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Approaches to Valuable Halogenated Products Using Radical-Polar Crossover Catalysis or Halogen Transfer to Arynes
Approaches to Valuable Halogenated Products Using Radical-Polar Crossover Catalysis or Halogen Transfer to Arynes
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152839
- ISBN
- 9798342715676
- DDC
- 547
- 저자명
- Gavin, Joshua T.
- 서명/저자
- Approaches to Valuable Halogenated Products Using Radical-Polar Crossover Catalysis or Halogen Transfer to Arynes
- 발행사항
- [Sl] : University of Minnesota, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 223 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-05, Section: B.
- 주기사항
- Advisor: Roberts, Courtney C.
- 학위논문주기
- Thesis (Ph.D.)--University of Minnesota, 2024.
- 초록/해제
- 요약Molecules with halogen atoms have many applications. In direct applications, halogenated molecules are seen in many marketed pharmaceuticals and continue to represent a growing proportion year-to-year. They also find applications in agrochemicals, polymers, and materials, and the unique properties halogenation imparts to products has been difficult to replicate by other means. Additionally, halogen-containing molecules have indirect applications for many more products because a halogen-free chemical may succeed from a synthetic intermediate containing a halogen atom. Through reactions such as Pd-catalyzed couplings, halogenated materials have become a regular feature in molecular syntheses. Thus, the synthesis of halogen-containing molecules is a vital part toward supporting the growth of the pharmaceuticals, agrochemicals, and materials industries. New methods to access these products in a more efficient manner benefits many industries. This dissertation discusses two distinct strategies to synthesize valuable halogenated products. First, the application of redox-active ligands with transition-metal catalysis is considered especially with early transition metals. The combination of redox-active ligands with relatively redox-innocent early transition metals enabled a method for synthesis of gem-difluorostyrenes. This process occurs via radical-polar crossover, a mechanism new to early-transition metals. Second, synthesis of halogen-containing products was shown by exploiting known reactivity of arynes. This method involves functionalization with amine nucleophiles followed by a rapid halogen-transfer that competes with other undesirable pathways.
- 일반주제명
- Organic chemistry
- 일반주제명
- Inorganic chemistry
- 일반주제명
- Molecular chemistry
- 키워드
- Aryne
- 키워드
- Catalysis
- 키워드
- Halogen
- 기타저자
- University of Minnesota Chemistry
- 기본자료저록
- Dissertations Abstracts International. 86-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798342715676
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a547
■1001 ▼aGavin, Joshua T.
■24510▼aApproaches to Valuable Halogenated Products Using Radical-Polar Crossover Catalysis or Halogen Transfer to Arynes
■260 ▼a[Sl]▼bUniversity of Minnesota▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a223 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-05, Section: B.
■500 ▼aAdvisor: Roberts, Courtney C.
■5021 ▼aThesis (Ph.D.)--University of Minnesota, 2024.
■520 ▼aMolecules with halogen atoms have many applications. In direct applications, halogenated molecules are seen in many marketed pharmaceuticals and continue to represent a growing proportion year-to-year. They also find applications in agrochemicals, polymers, and materials, and the unique properties halogenation imparts to products has been difficult to replicate by other means. Additionally, halogen-containing molecules have indirect applications for many more products because a halogen-free chemical may succeed from a synthetic intermediate containing a halogen atom. Through reactions such as Pd-catalyzed couplings, halogenated materials have become a regular feature in molecular syntheses. Thus, the synthesis of halogen-containing molecules is a vital part toward supporting the growth of the pharmaceuticals, agrochemicals, and materials industries. New methods to access these products in a more efficient manner benefits many industries. This dissertation discusses two distinct strategies to synthesize valuable halogenated products. First, the application of redox-active ligands with transition-metal catalysis is considered especially with early transition metals. The combination of redox-active ligands with relatively redox-innocent early transition metals enabled a method for synthesis of gem-difluorostyrenes. This process occurs via radical-polar crossover, a mechanism new to early-transition metals. Second, synthesis of halogen-containing products was shown by exploiting known reactivity of arynes. This method involves functionalization with amine nucleophiles followed by a rapid halogen-transfer that competes with other undesirable pathways.
■590 ▼aSchool code: 0130.
■650 4▼aOrganic chemistry
■650 4▼aInorganic chemistry
■650 4▼aMolecular chemistry
■653 ▼aAryne
■653 ▼aCatalysis
■653 ▼aEarly transition metals
■653 ▼aHalogen
■690 ▼a0490
■690 ▼a0488
■690 ▼a0431
■71020▼aUniversity of Minnesota▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g86-05B.
■790 ▼a0130
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17164169▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
