서브메뉴
검색
Genetic, Metabolomic, and Lifestyle Dynamics in Colorectal Cancer and Chronic Disease Prevention
Genetic, Metabolomic, and Lifestyle Dynamics in Colorectal Cancer and Chronic Disease Prevention
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211150934
- ISBN
- 9798381947694
- DDC
- 614.4
- 저자명
- Bever, Alaina M.
- 서명/저자
- Genetic, Metabolomic, and Lifestyle Dynamics in Colorectal Cancer and Chronic Disease Prevention
- 발행사항
- [Sl] : Harvard University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 119 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-09, Section: B.
- 주기사항
- Advisor: Song, Mingyang.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2024.
- 초록/해제
- 요약Noncommunicable chronic disease is a group of conditions that includes type 2 diabetes, cardiovascular disease, and cancer, and accounts for the majority of total deaths in the United States. Many of these diseases are associated with overweight and obese body mass index, however, the pathways linking genetics, modifiable factors, and physiologic characteristics such as inflammation and insulin resistance to chronic disease development are not well understood. A more nuanced understanding of how excess adiposity and related risk factors influence chronic disease is needed to develop improved prevention strategies. We leveraged data from three prospective cohort studies, the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-up Study, to explore these risk factors in relation to chronic disease. In Chapter 1, we evaluated the association of genetically predicted BMI with different colorectal cancer precursor lesions: conventional adenomas and serrated polyps. We found similar associations between measured or genetic BMI and colorectal cancer precursors and observed a stronger association of both measured and genetic BMI with serrated polyps and synchronous serrated polyp and conventional adenoma, compared to conventional adenoma alone.In Chapter 2, we developed metabolomic signatures of inflammation and metabolic disturbance and evaluated the association of the signatures with colorectal cancer. We found that both signatures predicted colorectal cancer risk among men, but not women, and we identified promising individual metabolites linking the states of inflammation and metabolic dysregulation to colorectal cancer development. In Chapter 3, we estimated the proportion and number of cases of chronic disease attributable to poor quality diet and inadequate physical activity in the United States, accounting for the effects of these risk factors that is mediated by changes in body weight. We found that 18 percent of chronic disease in 2018 was attributable to poor quality diet and physical activity, with 13 percent not mediated by effects on change in body weight.
- 일반주제명
- Epidemiology
- 일반주제명
- Oncology
- 일반주제명
- Behavioral psychology
- 키워드
- Chronic disease
- 키워드
- Metabolomics
- 기타저자
- Harvard University Population Health Sciences
- 기본자료저록
- Dissertations Abstracts International. 85-09B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008250123s2024 us c eng d■001000017160210
■00520250211150934
■006m o d
■007cr#unu||||||||
■020 ▼a9798381947694
■035 ▼a(MiAaPQ)AAI30990625
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a614.4
■1001 ▼aBever, Alaina M.▼0(orcid)0000-0003-3004-8497
■24510▼aGenetic, Metabolomic, and Lifestyle Dynamics in Colorectal Cancer and Chronic Disease Prevention
■260 ▼a[Sl]▼bHarvard University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a119 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-09, Section: B.
■500 ▼aAdvisor: Song, Mingyang.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2024.
■520 ▼aNoncommunicable chronic disease is a group of conditions that includes type 2 diabetes, cardiovascular disease, and cancer, and accounts for the majority of total deaths in the United States. Many of these diseases are associated with overweight and obese body mass index, however, the pathways linking genetics, modifiable factors, and physiologic characteristics such as inflammation and insulin resistance to chronic disease development are not well understood. A more nuanced understanding of how excess adiposity and related risk factors influence chronic disease is needed to develop improved prevention strategies. We leveraged data from three prospective cohort studies, the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-up Study, to explore these risk factors in relation to chronic disease. In Chapter 1, we evaluated the association of genetically predicted BMI with different colorectal cancer precursor lesions: conventional adenomas and serrated polyps. We found similar associations between measured or genetic BMI and colorectal cancer precursors and observed a stronger association of both measured and genetic BMI with serrated polyps and synchronous serrated polyp and conventional adenoma, compared to conventional adenoma alone.In Chapter 2, we developed metabolomic signatures of inflammation and metabolic disturbance and evaluated the association of the signatures with colorectal cancer. We found that both signatures predicted colorectal cancer risk among men, but not women, and we identified promising individual metabolites linking the states of inflammation and metabolic dysregulation to colorectal cancer development. In Chapter 3, we estimated the proportion and number of cases of chronic disease attributable to poor quality diet and inadequate physical activity in the United States, accounting for the effects of these risk factors that is mediated by changes in body weight. We found that 18 percent of chronic disease in 2018 was attributable to poor quality diet and physical activity, with 13 percent not mediated by effects on change in body weight.
■590 ▼aSchool code: 0084.
■650 4▼aEpidemiology
■650 4▼aOncology
■650 4▼aBehavioral psychology
■653 ▼aChronic disease
■653 ▼aColorectal cancer
■653 ▼aMendelian randomization
■653 ▼aMetabolomics
■653 ▼aPopulation attributable fraction
■690 ▼a0766
■690 ▼a0992
■690 ▼a0384
■71020▼aHarvard University▼bPopulation Health Sciences.
■7730 ▼tDissertations Abstracts International▼g85-09B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160210▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
