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Gonadotropin-Inhibitory Hormone and Its Receptor in Spinal Cord: A Novel Pathway for Neuropeptide Action?
Gonadotropin-Inhibitory Hormone and Its Receptor in Spinal Cord: A Novel Pathway for Neuropeptide Action?
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152719
- ISBN
- 9798384455417
- DDC
- 612
- 저자명
- Comito, Devon.
- 서명/저자
- Gonadotropin-Inhibitory Hormone and Its Receptor in Spinal Cord: A Novel Pathway for Neuropeptide Action?
- 발행사항
- [Sl] : University of California, Berkeley, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 60 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Bentley, George E.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Berkeley, 2024.
- 초록/해제
- 요약Gonadotropin-inhibitory hormone (GnIH) is a neuropeptide that typically acts in the hypothalamic-pituitary-gonadal (HPG) axis to inhibit reproductive activity and sociosexual behaviors. GnIH is synthesized in the brain and in the gonads, where it can act via its cognate receptor. However, immunohistological evidence in songbirds also shows GnIH projections towards the brainstem1. I propose that GnIH can act within the spinal cord and possibly on a variety of organs to induce rapid behavioral and physiological changes in response to environmental cues. I hypothesize that the hypothalamus directly innervates the gonads via the spinal cord to rapidly regulate steroid synthesis. I first used immunohistochemistry and PCR to provide a description of GnIH and its receptor in the zebra finch (Taeniopygia guttata) spinal cord. I then investigated potential roles and mechanisms of action of GnIH in the spinal cord of European starlings (Sturnus vulgaris) and zebra finches. I found that seasonal changes in daylength correlated with immunoreactive GnIH and its counterpart, gonadotropin-releasing hormone (GnRH), quantity in wild-caught European starling spinal cord. Food restriction and a sickness challenge caused significant behavioral changes but did not correlate with GnIH-immunoreactive quantity nor measured gene expression levels in zebra finches. These results hint at a novel pathway for neuropeptide action in vertebrates. The mechanisms of action of GnIH in the avian spinal cord are still unclear. However, these three chapters provide the first evidence of reproductive neuropeptides in the avian spinal cord and open exciting new paths for research.
- 일반주제명
- Physiology
- 일반주제명
- Endocrinology
- 일반주제명
- Neurosciences
- 키워드
- Behavior
- 키워드
- Bird
- 키워드
- Reproduction
- 키워드
- Spinal cord
- 기타저자
- University of California, Berkeley Integrative Biology
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211152719
■006m o d
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■020 ▼a9798384455417
■035 ▼a(MiAaPQ)AAI31489519
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a612
■1001 ▼aComito, Devon.
■24510▼aGonadotropin-Inhibitory Hormone and Its Receptor in Spinal Cord: A Novel Pathway for Neuropeptide Action?
■260 ▼a[Sl]▼bUniversity of California, Berkeley▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a60 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Bentley, George E.
■5021 ▼aThesis (Ph.D.)--University of California, Berkeley, 2024.
■520 ▼aGonadotropin-inhibitory hormone (GnIH) is a neuropeptide that typically acts in the hypothalamic-pituitary-gonadal (HPG) axis to inhibit reproductive activity and sociosexual behaviors. GnIH is synthesized in the brain and in the gonads, where it can act via its cognate receptor. However, immunohistological evidence in songbirds also shows GnIH projections towards the brainstem1. I propose that GnIH can act within the spinal cord and possibly on a variety of organs to induce rapid behavioral and physiological changes in response to environmental cues. I hypothesize that the hypothalamus directly innervates the gonads via the spinal cord to rapidly regulate steroid synthesis. I first used immunohistochemistry and PCR to provide a description of GnIH and its receptor in the zebra finch (Taeniopygia guttata) spinal cord. I then investigated potential roles and mechanisms of action of GnIH in the spinal cord of European starlings (Sturnus vulgaris) and zebra finches. I found that seasonal changes in daylength correlated with immunoreactive GnIH and its counterpart, gonadotropin-releasing hormone (GnRH), quantity in wild-caught European starling spinal cord. Food restriction and a sickness challenge caused significant behavioral changes but did not correlate with GnIH-immunoreactive quantity nor measured gene expression levels in zebra finches. These results hint at a novel pathway for neuropeptide action in vertebrates. The mechanisms of action of GnIH in the avian spinal cord are still unclear. However, these three chapters provide the first evidence of reproductive neuropeptides in the avian spinal cord and open exciting new paths for research.
■590 ▼aSchool code: 0028.
■650 4▼aPhysiology
■650 4▼aEndocrinology
■650 4▼aNeurosciences
■653 ▼aBehavior
■653 ▼aBird
■653 ▼aNeuroendocrinology
■653 ▼aReproduction
■653 ▼aSpinal cord
■690 ▼a0719
■690 ▼a0409
■690 ▼a0317
■71020▼aUniversity of California, Berkeley▼bIntegrative Biology.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0028
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17163525▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
