제명
- Biology
- 일반주제명
- Molecular biology
- 키워드
- Phosphorylation
- 키워드
- Stress response
- 키워드
- Stressosome
- 기타저자
- University of California, San Francisco Biochemistry and Molecular Biology
- 기본자료저록
- Dissertations Abstracts International. 86-06B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798346877608
■035 ▼a(MiAaPQ)AAI31637378
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aBond, Elizabeth A.▼0(orcid)0000-0002-8671-9504
■24510▼aPhosphorylation Governs Assembly of a Multi-Stress Sensor: Investigating Stressosome Assembly
■260 ▼a[Sl]▼bUniversity of California, San Francisco▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a72 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-06, Section: B.
■500 ▼aAdvisor: Booth, David.
■5021 ▼aThesis (Ph.D.)--University of California, San Francisco, 2024.
■520 ▼aPathogenic bacteria rely on a myriad of survival mechanisms to successfully establish their infection niche. This includes methods of immune evasion, nutrient switching, and environmental adaptation. In Listeria monocytogenes, the causative agent of listeriosis, environmental adaptation is regulated by a macromolecular machine known as the stressosome. The stressosome is a megadalton cytosolic protein complex that geometrically takes on a pseudo-icosahedron. Comprised primarily of multiple copies of three proteins RsbR, RsbS and a kinase RsbT, the stressosome is responsible for sensing changes in pH, salt, ethanol, and light. Stressosome activation and assembly are tightly linked to phosphorylation state; however, we have limited information about how phosphorylation impacts the stressosome structurally. Here in Chapter 1, I will provide a brief introduction into my PhD project, in Chapter 2, I will present my findings on the role of phosphorylation in stressosome assembly, and finally in Chapter 3, I will share preliminary work on stressosome assembly related to a phosphatase, RsbX.
■590 ▼aSchool code: 0034.
■650 4▼aBiochemistry
■650 4▼aCellular biology
■650 4▼aBiology
■650 4▼aMolecular biology
■653 ▼aListeria monocytogenes
■653 ▼aPhosphorylation
■653 ▼aStress response
■653 ▼aStressosome
■653 ▼aStructural biology
■690 ▼a0487
■690 ▼a0379
■690 ▼a0306
■690 ▼a0307
■71020▼aUniversity of California, San Francisco▼bBiochemistry and Molecular Biology.
■7730 ▼tDissertations Abstracts International▼g86-06B.
■790 ▼a0034
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17164710▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
