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Precision Examination of Real-world Stress and Behavior Using Deep Digital Phenotyping
Precision Examination of Real-world Stress and Behavior Using Deep Digital Phenotyping
Precision Examination of Real-world Stress and Behavior Using Deep Digital Phenotyping

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자료유형  
 학위논문 서양
최종처리일시  
20250211151413
ISBN  
9798382777641
DDC  
150
저자명  
Vidal Bustamante, Constanza M.
서명/저자  
Precision Examination of Real-world Stress and Behavior Using Deep Digital Phenotyping
발행사항  
[Sl] : Harvard University, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
259 p
주기사항  
Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
주기사항  
Advisor: Buckner, Randy;Somerville, Leah.
학위논문주기  
Thesis (Ph.D.)--Harvard University, 2024.
초록/해제  
요약Life stress has been consistently linked to poor mental health outcomes, but we know comparatively less about the more proximate impacts of life stress on daily affect and behavior. The current dissertation leverages recent advances in digital technology and analytical approaches to examine real-world life stress and its affective and behavioral correlates in a cohort of first-year college students naturally exposed to multifaceted stressors as they transitioned to college life. For a full academic year, participants provided continuous accelerometer data from an actigraphy wristband for the objective estimation of sleep duration and waketime activity. Additionally, participants used their phones to complete daily self-reports of perceived stress sources, affect, behavior, as well as the main events of their day, and completed periodic web-based assessments of global psychopathology symptoms. Similar data was collected in a timely 3-month follow-up study as the same participants underwent a new, unprecedented life transition: the beginning of the COVID-19 pandemic. Following a general review of relevant background literature in Chapter 1, novel insights into real-world life stress drawn from these datasets are offered across three papers presented in Chapters 2 through 4.Chapter 2 (Paper 1) examines fluctuations in stress, affect, and behavior over the course of the first year of college. Negative emotions, sleep patterns, and academic and social activity varied substantially over the course of the year as well as between individuals. Critically, while academics were a common source of stress for all students, a vulnerable subgroup reporting greater frequency of perceived social stress went on to report the highest global clinical symptoms at the end of the year, suggesting dissociable effects of different stress sources on mental health. Two years later, during the COVID-19 pandemic, the first-year subgroup with highest distress again stood out by frequent social stress and elevated clinical symptoms, suggesting that focus on sustained interpersonal stress, relative to academic stress, may be especially helpful to identify students at heightened risk for psychopathology.Chapter 3 (Paper 2) introduces a novel individual-level linear model (iLM) to estimate day-to-day associations between perceived stress levels and actigraphy-derived sleep duration within individuals and unbiased by the group. While stress and sleep duration were inversely related in most participants, the iLM revealed that the temporal direction of these associations is person-specific, identifying a variety of individual phenotypes that may account for the diverse group-level findings reported in prior literature: for some, elevated stress in the day was associated with shorter sleep later that night; for others, shorter sleep was associated with elevated stress the next day; others showed both directions of associations, and some showed no association. Paired with intensive longitudinal data, our individual-level model provides a precision framework for the estimation of stable real-world behavioral and psychological dynamics, and may support the personalized prioritization of intervention targets for health and wellbeing.Chapter 4 (Paper 3) investigates the proximate correlates of academic and social stressful events on daily affect and behavior within individuals. Experiences of stress were characterized from participants' daily voice diaries narrating the main events of the day, using a combination of human labeling and large language models fine-tuned for sentiment analysis and topic modeling. Multilevel models assessing within-person associations found that days with academic stressful events were characterized by shorter sleep duration and decreased physical activity, as well as by reduced social interaction and increased time spent on schoolwork. Meanwhile, days with social stressful events were not systematically associated to changes in behavior, but they stood out by heightened negative affect, above and beyond the effect of academic events. Our results suggest that academic and social dimensions of life stress may have distinct signatures on daily affect and behavior, which in turn may go on to shape individuals' long-term wellbeing.Chapter 5 discusses the main contributions and limitations of this body of work. In all, the current dissertation provides valuable insights into the effects of life stress on real-world emotions, behavior, and overall wellbeing at multiple timescales. Our approach offers a foundation for the characterization of life dynamics at both the individual and the group levels, with potential implications for the development of precision health and wellbeing interventions.
일반주제명  
Psychology
일반주제명  
Mental health
일반주제명  
Clinical psychology
일반주제명  
Behavioral psychology
키워드  
Actigraphy
키워드  
Digital phenotyping
키워드  
Sleep
키워드  
Smartphones
키워드  
Stress
기타저자  
Harvard University Psychology
기본자료저록  
Dissertations Abstracts International. 85-12B.
전자적 위치 및 접속  
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MARC

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■1001  ▼aVidal  Bustamante,  Constanza  M.▼0(orcid)0000-0003-1930-7179
■24510▼aPrecision  Examination  of  Real-world  Stress  and  Behavior  Using  Deep  Digital  Phenotyping
■260    ▼a[Sl]▼bHarvard  University▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a259  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  85-12,  Section:  B.
■500    ▼aAdvisor:  Buckner,  Randy;Somerville,  Leah.
■5021  ▼aThesis  (Ph.D.)--Harvard  University,  2024.
■520    ▼aLife  stress  has  been  consistently  linked  to  poor  mental  health  outcomes,  but  we  know  comparatively  less  about  the  more  proximate  impacts  of  life  stress  on  daily  affect  and  behavior.  The  current  dissertation  leverages  recent  advances  in  digital  technology  and  analytical  approaches  to  examine  real-world  life  stress  and  its  affective  and  behavioral  correlates  in  a  cohort  of  first-year  college  students  naturally  exposed  to  multifaceted  stressors  as  they  transitioned  to  college  life.  For  a  full  academic  year,  participants  provided  continuous  accelerometer  data  from  an  actigraphy  wristband  for  the  objective  estimation  of  sleep  duration  and  waketime  activity.  Additionally,  participants  used  their  phones  to  complete  daily  self-reports  of  perceived  stress  sources,  affect,  behavior,  as  well  as  the  main  events  of  their  day,  and  completed  periodic  web-based  assessments  of  global  psychopathology  symptoms.  Similar  data  was  collected  in  a  timely  3-month  follow-up  study  as  the  same  participants  underwent  a  new,  unprecedented  life  transition:  the  beginning  of  the  COVID-19  pandemic.  Following  a  general  review  of  relevant  background  literature  in  Chapter  1,  novel  insights  into  real-world  life  stress  drawn  from  these  datasets  are  offered  across  three  papers  presented  in  Chapters  2  through  4.Chapter  2  (Paper  1)  examines  fluctuations  in  stress,  affect,  and  behavior  over  the  course  of  the  first  year  of  college.  Negative  emotions,  sleep  patterns,  and  academic  and  social  activity  varied  substantially  over  the  course  of  the  year  as  well  as  between  individuals.  Critically,  while  academics  were  a  common  source  of  stress  for  all  students,  a  vulnerable  subgroup  reporting  greater  frequency  of  perceived  social  stress  went  on  to  report  the  highest  global  clinical  symptoms  at  the  end  of  the  year,  suggesting  dissociable  effects  of  different  stress  sources  on  mental  health.  Two  years  later,  during  the  COVID-19  pandemic,  the  first-year  subgroup  with  highest  distress  again  stood  out  by  frequent  social  stress  and  elevated  clinical  symptoms,  suggesting  that  focus  on  sustained  interpersonal  stress,  relative  to  academic  stress,  may  be  especially  helpful  to  identify  students  at  heightened  risk  for  psychopathology.Chapter  3  (Paper  2)  introduces  a  novel  individual-level  linear  model  (iLM)  to  estimate  day-to-day  associations  between  perceived  stress  levels  and  actigraphy-derived  sleep  duration  within  individuals  and  unbiased  by  the  group.  While  stress  and  sleep  duration  were  inversely  related  in  most  participants,  the  iLM  revealed  that  the  temporal  direction  of  these  associations  is  person-specific,  identifying  a  variety  of  individual  phenotypes  that  may  account  for  the  diverse  group-level  findings  reported  in  prior  literature:  for  some,  elevated  stress  in  the  day  was  associated  with  shorter  sleep  later  that  night;  for  others,  shorter  sleep  was  associated  with  elevated  stress  the  next  day;  others  showed  both  directions  of  associations,  and  some  showed  no  association.  Paired  with  intensive  longitudinal  data,  our  individual-level  model  provides  a  precision  framework  for  the  estimation  of  stable  real-world  behavioral  and  psychological  dynamics,  and  may  support  the  personalized  prioritization  of  intervention  targets  for  health  and  wellbeing.Chapter  4  (Paper  3)  investigates  the  proximate  correlates  of  academic  and  social  stressful  events  on  daily  affect  and  behavior  within  individuals.  Experiences  of  stress  were  characterized  from  participants'  daily  voice  diaries  narrating  the  main  events  of  the  day,  using  a  combination  of  human  labeling  and  large  language  models  fine-tuned  for  sentiment  analysis  and  topic  modeling.  Multilevel  models  assessing  within-person  associations  found  that  days  with  academic  stressful  events  were  characterized  by  shorter  sleep  duration  and  decreased  physical  activity,  as  well  as  by  reduced  social  interaction  and  increased  time  spent  on  schoolwork.  Meanwhile,  days  with  social  stressful  events  were  not  systematically  associated  to  changes  in  behavior,  but  they  stood  out  by  heightened  negative  affect,  above  and  beyond  the  effect  of  academic  events.  Our  results  suggest  that  academic  and  social  dimensions  of  life  stress  may  have  distinct  signatures  on  daily  affect  and  behavior,  which  in  turn  may  go  on  to  shape  individuals'  long-term  wellbeing.Chapter  5  discusses  the  main  contributions  and  limitations  of  this  body  of  work.  In  all,  the  current  dissertation  provides  valuable  insights  into  the  effects  of  life  stress  on  real-world  emotions,  behavior,  and  overall  wellbeing  at  multiple  timescales.  Our  approach  offers  a  foundation  for  the  characterization  of  life  dynamics  at  both  the  individual  and  the  group  levels,  with  potential  implications  for  the  development  of  precision  health  and  wellbeing  interventions.
■590    ▼aSchool  code:  0084.
■650  4▼aPsychology
■650  4▼aMental  health
■650  4▼aClinical  psychology
■650  4▼aBehavioral  psychology
■653    ▼aActigraphy
■653    ▼aDigital  phenotyping
■653    ▼aSleep
■653    ▼aSmartphones
■653    ▼aStress
■690    ▼a0621
■690    ▼a0347
■690    ▼a0622
■690    ▼a0384
■71020▼aHarvard  University▼bPsychology.
■7730  ▼tDissertations  Abstracts  International▼g85-12B.
■790    ▼a0084
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161561▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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