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Investigating the Effect of Sidechain Packing on Membrane Protein Association
Investigating the Effect of Sidechain Packing on Membrane Protein Association
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152829
- ISBN
- 9798384054290
- DDC
- 574.191
- 서명/저자
- Investigating the Effect of Sidechain Packing on Membrane Protein Association
- 발행사항
- [Sl] : The University of Wisconsin - Madison, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 183 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Senes, Alessandro.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2024.
- 초록/해제
- 요약Membrane protein folding occurs as a result of an equilibrium of biophysical forces. Polar and charged interactions can drive folding within the hydrophobic environment of the membrane. The stabilizing effects of sidechain packing on membrane protein folding were deduced in a variety of foundational bacteriorhodopsin studies, and sidechain packing as a driving force has been demonstrated through modern protein re-design of phospholamban. However, the extent at which packing can act as a driving force in general in membrane protein systems is not well understood. We investigate the impact of sidechain packing on membrane protein association by using computational design. By sampling dimer conformations from the PDB, we designed hundreds of sequences that self-associate. Structural characterization through mutations on these proteins suggests that packing is a weak driving force in a variety of membrane protein systems.
- 일반주제명
- Biophysics
- 일반주제명
- Computational physics
- 일반주제명
- Bioinformatics
- 일반주제명
- Biochemistry
- 키워드
- Membrane protein
- 키워드
- Phospholamban
- 기타저자
- The University of Wisconsin - Madison Biochemistry-ALS
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211152829
■006m o d
■007cr#unu||||||||
■020 ▼a9798384054290
■035 ▼a(MiAaPQ)AAI31560386
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574.191
■1001 ▼aLoiseau, Gilbert Jamilla.
■24510▼aInvestigating the Effect of Sidechain Packing on Membrane Protein Association
■260 ▼a[Sl]▼bThe University of Wisconsin - Madison▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a183 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Senes, Alessandro.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2024.
■520 ▼aMembrane protein folding occurs as a result of an equilibrium of biophysical forces. Polar and charged interactions can drive folding within the hydrophobic environment of the membrane. The stabilizing effects of sidechain packing on membrane protein folding were deduced in a variety of foundational bacteriorhodopsin studies, and sidechain packing as a driving force has been demonstrated through modern protein re-design of phospholamban. However, the extent at which packing can act as a driving force in general in membrane protein systems is not well understood. We investigate the impact of sidechain packing on membrane protein association by using computational design. By sampling dimer conformations from the PDB, we designed hundreds of sequences that self-associate. Structural characterization through mutations on these proteins suggests that packing is a weak driving force in a variety of membrane protein systems.
■590 ▼aSchool code: 0262.
■650 4▼aBiophysics
■650 4▼aComputational physics
■650 4▼aBioinformatics
■650 4▼aBiochemistry
■653 ▼aComputational design
■653 ▼aMembrane protein
■653 ▼aSidechain packing
■653 ▼aVan der Waals packing
■653 ▼aPhospholamban
■690 ▼a0786
■690 ▼a0216
■690 ▼a0715
■690 ▼a0487
■71020▼aThe University of Wisconsin - Madison▼bBiochemistry-ALS.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17164080▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
