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Cerebellar and Cortical Acute Manipulations and Permanent Lesions Yield Distinct Effects in Online Corrections of Mouse Licking
Cerebellar and Cortical Acute Manipulations and Permanent Lesions Yield Distinct Effects in Online Corrections of Mouse Licking
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152719
- ISBN
- 9798384053897
- DDC
- 616
- 저자명
- Huang, Xu .
- 서명/저자
- Cerebellar and Cortical Acute Manipulations and Permanent Lesions Yield Distinct Effects in Online Corrections of Mouse Licking
- 발행사항
- [Sl] : Cornell University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 72 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Goldberg, Jesse.
- 학위논문주기
- Thesis (Ph.D.)--Cornell University, 2024.
- 초록/해제
- 요약Accurate execution of goal-directed behaviors requires rapid adjustments to ongoing movements to correct for potential errors. Well-coordinated chewing, swallowing and vocalizing rely on the tongue to make such online corrections based on real-time sensory information. However, the neural circuits necessary for this process are largely unknown. Does the tongue employ the same neural circuits used by other effectors to make online corrections? Does the tongue engage different brain regions for different types of online corrections?The cerebellum has been implicated in both rapid online corrections and lingual control. Here, I used both acute and permanent perturbations of the cerebellum to study its involvement in online corrections of tongue movements. I leveraged the advantages of the head-fixed mouse preparation and high spatiotemporal resolution tongue imaging to study touch- and miss-guided online corrections in two different lick paradigms.In chapter 2, I tested the hypothesis that FN is necessary to touch-guided online corrections in a left/right double-step paradigm. Mice preserved the ability to re-aim subsequent licks based on touch information from previous licks after bilateral FN lesion, which argued against the hypothesis.In chapter 3, I tested the involvements of FN and ALM in miss-guided online corrections with a retraction double-step paradigm. Miss-guided online corrections were impaired with Crus bilaterally photoactivated, but remained intact after bilateral FN lesions. The distinct effects yielded from acute photomanipulation and permanent lesion inspired me to revisit the anterolateral motor cortex (ALM), an area established in previous work to be important to miss-guided corrections based on its photoinactivation-induced impairments and neural activity (Bollu & Ito et al., 2021). Surprisingly, my results showed that CSMs and spout contact remained intact after bilateral ALM lesions. Together, these findings suggest that intact FN or ALM is not necessary for miss-guided corrections. Although my lesion results ruled out FN and ALM for a minimal neural circuit underlying miss-guided CSMs and spout contact, when taken together with findings from acute photomanipulations, they suggest an important facilitative role for these areas.
- 일반주제명
- Neurosciences
- 일반주제명
- Behavioral sciences
- 일반주제명
- Biology
- 일반주제명
- Medical imaging
- 일반주제명
- Behavioral psychology
- 키워드
- Cerebellum
- 키워드
- Lesion
- 키워드
- Tongue imaging
- 기타저자
- Cornell University Neurobiology and Behavior
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211152719
■006m o d
■007cr#unu||||||||
■020 ▼a9798384053897
■035 ▼a(MiAaPQ)AAI31489474
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aHuang, Xu .▼0(orcid)0009-0000-2995-7488
■24510▼aCerebellar and Cortical Acute Manipulations and Permanent Lesions Yield Distinct Effects in Online Corrections of Mouse Licking
■260 ▼a[Sl]▼bCornell University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a72 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Goldberg, Jesse.
■5021 ▼aThesis (Ph.D.)--Cornell University, 2024.
■520 ▼aAccurate execution of goal-directed behaviors requires rapid adjustments to ongoing movements to correct for potential errors. Well-coordinated chewing, swallowing and vocalizing rely on the tongue to make such online corrections based on real-time sensory information. However, the neural circuits necessary for this process are largely unknown. Does the tongue employ the same neural circuits used by other effectors to make online corrections? Does the tongue engage different brain regions for different types of online corrections?The cerebellum has been implicated in both rapid online corrections and lingual control. Here, I used both acute and permanent perturbations of the cerebellum to study its involvement in online corrections of tongue movements. I leveraged the advantages of the head-fixed mouse preparation and high spatiotemporal resolution tongue imaging to study touch- and miss-guided online corrections in two different lick paradigms.In chapter 2, I tested the hypothesis that FN is necessary to touch-guided online corrections in a left/right double-step paradigm. Mice preserved the ability to re-aim subsequent licks based on touch information from previous licks after bilateral FN lesion, which argued against the hypothesis.In chapter 3, I tested the involvements of FN and ALM in miss-guided online corrections with a retraction double-step paradigm. Miss-guided online corrections were impaired with Crus bilaterally photoactivated, but remained intact after bilateral FN lesions. The distinct effects yielded from acute photomanipulation and permanent lesion inspired me to revisit the anterolateral motor cortex (ALM), an area established in previous work to be important to miss-guided corrections based on its photoinactivation-induced impairments and neural activity (Bollu & Ito et al., 2021). Surprisingly, my results showed that CSMs and spout contact remained intact after bilateral ALM lesions. Together, these findings suggest that intact FN or ALM is not necessary for miss-guided corrections. Although my lesion results ruled out FN and ALM for a minimal neural circuit underlying miss-guided CSMs and spout contact, when taken together with findings from acute photomanipulations, they suggest an important facilitative role for these areas.
■590 ▼aSchool code: 0058.
■650 4▼aNeurosciences
■650 4▼aBehavioral sciences
■650 4▼aBiology
■650 4▼aMedical imaging
■650 4▼aBehavioral psychology
■653 ▼aCerebellum
■653 ▼aCorrective submovements
■653 ▼aLesion
■653 ▼aOnline corrections
■653 ▼aPhotomanipulation
■653 ▼aTongue imaging
■690 ▼a0317
■690 ▼a0602
■690 ▼a0306
■690 ▼a0574
■690 ▼a0384
■71020▼aCornell University▼bNeurobiology and Behavior.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0058
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17163522▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
