Progress Toward the Total Synthesis of Pilosanone C
Progress Toward the Total Synthesis of Pilosanone C
Detailed Information
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151945
- ISBN
- 9798383593257
- DDC
- 540
- 서명/저자
- Progress Toward the Total Synthesis of Pilosanone C
- 발행사항
- [Sl] : Indiana University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 268 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
- 주기사항
- Advisor: Williams, David R.
- 학위논문주기
- Thesis (Ph.D.)--Indiana University, 2024.
- 초록/해제
- 요약Clerodane diterpenes are a large family of secondary metabolites found in hundreds of plant species and prokaryotes. Since 1990, many examples of the clerodane family have been isolated and characterized. Representative compounds are known to possess significant biological properties, notably, insect antifeedant, opioid receptor agonist and hallucinogenic. The basic structure of clerodanes are bicyclic diterpenoids which primarily exist as a 6-6 ring system. The pilosanones are a subset of the clerodane family which contain a unique 6-7 bicylo[5.4.0]undecane ring system. Pilosanone C 1 has a characteristic oxabicyclo[3.2.1]octene core with four contiguous stereocenters, one of which is a quaternary carbon. There are no reports of synthesis studies in pursuit of this target. Much progress has been made in our laboratories to synthesize the natural product including a route to attempt a late-stage metal catalyzed stereoselective [4+3] cyclization, an early stage intramolecular oxidopyrylium [5+2] cycloaddition, and a chiral pool strategy beginning with (R)-(−)-Carvone.
- 일반주제명
- Chemistry
- 일반주제명
- Analytical chemistry
- 일반주제명
- Organic chemistry
- 키워드
- Pilosanones
- 기타저자
- Indiana University Chemistry
- 기본자료저록
- Dissertations Abstracts International. 86-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211151945
■006m o d
■007cr#unu||||||||
■020 ▼a9798383593257
■035 ▼a(MiAaPQ)AAI31327645
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a540
■1001 ▼aDesmond, Jacob Anthony.▼0(orcid)0009-0007-9070-371X
■24510▼aProgress Toward the Total Synthesis of Pilosanone C
■260 ▼a[Sl]▼bIndiana University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a268 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-02, Section: B.
■500 ▼aAdvisor: Williams, David R.
■5021 ▼aThesis (Ph.D.)--Indiana University, 2024.
■520 ▼aClerodane diterpenes are a large family of secondary metabolites found in hundreds of plant species and prokaryotes. Since 1990, many examples of the clerodane family have been isolated and characterized. Representative compounds are known to possess significant biological properties, notably, insect antifeedant, opioid receptor agonist and hallucinogenic. The basic structure of clerodanes are bicyclic diterpenoids which primarily exist as a 6-6 ring system. The pilosanones are a subset of the clerodane family which contain a unique 6-7 bicylo[5.4.0]undecane ring system. Pilosanone C 1 has a characteristic oxabicyclo[3.2.1]octene core with four contiguous stereocenters, one of which is a quaternary carbon. There are no reports of synthesis studies in pursuit of this target. Much progress has been made in our laboratories to synthesize the natural product including a route to attempt a late-stage metal catalyzed stereoselective [4+3] cyclization, an early stage intramolecular oxidopyrylium [5+2] cycloaddition, and a chiral pool strategy beginning with (R)-(−)-Carvone.
■590 ▼aSchool code: 0093.
■650 4▼aChemistry
■650 4▼aAnalytical chemistry
■650 4▼aOrganic chemistry
■653 ▼aClerodane diterpenes
■653 ▼aPilosanones
■653 ▼aSecondary metabolites
■653 ▼aQuaternary carbon
■690 ▼a0485
■690 ▼a0486
■690 ▼a0490
■71020▼aIndiana University▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g86-02B.
■790 ▼a0093
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162206▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
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