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Joint Longitudinal and Survival Models for Intensive Longitudinal Data from Mobile Health Studies
Joint Longitudinal and Survival Models for Intensive Longitudinal Data from Mobile Health ...
Joint Longitudinal and Survival Models for Intensive Longitudinal Data from Mobile Health Studies

Detailed Information

자료유형  
 학위논문 서양
최종처리일시  
20250211153004
ISBN  
9798384043676
DDC  
574
저자명  
Abbott, Madeline R.
서명/저자  
Joint Longitudinal and Survival Models for Intensive Longitudinal Data from Mobile Health Studies
발행사항  
[Sl] : University of Michigan, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
222 p
주기사항  
Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
주기사항  
Advisor: Dempsey, Walter;Taylor, Jeremy M. G.
학위논문주기  
Thesis (Ph.D.)--University of Michigan, 2024.
초록/해제  
요약Mobile health (mHealth) technology enables the collection of intensive longitudinal data (ILD) and, as a result, serves as a rich source of information on both the short-term and long-term dynamics of multiple outcomes measured over time. When combined with time-to-event outcomes, ILD can provide insight into factors that elevate the risk of an event. Motivated by mHealth studies of smoking cessation in which participants report both longitudinal data on the intensity of many emotions multiple times per day and event-time information on cigarette use, this dissertation presents methods for jointly modeling multivariate ILD and time-to-event outcomes. In the first project, we develop a dynamic factor model that summarizes ILD as a smaller number of time-varying latent factors. The evolution of these latent factors is modeled using a multivariate continuous-time Ornstein-Uhlenbeck stochastic process. We propose a block coordinate descent algorithm for maximum likelihood estimation and apply our method to mHealth data to summarize the dynamics of 18 emotions as two latent factors. These latent factors are interpreted by behavioral scientists as the psychological constructs of positive and negative affect. In the second project, we extend this dynamic factor model to consider an event outcome. Specifically, we use the latent factors as time-varying predictors of a cumulative event outcome (e.g., the total number of cigarettes smoked across repeated intervals of time), which we model using Poisson regression. We take a two-stage approach to estimation; we use weights--based on importance sampling--to account for potential bias that could result from the two-stage approach. In the third project, we extend this dynamic factor model to model the longitudinal process jointly with a traditional survival outcome (e.g., the time of first cigarette use after attempted quit). In this joint longitudinal-survival model, the hazard of a time-to-event outcome is a function of the low-dimensional latent process. Joint estimation of this model is challenging due to the combination of ILD and the presence of a stochastic process as a time-varying covariate in our hazard model. We fit our joint model with a Bayesian approach and use it to analyze data from another mHealth study of smoking cessation. We summarize the longitudinal self-reported intensity of nine emotions as the psychological states of positive and negative affect; these time-varying latent states capture the risk of the first smoking lapse after attempted quit. In the fourth project, we present a model-based approach for estimating the effect of repeatedly delivered treatments in a micro-randomized trial (MRT) via an extension of our joint model. We discuss different ways that these repeated treatment effects can be incorporated into the joint model; these different model specifications correspond to different mechanisms by which treatment is assumed to impact the longitudinal and event processes. Taking a Bayesian approach to inference, we model the association between repeated app-based notifications, longitudinally-measured emotions, and recurrent events of substance use in an mHealth MRT.
일반주제명  
Biostatistics
일반주제명  
Statistics
일반주제명  
Bioinformatics
키워드  
Joint model
키워드  
Intensive longitudinal data
키워드  
Stochastic process
키워드  
Survival analysis
키워드  
Recurrent events
키워드  
Mobile health
기타저자  
University of Michigan Biostatistics
기본자료저록  
Dissertations Abstracts International. 86-03B.
전자적 위치 및 접속  
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MARC

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■0820  ▼a574
■1001  ▼aAbbott,  Madeline  R.
■24510▼aJoint  Longitudinal  and  Survival  Models  for  Intensive  Longitudinal  Data  from  Mobile  Health  Studies
■260    ▼a[Sl]▼bUniversity  of  Michigan▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a222  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  86-03,  Section:  B.
■500    ▼aAdvisor:  Dempsey,  Walter;Taylor,  Jeremy  M.  G.
■5021  ▼aThesis  (Ph.D.)--University  of  Michigan,  2024.
■520    ▼aMobile  health  (mHealth)  technology  enables  the  collection  of  intensive  longitudinal  data  (ILD)  and,  as  a  result,  serves  as  a  rich  source  of  information  on  both  the  short-term  and  long-term  dynamics  of  multiple  outcomes  measured  over  time.  When  combined  with  time-to-event  outcomes,  ILD  can  provide  insight  into  factors  that  elevate  the  risk  of  an  event.  Motivated  by  mHealth  studies  of  smoking  cessation  in  which  participants  report  both  longitudinal  data  on  the  intensity  of  many  emotions  multiple  times  per  day  and  event-time  information  on  cigarette  use,  this  dissertation  presents  methods  for  jointly  modeling  multivariate  ILD  and  time-to-event  outcomes.  In  the  first  project,  we  develop  a  dynamic  factor  model  that  summarizes  ILD  as  a  smaller  number  of  time-varying  latent  factors.  The  evolution  of  these  latent  factors  is  modeled  using  a  multivariate  continuous-time  Ornstein-Uhlenbeck  stochastic  process.  We  propose  a  block  coordinate  descent  algorithm  for  maximum  likelihood  estimation  and  apply  our  method  to  mHealth  data  to  summarize  the  dynamics  of  18  emotions  as  two  latent  factors.  These  latent  factors  are  interpreted  by  behavioral  scientists  as  the  psychological  constructs  of  positive  and  negative  affect.  In  the  second  project,  we  extend  this  dynamic  factor  model  to  consider  an  event  outcome.  Specifically,  we  use  the  latent  factors  as  time-varying  predictors  of  a  cumulative  event  outcome  (e.g.,  the  total  number  of  cigarettes  smoked  across  repeated  intervals  of  time),  which  we  model  using  Poisson  regression.  We  take  a  two-stage  approach  to  estimation;  we  use  weights--based  on  importance  sampling--to  account  for  potential  bias  that  could  result  from  the  two-stage  approach.  In  the  third  project,  we  extend  this  dynamic  factor  model  to  model  the  longitudinal  process  jointly  with  a  traditional  survival  outcome  (e.g.,  the  time  of  first  cigarette  use  after  attempted  quit).  In  this  joint  longitudinal-survival  model,  the  hazard  of  a  time-to-event  outcome  is  a  function  of  the  low-dimensional  latent  process.  Joint  estimation  of  this  model  is  challenging  due  to  the  combination  of  ILD  and  the  presence  of  a  stochastic  process  as  a  time-varying  covariate  in  our  hazard  model.  We  fit  our  joint  model  with  a  Bayesian  approach  and  use  it  to  analyze  data  from  another  mHealth  study  of  smoking  cessation.  We  summarize  the  longitudinal  self-reported  intensity  of  nine  emotions  as  the  psychological  states  of  positive  and  negative  affect;  these  time-varying  latent  states  capture  the  risk  of  the  first  smoking  lapse  after  attempted  quit.  In  the  fourth  project,  we  present  a  model-based  approach  for  estimating  the  effect  of  repeatedly  delivered  treatments  in  a  micro-randomized  trial  (MRT)  via  an  extension  of  our  joint  model.  We  discuss  different  ways  that  these  repeated  treatment  effects  can  be  incorporated  into  the  joint  model;  these  different  model  specifications  correspond  to  different  mechanisms  by  which  treatment  is  assumed  to  impact  the  longitudinal  and  event  processes.  Taking  a  Bayesian  approach  to  inference,  we  model  the  association  between  repeated  app-based  notifications,  longitudinally-measured  emotions,  and  recurrent  events  of  substance  use  in  an  mHealth  MRT.
■590    ▼aSchool  code:  0127.
■650  4▼aBiostatistics
■650  4▼aStatistics
■650  4▼aBioinformatics
■653    ▼aJoint  model
■653    ▼aIntensive  longitudinal  data
■653    ▼aStochastic  process
■653    ▼aSurvival  analysis
■653    ▼aRecurrent  events
■653    ▼aMobile  health
■690    ▼a0308
■690    ▼a0715
■690    ▼a0463
■71020▼aUniversity  of  Michigan▼bBiostatistics.
■7730  ▼tDissertations  Abstracts  International▼g86-03B.
■790    ▼a0127
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17164456▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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