본문

서브메뉴

Advancing Clinical Outcome Prediction Through Innovative Multimodal and Domain-Generalized AI That Accommodates Limited Data
Advancing Clinical Outcome Prediction Through Innovative Multimodal and Domain-Generalized...
Advancing Clinical Outcome Prediction Through Innovative Multimodal and Domain-Generalized AI That Accommodates Limited Data

상세정보

자료유형  
 학위논문 서양
최종처리일시  
20250211152108
ISBN  
9798382741369
DDC  
610
저자명  
Warner, Elisa Villaflores.
서명/저자  
Advancing Clinical Outcome Prediction Through Innovative Multimodal and Domain-Generalized AI That Accommodates Limited Data
발행사항  
[Sl] : University of Michigan, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
210 p
주기사항  
Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
주기사항  
Advisor: Rao, Arvind.
학위논문주기  
Thesis (Ph.D.)--University of Michigan, 2024.
초록/해제  
요약Clinical decision support systems are computer-based systems developed with the goal of assisting health care providers in arduous clinical tasks or improving decision-making. In routine clinical care, medical practices tend to be dynamic and must account for diversity of data. In this thesis, we focus on developing innovative multimodal and multidomain AI models for clinical decision support, with a focus on applications with limited data availability. We start with a survey chapter followed by three case studies of multimodal/multidomain proof-of-concept Clinical Decision Support (CDS) models that accommodate limited data. Our research seeks to address questions regarding constructing machine-learning-based models that mimic real-world mental models and bridge domain gaps in cases of limited data. In the first chapter, we explore a survey of state-of-the-art methods in multimodal machine learning applied to biomedicine, highlighting how these models address five challenges of multimodal machine learning: representation, fusion, translation, alignment and co-learning. Next, we tackle a case study where we develop a low-parameter model to discriminate pseudoprogression and true progression in glioblastoma using a small sample of MRI images. Then, we develop a clinically-informed privileged learning model which leverages both routine clinical data and privileged information (CBCT and protein serum/saliva tests) to detect Temporomandibular Joint Osteoarthritis (TMJ OA). Finally, we present a case of domain generalization to allow a model trained on one Alcon SN60WF lens to predict post-operative refraction in patients implanted with other lenses in cataract surgery, with an attempt to adapt to other populations and "A-constants" as well. We present these three case studies as examples of informed models that accommodate diverse data types, as real-world clinical practice is intrinsically multimodal and multidomain. We hope these models provide inspiration for additional models outside of the provided use cases and assert that methodologies can be combined and adapted as needed.
일반주제명  
Medicine
일반주제명  
Computer science
일반주제명  
Bioinformatics
키워드  
Multimodal machine learning
키워드  
Domain generalization
키워드  
Privileged learning model
키워드  
Clinical Decision Support
기타저자  
University of Michigan Bioinformatics
기본자료저록  
Dissertations Abstracts International. 85-12B.
전자적 위치 및 접속  
로그인 후 원문을 볼 수 있습니다.

MARC

 008250123s2024        us                              c    eng  d
■001000017162884
■00520250211152108
■006m          o    d                
■007cr#unu||||||||
■020    ▼a9798382741369
■035    ▼a(MiAaPQ)AAI31349166
■035    ▼a(MiAaPQ)umichrackham005401
■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a610
■1001  ▼aWarner,  Elisa  Villaflores.
■24510▼aAdvancing  Clinical  Outcome  Prediction  Through  Innovative  Multimodal  and  Domain-Generalized  AI  That  Accommodates  Limited  Data
■260    ▼a[Sl]▼bUniversity  of  Michigan▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a210  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  85-12,  Section:  B.
■500    ▼aAdvisor:  Rao,  Arvind.
■5021  ▼aThesis  (Ph.D.)--University  of  Michigan,  2024.
■520    ▼aClinical  decision  support  systems  are  computer-based  systems  developed  with  the  goal  of  assisting  health  care  providers  in  arduous  clinical  tasks  or  improving  decision-making.  In  routine  clinical  care,  medical  practices  tend  to  be  dynamic  and  must  account  for  diversity  of  data.  In  this  thesis,  we  focus  on  developing  innovative  multimodal  and  multidomain  AI  models  for  clinical  decision  support,  with  a  focus  on  applications  with  limited  data  availability.  We  start  with  a  survey  chapter  followed  by  three  case  studies  of  multimodal/multidomain  proof-of-concept  Clinical  Decision  Support  (CDS)  models  that  accommodate  limited  data.  Our  research  seeks  to  address  questions  regarding  constructing  machine-learning-based  models  that  mimic  real-world  mental  models  and  bridge  domain  gaps  in  cases  of  limited  data.  In  the  first  chapter,  we  explore  a  survey  of  state-of-the-art  methods  in  multimodal  machine  learning  applied  to  biomedicine,  highlighting  how  these  models  address  five  challenges  of  multimodal  machine  learning:  representation,  fusion,  translation,  alignment  and  co-learning.  Next,  we  tackle  a  case  study  where  we  develop  a  low-parameter  model  to  discriminate  pseudoprogression  and  true  progression  in  glioblastoma  using  a  small  sample  of  MRI  images.  Then,  we  develop  a  clinically-informed  privileged  learning  model  which  leverages  both  routine  clinical  data  and  privileged  information  (CBCT  and  protein  serum/saliva  tests)  to  detect  Temporomandibular  Joint  Osteoarthritis  (TMJ  OA).  Finally,  we  present  a  case  of  domain  generalization  to  allow  a  model  trained  on  one  Alcon  SN60WF  lens  to  predict  post-operative  refraction  in  patients  implanted  with  other  lenses  in  cataract  surgery,  with  an  attempt  to  adapt  to  other  populations  and  "A-constants"  as  well.  We  present  these  three  case  studies  as  examples  of  informed  models  that  accommodate  diverse  data  types,  as  real-world  clinical  practice  is  intrinsically  multimodal  and  multidomain.  We  hope  these  models  provide  inspiration  for  additional  models  outside  of  the  provided  use  cases  and  assert  that  methodologies  can  be  combined  and  adapted  as  needed.
■590    ▼aSchool  code:  0127.
■650  4▼aMedicine
■650  4▼aComputer  science
■650  4▼aBioinformatics
■653    ▼aMultimodal  machine  learning
■653    ▼aDomain  generalization
■653    ▼aPrivileged  learning  model
■653    ▼aClinical  Decision  Support
■690    ▼a0715
■690    ▼a0984
■690    ▼a0564
■690    ▼a0800
■71020▼aUniversity  of  Michigan▼bBioinformatics.
■7730  ▼tDissertations  Abstracts  International▼g85-12B.
■790    ▼a0127
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162884▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

미리보기

내보내기

chatGPT토론

Ai 추천 관련 도서


    신착도서 더보기
    최근 3년간 통계입니다.

    소장정보

    • 예약
    • 소재불명신고
    • 나의폴더
    • 우선정리요청
    • 비도서대출신청
    • 야간 도서대출신청
    소장자료
    등록번호 청구기호 소장처 대출가능여부 대출정보
    TF12833 전자도서 대출가능 마이폴더 부재도서신고 비도서대출신청 야간 도서대출신청

    * 대출중인 자료에 한하여 예약이 가능합니다. 예약을 원하시면 예약버튼을 클릭하십시오.

    해당 도서를 다른 이용자가 함께 대출한 도서

    관련 인기도서

    로그인 후 이용 가능합니다.