The Interplay Between White Matter, Cytoarchitecture, and Function Over the Development of the Human Visual System
The Interplay Between White Matter, Cytoarchitecture, and Function Over the Development of the Human Visual System
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211153119
- ISBN
- 9798346788706
- DDC
- 306
- 저자명
- Kubota, Emily.
- 서명/저자
- The Interplay Between White Matter, Cytoarchitecture, and Function Over the Development of the Human Visual System
- 발행사항
- [Sl] : Stanford University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 209 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-06, Section: A.
- 주기사항
- Advisor: Grill-Spector, Kalanit.
- 학위논문주기
- Thesis (Ph.D.)--Stanford University, 2024.
- 초록/해제
- 요약Ventral temporal cortex consists of regions that are selectively involved in processing di↵erent categories like faces, places, words, and bodies. These regions emerge in consistent anatomical locations which has led to the predominant theory that innate white matter connections might sca↵old the development of functional regions. In this dissertation, I present a theoretical and methodological framework for identifying the white matter connections of functional regions in visual cortex. In Chapter 2, I review novel approaches for combining functional regions identified with functional magnetic resonance imaging (fMRI) with white matter connections identified using di↵usion magnetic resonance imaging (dMRI) to get a better understanding of the functional relevance of the connections of the brain (Grotheer, Kubota, and Grill-Spector, 2022,Brain Structure and Function). In Chapter 3, I introduce a novel software implementation for identifying functionally-defined white matter connections (Meisler*, Kubota* et al., 2024, Frontiers in Neuroscience). I then apply this theoretical and methodological framework to two empirical studies. In Chapter 4, I test whether white matter connectivity is organized by category or cytoarchitecture in children and adults (Kubota et al., 2023, Cerebral Cortex ). I find that white matter connectivity of ventral temporal cortex is organized by cytoarchitecture in children and both cytoarchitecture and category in adults. These results suggest that regions selective for di↵erent categories have similar white matter connections early in development, and that more specialized connections emerge in adulthood. In Chapter 5, I test whether the relationship between white matter and cytoarchitecture is innate in a sample of infants within the first six months of life and adults (Kubota et al., 2024, bioRxiv). I find that white matter connections of ventral temporal cortex are organized by cytoarchitecture already from infancy and that the connections of functional regions located within the same cytoarchitectonic area develop in parallel, with increasing connections to the frontal lobe and decreasing connections to the occipital lobe and somatosensory cortex. This dissertation provides a theoretical and methodological framework for identifying the white matter connections of functional regions in cortex and demonstrates that white matter connections of ventral temporal cortex are organized by cytoarchitecture in infancy, childhood, and adulthood. In addition, I show that white matter connections have both innate constraints and the capacity to change over development.
- 일반주제명
- Families & family life
- 일반주제명
- Software
- 일반주제명
- Children & youth
- 기타저자
- Stanford University.
- 기본자료저록
- Dissertations Abstracts International. 86-06A.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a306
■1001 ▼aKubota, Emily.
■24510▼aThe Interplay Between White Matter, Cytoarchitecture, and Function Over the Development of the Human Visual System
■260 ▼a[Sl]▼bStanford University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a209 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-06, Section: A.
■500 ▼aAdvisor: Grill-Spector, Kalanit.
■5021 ▼aThesis (Ph.D.)--Stanford University, 2024.
■520 ▼aVentral temporal cortex consists of regions that are selectively involved in processing di↵erent categories like faces, places, words, and bodies. These regions emerge in consistent anatomical locations which has led to the predominant theory that innate white matter connections might sca↵old the development of functional regions. In this dissertation, I present a theoretical and methodological framework for identifying the white matter connections of functional regions in visual cortex. In Chapter 2, I review novel approaches for combining functional regions identified with functional magnetic resonance imaging (fMRI) with white matter connections identified using di↵usion magnetic resonance imaging (dMRI) to get a better understanding of the functional relevance of the connections of the brain (Grotheer, Kubota, and Grill-Spector, 2022,Brain Structure and Function). In Chapter 3, I introduce a novel software implementation for identifying functionally-defined white matter connections (Meisler*, Kubota* et al., 2024, Frontiers in Neuroscience). I then apply this theoretical and methodological framework to two empirical studies. In Chapter 4, I test whether white matter connectivity is organized by category or cytoarchitecture in children and adults (Kubota et al., 2023, Cerebral Cortex ). I find that white matter connectivity of ventral temporal cortex is organized by cytoarchitecture in children and both cytoarchitecture and category in adults. These results suggest that regions selective for di↵erent categories have similar white matter connections early in development, and that more specialized connections emerge in adulthood. In Chapter 5, I test whether the relationship between white matter and cytoarchitecture is innate in a sample of infants within the first six months of life and adults (Kubota et al., 2024, bioRxiv). I find that white matter connections of ventral temporal cortex are organized by cytoarchitecture already from infancy and that the connections of functional regions located within the same cytoarchitectonic area develop in parallel, with increasing connections to the frontal lobe and decreasing connections to the occipital lobe and somatosensory cortex. This dissertation provides a theoretical and methodological framework for identifying the white matter connections of functional regions in cortex and demonstrates that white matter connections of ventral temporal cortex are organized by cytoarchitecture in infancy, childhood, and adulthood. In addition, I show that white matter connections have both innate constraints and the capacity to change over development.
■590 ▼aSchool code: 0212.
■650 4▼aFamilies & family life
■650 4▼aSoftware
■650 4▼aChildren & youth
■650 4▼aIndividual & family studies
■690 ▼a0628
■71020▼aStanford University.
■7730 ▼tDissertations Abstracts International▼g86-06A.
■790 ▼a0212
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17165065▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
