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Social Stress, Inflammatory Reactivity, and Depressive Symptoms
Social Stress, Inflammatory Reactivity, and Depressive Symptoms
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211153116
- ISBN
- 9798384462811
- DDC
- 150
- 서명/저자
- Social Stress, Inflammatory Reactivity, and Depressive Symptoms
- 발행사항
- [Sl] : The Ohio State University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 157 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-04, Section: B.
- 주기사항
- Advisor: Kiecolt-Glaser, Janice K.
- 학위논문주기
- Thesis (Ph.D.)--The Ohio State University, 2024.
- 초록/해제
- 요약Background: Approximately one-third of depression cases feature clinically elevated inflammation. The Social Signal Transduction Theory of Depression outlines one pathway to inflammation-driven depressive symptoms. It posits that those who report more frequent social stress and who have heightened inflammatory responses to an acute laboratory social stressor will have the greatest depressive symptom increases over time.Aims: This series of studies tested the Social Signal Transduction Theory of Depression, and whether this pathway is specific to social stress. It also investigated whether omega-3 supplementation impedes this etiological pathway, especially among those who are socially stressed.Methods: To test the Social Signal Transduction Theory of Depression, 76 physically healthy adults and 79 breast cancer survivors completed a laboratory social stressor (a marital conflict or the Trier Social Stress Test, respectively), had their blood drawn to assess inflammatory responsivity, and reported their stress exposure at baseline and their depressive symptoms at baseline and follow-up (one month later or four and eight months later, respectively). To test omega-3's effect on inflammatory responses, 138 middle-aged, sedentary adults were randomized to 2.5 g/day of omega-3, 1.25 g/day of omega-3, or placebo for four months. Before and after supplementation, they completed the Trier Social Stress Test and repeatedly had their blood drawn to assess inflammatory responsivity. The final study features secondary analyses from the same randomized, controlled trial to examine whether omega-3 reduced self-reported depressive symptoms among those who reported more social stress.Results: In the first study, those who reported more frequent social stress, but not other types of stress, and had greater inflammatory responsivity at baseline had heightened depressive symptoms at follow-up. This effect was specific to social stress. In the second study, omega-3 supplementation promoted a more resilient physiological response to acute social stress, including lower inflammatory responsivity. In the final study, omega-3's antidepressant effect was greatest among overweight and obese individuals who reported frequent social tension, hostility, or lack of social recognition, but not other types of stress. These effects were largely replicated when using plasma levels of omega-3, rather than supplementation group.Conclusions: Together, these findings provide strong support for the Social Signal Transduction Theory of Depression, showing the unique potency of social stress and inflammatory signaling in depression etiology. Strategies to reduce stress-induced inflammatory responses, such as omega-3 supplementation, may foster stress resilience and prevent depressive symptom worsening, especially among the socially-stressed.
- 일반주제명
- Psychology
- 일반주제명
- Immunology
- 일반주제명
- Clinical psychology
- 일반주제명
- Mental health
- 일반주제명
- Social psychology
- 키워드
- Inflammation
- 키워드
- Depression
- 키워드
- Social stress
- 키워드
- Marital conflict
- 기타저자
- The Ohio State University Psychology
- 기본자료저록
- Dissertations Abstracts International. 86-04B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211153116
■006m o d
■007cr#unu||||||||
■020 ▼a9798384462811
■035 ▼a(MiAaPQ)AAI31693966
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a150
■1001 ▼aMadison, Annelise A.
■24510▼aSocial Stress, Inflammatory Reactivity, and Depressive Symptoms
■260 ▼a[Sl]▼bThe Ohio State University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a157 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-04, Section: B.
■500 ▼aAdvisor: Kiecolt-Glaser, Janice K.
■5021 ▼aThesis (Ph.D.)--The Ohio State University, 2024.
■520 ▼aBackground: Approximately one-third of depression cases feature clinically elevated inflammation. The Social Signal Transduction Theory of Depression outlines one pathway to inflammation-driven depressive symptoms. It posits that those who report more frequent social stress and who have heightened inflammatory responses to an acute laboratory social stressor will have the greatest depressive symptom increases over time.Aims: This series of studies tested the Social Signal Transduction Theory of Depression, and whether this pathway is specific to social stress. It also investigated whether omega-3 supplementation impedes this etiological pathway, especially among those who are socially stressed.Methods: To test the Social Signal Transduction Theory of Depression, 76 physically healthy adults and 79 breast cancer survivors completed a laboratory social stressor (a marital conflict or the Trier Social Stress Test, respectively), had their blood drawn to assess inflammatory responsivity, and reported their stress exposure at baseline and their depressive symptoms at baseline and follow-up (one month later or four and eight months later, respectively). To test omega-3's effect on inflammatory responses, 138 middle-aged, sedentary adults were randomized to 2.5 g/day of omega-3, 1.25 g/day of omega-3, or placebo for four months. Before and after supplementation, they completed the Trier Social Stress Test and repeatedly had their blood drawn to assess inflammatory responsivity. The final study features secondary analyses from the same randomized, controlled trial to examine whether omega-3 reduced self-reported depressive symptoms among those who reported more social stress.Results: In the first study, those who reported more frequent social stress, but not other types of stress, and had greater inflammatory responsivity at baseline had heightened depressive symptoms at follow-up. This effect was specific to social stress. In the second study, omega-3 supplementation promoted a more resilient physiological response to acute social stress, including lower inflammatory responsivity. In the final study, omega-3's antidepressant effect was greatest among overweight and obese individuals who reported frequent social tension, hostility, or lack of social recognition, but not other types of stress. These effects were largely replicated when using plasma levels of omega-3, rather than supplementation group.Conclusions: Together, these findings provide strong support for the Social Signal Transduction Theory of Depression, showing the unique potency of social stress and inflammatory signaling in depression etiology. Strategies to reduce stress-induced inflammatory responses, such as omega-3 supplementation, may foster stress resilience and prevent depressive symptom worsening, especially among the socially-stressed.
■590 ▼aSchool code: 0168.
■650 4▼aPsychology
■650 4▼aImmunology
■650 4▼aClinical psychology
■650 4▼aMental health
■650 4▼aSocial psychology
■653 ▼aInflammation
■653 ▼aDepression
■653 ▼aSocial stress
■653 ▼aMarital conflict
■653 ▼aSocial Signal Transduction Theory of Depression
■690 ▼a0621
■690 ▼a0622
■690 ▼a0982
■690 ▼a0347
■690 ▼a0451
■71020▼aThe Ohio State University▼bPsychology.
■7730 ▼tDissertations Abstracts International▼g86-04B.
■790 ▼a0168
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17165041▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
