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Atomic-Scale Cryogenic Electron Microscopy Imaging of Synthetic Polymers
Atomic-Scale Cryogenic Electron Microscopy Imaging of Synthetic Polymers
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152735
- ISBN
- 9798384455318
- DDC
- 660
- 서명/저자
- Atomic-Scale Cryogenic Electron Microscopy Imaging of Synthetic Polymers
- 발행사항
- [Sl] : University of California, Berkeley, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 90 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Balsara, Nitash.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Berkeley, 2024.
- 초록/해제
- 요약Materials engineering depends on a thorough understanding of the structure-property relationships in order to rationally design better materials. In polymer science, information about the structure of the material generally comes from scattering techniques, such as wide angle X-ray scattering or neutron scattering. These scattering experiments produce information about the material's structure in reciprocal space, so there can at times be ambiguity in the results when transitioning to real space. Transmission electron microscopy (TEM) is widely used in the materials science community to produce direct, atomic-scale images of hard materials. However, special techniques are needed to image polymeric materials with TEM due to the inherent radiation sensitivity in these soft materials. A series of techniques termed cryo-EM have been developed by the structural biology community to produce atomic-resolution images of proteins. Cryo-EM has only sparingly been applied to synthetic polymers, yet it is a promising tool to advance polymer science.This dissertation focuses on the application of cryo-EM techniques to study the atomic structure of synthetic polymers. The atomic-scale images of the polymers are combined with other material characterization data, molecular dynamics simulations, and TEM image simulations in order to understand the governing interactions that control self-assembly at the atomic level. The direct, atomic-scale imaging of synthetic polymer materials serves to advance material engineering by uncovering the structure-property relationships starting at the atomic scale.Chapters 2, 3, and 4 provide detailed studies in using polypeptoids, which are synthetic polymers with a monomer unit similar to peptides, to uncover the effect of single atom substitutions, ionic interactions, and fixed charges on the self-assembly of these materials. Polypeptoids are a great model system to study self-assembly because their unique submonomer synthesis method grants the ability to precisely vary single atoms within the polymer structure. Chapter 2 starts with using this ability to study the effect of halogen substitutions on the self-assembly and crystal motifs of polypeptoid nanosheets. Chapter 3 investigates the effect of fixed charges and condensed counterions in polypeptoid nanofibers. Chapter 4 details an investigation into the effect of fixed charges and charge density on polypeptoid self-assembly.Chapter 5 applies the same cryo-EM techniques to a conventional diblock copolymer in poly(ethylene oxide)-b-polystyrene (SEO). New synthetic routes were established to create single crystals of SEO with a lithium salt whereby the lithium salt was fully incorporated in the crystal. The single crystals of SEO were imaged with atomic-scale resolution to study how the arrangement of polymer chains changes in response to different amounts of lithium salt. Image simulation based on known crystal structures was used to bring greater understanding to the atomic-scale images.
- 일반주제명
- Chemical engineering
- 일반주제명
- Polymer chemistry
- 일반주제명
- Materials science
- 일반주제명
- Physical chemistry
- 키워드
- Polymers
- 키워드
- Polypeptoids
- 키워드
- Self-assembly
- 기타저자
- University of California, Berkeley Chemical Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211152735
■006m o d
■007cr#unu||||||||
■020 ▼a9798384455318
■035 ▼a(MiAaPQ)AAI31491350
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a660
■1001 ▼aSeidler, Morgan Elizabeth.
■24510▼aAtomic-Scale Cryogenic Electron Microscopy Imaging of Synthetic Polymers
■260 ▼a[Sl]▼bUniversity of California, Berkeley▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a90 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Balsara, Nitash.
■5021 ▼aThesis (Ph.D.)--University of California, Berkeley, 2024.
■520 ▼aMaterials engineering depends on a thorough understanding of the structure-property relationships in order to rationally design better materials. In polymer science, information about the structure of the material generally comes from scattering techniques, such as wide angle X-ray scattering or neutron scattering. These scattering experiments produce information about the material's structure in reciprocal space, so there can at times be ambiguity in the results when transitioning to real space. Transmission electron microscopy (TEM) is widely used in the materials science community to produce direct, atomic-scale images of hard materials. However, special techniques are needed to image polymeric materials with TEM due to the inherent radiation sensitivity in these soft materials. A series of techniques termed cryo-EM have been developed by the structural biology community to produce atomic-resolution images of proteins. Cryo-EM has only sparingly been applied to synthetic polymers, yet it is a promising tool to advance polymer science.This dissertation focuses on the application of cryo-EM techniques to study the atomic structure of synthetic polymers. The atomic-scale images of the polymers are combined with other material characterization data, molecular dynamics simulations, and TEM image simulations in order to understand the governing interactions that control self-assembly at the atomic level. The direct, atomic-scale imaging of synthetic polymer materials serves to advance material engineering by uncovering the structure-property relationships starting at the atomic scale.Chapters 2, 3, and 4 provide detailed studies in using polypeptoids, which are synthetic polymers with a monomer unit similar to peptides, to uncover the effect of single atom substitutions, ionic interactions, and fixed charges on the self-assembly of these materials. Polypeptoids are a great model system to study self-assembly because their unique submonomer synthesis method grants the ability to precisely vary single atoms within the polymer structure. Chapter 2 starts with using this ability to study the effect of halogen substitutions on the self-assembly and crystal motifs of polypeptoid nanosheets. Chapter 3 investigates the effect of fixed charges and condensed counterions in polypeptoid nanofibers. Chapter 4 details an investigation into the effect of fixed charges and charge density on polypeptoid self-assembly.Chapter 5 applies the same cryo-EM techniques to a conventional diblock copolymer in poly(ethylene oxide)-b-polystyrene (SEO). New synthetic routes were established to create single crystals of SEO with a lithium salt whereby the lithium salt was fully incorporated in the crystal. The single crystals of SEO were imaged with atomic-scale resolution to study how the arrangement of polymer chains changes in response to different amounts of lithium salt. Image simulation based on known crystal structures was used to bring greater understanding to the atomic-scale images.
■590 ▼aSchool code: 0028.
■650 4▼aChemical engineering
■650 4▼aPolymer chemistry
■650 4▼aMaterials science
■650 4▼aPhysical chemistry
■653 ▼aElectron microscopy
■653 ▼aPolymer electrolyte
■653 ▼aPolymers
■653 ▼aPolypeptoids
■653 ▼aSelf-assembly
■690 ▼a0542
■690 ▼a0794
■690 ▼a0495
■690 ▼a0494
■71020▼aUniversity of California, Berkeley▼bChemical Engineering.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0028
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17163645▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
