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The Structure of Fitness Landscapes Across Genotypes and Environments
The Structure of Fitness Landscapes Across Genotypes and Environments
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152833
- ISBN
- 9798346533382
- DDC
- 574
- 서명/저자
- The Structure of Fitness Landscapes Across Genotypes and Environments
- 발행사항
- [Sl] : Harvard University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 251 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-05, Section: B.
- 주기사항
- Advisor: Desai, Michael M.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2024.
- 초록/해제
- 요약Over the last 20 years, advances in experimental genetics have allowed us to map fitness landscapes at a scale and resolution that the likes of Fisher, Haldane, and Wright could not have even dreamed of a hundred years ago. These cutting-edge experimental methods have empowered us to try and understand the features of the evolutionary process in the wild by using experiments in the lab. In this dissertation, I will describe three such experimental projects that I undertook to map the fitness landscape across many different genotypes and environments in budding yeast.In chapter 2, I describe the process of molecular and phenotypic adaptation in the longest-running laboratory evolution experiment in budding yeast. In chapter 3, I report work in which we constructed, genotyped, and phenotyped ≈ 100,000 F1 offspring from a budding yeast cross and mapped the highly polygenic and epistatic fitness landscape in different environments at a resolution ≈ 10 times better than the previous state of the art. In chapter 4, I detail further experiments using the 100,000 F1 offspring where we measured their fitness in an extremely large panel of structured environments to understand the pleiotropic structure across environments and used it to map the functional organization of the cell. Finally, in chapter 5, I briefly summarize our results and mention promising future avenues for this body of work.
- 일반주제명
- Biology
- 일반주제명
- Cellular biology
- 일반주제명
- Molecular biology
- 일반주제명
- Genetics
- 키워드
- Genotypes
- 기타저자
- Harvard University Biology Molecular and Cellular
- 기본자료저록
- Dissertations Abstracts International. 86-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798346533382
■035 ▼a(MiAaPQ)AAI31560747
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aGopalakrishnan, Shreyas.▼0(orcid)0000-0002-7243-0005
■24510▼aThe Structure of Fitness Landscapes Across Genotypes and Environments
■260 ▼a[Sl]▼bHarvard University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a251 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-05, Section: B.
■500 ▼aAdvisor: Desai, Michael M.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2024.
■520 ▼aOver the last 20 years, advances in experimental genetics have allowed us to map fitness landscapes at a scale and resolution that the likes of Fisher, Haldane, and Wright could not have even dreamed of a hundred years ago. These cutting-edge experimental methods have empowered us to try and understand the features of the evolutionary process in the wild by using experiments in the lab. In this dissertation, I will describe three such experimental projects that I undertook to map the fitness landscape across many different genotypes and environments in budding yeast.In chapter 2, I describe the process of molecular and phenotypic adaptation in the longest-running laboratory evolution experiment in budding yeast. In chapter 3, I report work in which we constructed, genotyped, and phenotyped ≈ 100,000 F1 offspring from a budding yeast cross and mapped the highly polygenic and epistatic fitness landscape in different environments at a resolution ≈ 10 times better than the previous state of the art. In chapter 4, I detail further experiments using the 100,000 F1 offspring where we measured their fitness in an extremely large panel of structured environments to understand the pleiotropic structure across environments and used it to map the functional organization of the cell. Finally, in chapter 5, I briefly summarize our results and mention promising future avenues for this body of work.
■590 ▼aSchool code: 0084.
■650 4▼aBiology
■650 4▼aCellular biology
■650 4▼aMolecular biology
■650 4▼aGenetics
■653 ▼aExperimental evolution
■653 ▼aQuantitative genetics
■653 ▼aPhenotypic adaptation
■653 ▼aGenotypes
■690 ▼a0306
■690 ▼a0379
■690 ▼a0369
■690 ▼a0307
■71020▼aHarvard University▼bBiology, Molecular and Cellular.
■7730 ▼tDissertations Abstracts International▼g86-05B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17164110▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
