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Studies in Natural Product Discovery and Total Synthesis: Towards (1) Tambromycin and Analogs and (2) Cysteine Containing Natural Products
Studies in Natural Product Discovery and Total Synthesis: Towards (1) Tambromycin and Analogs and (2) Cysteine Containing Natural Products
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151131
- ISBN
- 9798382757735
- DDC
- 547
- 서명/저자
- Studies in Natural Product Discovery and Total Synthesis: Towards (1) Tambromycin and Analogs and (2) Cysteine Containing Natural Products
- 발행사항
- [Sl] : Northwestern University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 137 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
- 주기사항
- Advisor: Thomson, Regan J.;Kelleher, Neil.
- 학위논문주기
- Thesis (Ph.D.)--Northwestern University, 2024.
- 초록/해제
- 요약Natural products and their synthetic analogs have historically been a major contributor for the treatment of disease. Organisms producing these compounds represent a valuable repository, offering intricate structures that inspire the development of potential therapeutics. The rich diversity of natural products also serves as a foundation for the creation of synthetic analogs, propelling innovation in drug discovery and paving the way for novel treatments. This thesis focuses on two different projects involving natural products synthesis and discovery.Advances in mass spectrometry-based metabolomics, bioinformatics, and genetic sequencing capabilities have reinvigorated the field of natural product discovery. Tambromycin, a tetrapeptide with unique structural features, exemplifies the power of combining metabolite data and genomic information through the innovative approach of Metabologenomics. This integrated methodology enhances the precision and efficiency of identifying novel compounds, showcasing the synergy between cutting-edge analytical techniques and genetic insights in uncovering unique natural products. This thesis presents an improved total synthesis approach for trambromycin, resulting in increased material that has helped improve our understanding of its bioactivity profile. The improved synthesis has also played a crucial role in the design and synthesis of tambromycin analogs, offering valuable information into the structure activity relationships within this molecule.The second focal point of this thesis revolves around the targeted discovery of cysteine derived natural products. In contrast to the untargeted method employed in the discovery of tambromycin, which did not emphasize any specific structural features, the targeted approach in this case involves a focused investigation on genes predicted to incorporate cysteine and on metabolites predicted to give a cysteine neutral loss. This strategy aims to enhance the likelihood that the identified natural products have bioactivity. Compounds containing cysteine can undergo transformations leading to a diverse array of functional groups, often regarded as privileged structures. These structures exhibit favorable drug-like properties, enhancing the chances that the discovered natural products are active. By specifically focusing on compounds derived from cysteine, this targeted approach leverages the inherent versatility of cysteine-derived functional groups, contributing to the discovery of potential new therapeutic agents.
- 일반주제명
- Organic chemistry
- 일반주제명
- Biology
- 일반주제명
- Chemistry
- 일반주제명
- Bioinformatics
- 일반주제명
- Genetics
- 키워드
- Tambromycin
- 키워드
- Natural products
- 키워드
- Cysteine
- 기타저자
- Northwestern University Chemistry
- 기본자료저록
- Dissertations Abstracts International. 85-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■1001 ▼aDa Silva, Israel.▼0(orcid)0000-0003-4260-1501
■24510▼aStudies in Natural Product Discovery and Total Synthesis: Towards (1) Tambromycin and Analogs and (2) Cysteine Containing Natural Products
■260 ▼a[Sl]▼bNorthwestern University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a137 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-11, Section: B.
■500 ▼aAdvisor: Thomson, Regan J.;Kelleher, Neil.
■5021 ▼aThesis (Ph.D.)--Northwestern University, 2024.
■520 ▼aNatural products and their synthetic analogs have historically been a major contributor for the treatment of disease. Organisms producing these compounds represent a valuable repository, offering intricate structures that inspire the development of potential therapeutics. The rich diversity of natural products also serves as a foundation for the creation of synthetic analogs, propelling innovation in drug discovery and paving the way for novel treatments. This thesis focuses on two different projects involving natural products synthesis and discovery.Advances in mass spectrometry-based metabolomics, bioinformatics, and genetic sequencing capabilities have reinvigorated the field of natural product discovery. Tambromycin, a tetrapeptide with unique structural features, exemplifies the power of combining metabolite data and genomic information through the innovative approach of Metabologenomics. This integrated methodology enhances the precision and efficiency of identifying novel compounds, showcasing the synergy between cutting-edge analytical techniques and genetic insights in uncovering unique natural products. This thesis presents an improved total synthesis approach for trambromycin, resulting in increased material that has helped improve our understanding of its bioactivity profile. The improved synthesis has also played a crucial role in the design and synthesis of tambromycin analogs, offering valuable information into the structure activity relationships within this molecule.The second focal point of this thesis revolves around the targeted discovery of cysteine derived natural products. In contrast to the untargeted method employed in the discovery of tambromycin, which did not emphasize any specific structural features, the targeted approach in this case involves a focused investigation on genes predicted to incorporate cysteine and on metabolites predicted to give a cysteine neutral loss. This strategy aims to enhance the likelihood that the identified natural products have bioactivity. Compounds containing cysteine can undergo transformations leading to a diverse array of functional groups, often regarded as privileged structures. These structures exhibit favorable drug-like properties, enhancing the chances that the discovered natural products are active. By specifically focusing on compounds derived from cysteine, this targeted approach leverages the inherent versatility of cysteine-derived functional groups, contributing to the discovery of potential new therapeutic agents.
■590 ▼aSchool code: 0163.
■650 4▼aOrganic chemistry
■650 4▼aBiology
■650 4▼aChemistry
■650 4▼aBioinformatics
■650 4▼aGenetics
■653 ▼aTambromycin
■653 ▼aMass spectrometry
■653 ▼aNatural products
■653 ▼aSynthetic chemistry
■653 ▼aCysteine
■690 ▼a0490
■690 ▼a0306
■690 ▼a0485
■690 ▼a0369
■690 ▼a0715
■71020▼aNorthwestern University▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g85-11B.
■790 ▼a0163
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160886▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
