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Genetic Regulation of the Acoustic Startle Threshold
Genetic Regulation of the Acoustic Startle Threshold
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151119
- ISBN
- 9798382834894
- DDC
- 616
- 서명/저자
- Genetic Regulation of the Acoustic Startle Threshold
- 발행사항
- [Sl] : University of Pennsylvania, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 107 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Advisor: Granato, Michael.
- 학위논문주기
- Thesis (Ph.D.)--University of Pennsylvania, 2024.
- 초록/해제
- 요약Animals have a challenging task while navigating their environment: they must continuously ignore irrelevant information while responding to important environmental cues. To achieve this task, animals must establish mechanisms to regulate their behavior in response to their environments. An approach animals can use is to use characteristics of a stimulus, such as the intensity, to determine if a behavioral response is required. The acoustic startle response is a highly conserved defensive behavior during which animals respond to sudden sounds if the sound intensity surpasses a threshold. Regulation of this threshold has two components: establishment of an innate baseline threshold during development and short-term modifications to the threshold based on acute changes in the environment. Dysregulation of the acoustic startle threshold is associated with several human neurodevelopmental and neuropsychiatric disorders. Despite its importance, the genetic mechanisms that underlie establishment of the startle threshold, and how these mechanisms overlap or diverge between establishment and acute regulation are poorly understood. Using a mutant zebrafish line (escapist), I identified a single base pair mutation that is tightly linked to an abnormally lowered baseline acoustic startle threshold. Using the mutation as a genetic tool to identify escapist mutants, I identify that escapist larvae exhibit changes in baseline responses to acoustic and visual stimuli. In contrast, further characterization of short-term regulation of acoustic and visual behavior thresholds identifies that acute regulation remains intact in escapist larvae compared to wildtype siblings. My work highlights the existence of nonoverlapping regulators of baseline and acute behavioral thresholds and provides an entry point to study the genetic and cellular mechanisms underlying the development of innate behavioral thresholds.
- 일반주제명
- Neurosciences
- 일반주제명
- Biology
- 일반주제명
- Genetics
- 일반주제명
- Cellular biology
- 일반주제명
- Acoustics
- 키워드
- Hypersensitivity
- 키워드
- Zebrafish
- 키워드
- Escapist
- 기타저자
- University of Pennsylvania Neuroscience
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211151119
■006m o d
■007cr#unu||||||||
■020 ▼a9798382834894
■035 ▼a(MiAaPQ)AAI31146033
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aOrtiz, Elelbin A.
■24510▼aGenetic Regulation of the Acoustic Startle Threshold
■260 ▼a[Sl]▼bUniversity of Pennsylvania▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a107 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: Granato, Michael.
■5021 ▼aThesis (Ph.D.)--University of Pennsylvania, 2024.
■520 ▼aAnimals have a challenging task while navigating their environment: they must continuously ignore irrelevant information while responding to important environmental cues. To achieve this task, animals must establish mechanisms to regulate their behavior in response to their environments. An approach animals can use is to use characteristics of a stimulus, such as the intensity, to determine if a behavioral response is required. The acoustic startle response is a highly conserved defensive behavior during which animals respond to sudden sounds if the sound intensity surpasses a threshold. Regulation of this threshold has two components: establishment of an innate baseline threshold during development and short-term modifications to the threshold based on acute changes in the environment. Dysregulation of the acoustic startle threshold is associated with several human neurodevelopmental and neuropsychiatric disorders. Despite its importance, the genetic mechanisms that underlie establishment of the startle threshold, and how these mechanisms overlap or diverge between establishment and acute regulation are poorly understood. Using a mutant zebrafish line (escapist), I identified a single base pair mutation that is tightly linked to an abnormally lowered baseline acoustic startle threshold. Using the mutation as a genetic tool to identify escapist mutants, I identify that escapist larvae exhibit changes in baseline responses to acoustic and visual stimuli. In contrast, further characterization of short-term regulation of acoustic and visual behavior thresholds identifies that acute regulation remains intact in escapist larvae compared to wildtype siblings. My work highlights the existence of nonoverlapping regulators of baseline and acute behavioral thresholds and provides an entry point to study the genetic and cellular mechanisms underlying the development of innate behavioral thresholds.
■590 ▼aSchool code: 0175.
■650 4▼aNeurosciences
■650 4▼aBiology
■650 4▼aGenetics
■650 4▼aCellular biology
■650 4▼aAcoustics
■653 ▼aAcoustic sensitivity
■653 ▼aBehavioral thresholds
■653 ▼aHypersensitivity
■653 ▼aZebrafish
■653 ▼aEscapist
■690 ▼a0317
■690 ▼a0306
■690 ▼a0369
■690 ▼a0379
■690 ▼a0986
■71020▼aUniversity of Pennsylvania▼bNeuroscience.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0175
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160804▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
