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Quantification of Musculoskeletal Structural Adaptations Underlying Functional Deficits in Children and Young Adults with Hemiparetic Cerebral Palsy
Quantification of Musculoskeletal Structural Adaptations Underlying Functional Deficits in Children and Young Adults with Hemiparetic Cerebral Palsy
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211153036
- ISBN
- 9798346858713
- DDC
- 610
- 저자명
- Joshi, Divya.
- 서명/저자
- Quantification of Musculoskeletal Structural Adaptations Underlying Functional Deficits in Children and Young Adults with Hemiparetic Cerebral Palsy
- 발행사항
- [Sl] : Northwestern University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 146 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-06, Section: B.
- 주기사항
- Advisor: Dewald, Julius;Ingo, Carson.
- 학위논문주기
- Thesis (Ph.D.)--Northwestern University, 2024.
- 초록/해제
- 요약Cerebral palsy (CP), the most common movement disorder in childhood, results in progressive limitations in the functional use of the affected limbs. Structural mechanisms at the musculoskeletal level are believed to contribute to functional deficits such as weakness and altered biomechanical properties, particularly in distal joints such as the hand and fingers; however, there is currently limited understanding of this relationship. This dissertation presents a comprehensive investigation of in vivo musculoskeletal adaptations that affect hand and finger function in children and young adults with hemiparetic cerebral palsy (HCP) by using advanced diffusion tensor imaging (DTI) techniques in conjunction with novel mechatronic measurements.First, I completed a sensitivity analysis to determine the optimal DTI parameters that robustly quantified in vivo upper extremity muscle morphology, discovering that probabilistic tractography was superior to deterministic methods in accurately characterizing muscle architecture. Then, I applied these optimized DTI parameters to examine adaptations in forearm flexor muscles of individuals with HCP, finding that significant interlimb differences in muscle size, muscle fiber geometry, and DTI diffusivity profiles contributed substantially to grip strength deficits. Finally, I explored the relationship between DTI-derived measures and passive properties in the wrist and finger joints, showing that increased passive torques during extreme hand extension correlate withreduced diffusivity.Collectively, these findings deepen our understanding of secondary musculoskeletal changes following a brain injury at birth and underscore the need for targeted interventions aimed at addressing structural and associated functional impairments in individuals with CP. This work lays the foundation for future research aimed at improving motor function through integrated imaging and biomechanical assessments of the musculoskeletal system in individuals with HCP.
- 일반주제명
- Biomedical engineering
- 일반주제명
- Neurosciences
- 일반주제명
- Medical imaging
- 일반주제명
- Physiology
- 키워드
- Cerebral palsy
- 키워드
- Passive torque
- 키워드
- Skeletal muscles
- 기타저자
- Northwestern University Biomedical Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-06B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798346858713
■035 ▼a(MiAaPQ)AAI31638105
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a610
■1001 ▼aJoshi, Divya.▼0(orcid)0000-0001-6397-0037
■24510▼aQuantification of Musculoskeletal Structural Adaptations Underlying Functional Deficits in Children and Young Adults with Hemiparetic Cerebral Palsy
■260 ▼a[Sl]▼bNorthwestern University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a146 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-06, Section: B.
■500 ▼aAdvisor: Dewald, Julius;Ingo, Carson.
■5021 ▼aThesis (Ph.D.)--Northwestern University, 2024.
■520 ▼aCerebral palsy (CP), the most common movement disorder in childhood, results in progressive limitations in the functional use of the affected limbs. Structural mechanisms at the musculoskeletal level are believed to contribute to functional deficits such as weakness and altered biomechanical properties, particularly in distal joints such as the hand and fingers; however, there is currently limited understanding of this relationship. This dissertation presents a comprehensive investigation of in vivo musculoskeletal adaptations that affect hand and finger function in children and young adults with hemiparetic cerebral palsy (HCP) by using advanced diffusion tensor imaging (DTI) techniques in conjunction with novel mechatronic measurements.First, I completed a sensitivity analysis to determine the optimal DTI parameters that robustly quantified in vivo upper extremity muscle morphology, discovering that probabilistic tractography was superior to deterministic methods in accurately characterizing muscle architecture. Then, I applied these optimized DTI parameters to examine adaptations in forearm flexor muscles of individuals with HCP, finding that significant interlimb differences in muscle size, muscle fiber geometry, and DTI diffusivity profiles contributed substantially to grip strength deficits. Finally, I explored the relationship between DTI-derived measures and passive properties in the wrist and finger joints, showing that increased passive torques during extreme hand extension correlate withreduced diffusivity.Collectively, these findings deepen our understanding of secondary musculoskeletal changes following a brain injury at birth and underscore the need for targeted interventions aimed at addressing structural and associated functional impairments in individuals with CP. This work lays the foundation for future research aimed at improving motor function through integrated imaging and biomechanical assessments of the musculoskeletal system in individuals with HCP.
■590 ▼aSchool code: 0163.
■650 4▼aBiomedical engineering
■650 4▼aNeurosciences
■650 4▼aMedical imaging
■650 4▼aPhysiology
■653 ▼aCerebral palsy
■653 ▼aDiffusion tensor imaging
■653 ▼aMagnetic resonance imaging
■653 ▼aPassive torque
■653 ▼aPediatric hemiplegia
■653 ▼aSkeletal muscles
■690 ▼a0541
■690 ▼a0317
■690 ▼a0574
■690 ▼a0719
■71020▼aNorthwestern University▼bBiomedical Engineering.
■7730 ▼tDissertations Abstracts International▼g86-06B.
■790 ▼a0163
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17164727▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
