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Decoding the Cis-Regulatory Principles of Signaling-Responsive Neural Crest Enhancers
Decoding the Cis-Regulatory Principles of Signaling-Responsive Neural Crest Enhancers
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211150919
- ISBN
- 9798382840284
- DDC
- 575
- 서명/저자
- Decoding the Cis-Regulatory Principles of Signaling-Responsive Neural Crest Enhancers
- 발행사항
- [Sl] : Cornell University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 127 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Advisor: Liu, Jun.
- 학위논문주기
- Thesis (Ph.D.)--Cornell University, 2024.
- 초록/해제
- 요약The establishment and maintenance of discrete domains of gene expression are critical for early embryonic development. In vertebrates, embryonic patterning is mediated by the combinatorial action of signaling systems and transcription factors. Cooperation between inductive signals is essential for the establishment of the progenitor cell populations that will give rise to distinct tissues and organs. For example, Wnts and BMPs are both required for the formation of the neural crest, a migratory, multipotent cell population that gives rise to important structures like the craniofacial skeleton and the peripheral nervous system. These signals converge at the neural plate border, the embryonic region where neural crest cells will form, to activate the genes that endow these cells with their unique properties. Neural crest formation is controlled by a gene regulatory network (GRN) composed of dozens of genes expressed in a specific spatial domain within the neural plate border. However, the cis-regulatory principles that allow for the emergence of these discrete patterns of gene expression remain poorly understood. To address this, I examined the regulation of GRN components in avian embryos to identify and dissect genomic elements that are regulated by signaling systems. I focused on signaling-responsive enhancers that control the expression of MSX1 and ZFHX4, which are genes important for the formation of the neural plate border and the neural crest, respectively. I employed these genes and their respective regulatory elements as a model to elucidate the cis-regulatory principles that allow enhancers to interpret multiple signaling inputs and produce specific patterns of gene expression.
- 일반주제명
- Genetics
- 일반주제명
- Developmental biology
- 일반주제명
- Neurosciences
- 키워드
- Neural crest
- 기타저자
- Cornell University Genetics Genomics and Development
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798382840284
■035 ▼a(MiAaPQ)AAI30819190
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a575
■1001 ▼aWilson, Kayla Marie.▼0(orcid)0000-0002-4551-0296
■24510▼aDecoding the Cis-Regulatory Principles of Signaling-Responsive Neural Crest Enhancers
■260 ▼a[Sl]▼bCornell University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a127 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: Liu, Jun.
■5021 ▼aThesis (Ph.D.)--Cornell University, 2024.
■520 ▼aThe establishment and maintenance of discrete domains of gene expression are critical for early embryonic development. In vertebrates, embryonic patterning is mediated by the combinatorial action of signaling systems and transcription factors. Cooperation between inductive signals is essential for the establishment of the progenitor cell populations that will give rise to distinct tissues and organs. For example, Wnts and BMPs are both required for the formation of the neural crest, a migratory, multipotent cell population that gives rise to important structures like the craniofacial skeleton and the peripheral nervous system. These signals converge at the neural plate border, the embryonic region where neural crest cells will form, to activate the genes that endow these cells with their unique properties. Neural crest formation is controlled by a gene regulatory network (GRN) composed of dozens of genes expressed in a specific spatial domain within the neural plate border. However, the cis-regulatory principles that allow for the emergence of these discrete patterns of gene expression remain poorly understood. To address this, I examined the regulation of GRN components in avian embryos to identify and dissect genomic elements that are regulated by signaling systems. I focused on signaling-responsive enhancers that control the expression of MSX1 and ZFHX4, which are genes important for the formation of the neural plate border and the neural crest, respectively. I employed these genes and their respective regulatory elements as a model to elucidate the cis-regulatory principles that allow enhancers to interpret multiple signaling inputs and produce specific patterns of gene expression.
■590 ▼aSchool code: 0058.
■650 4▼aGenetics
■650 4▼aDevelopmental biology
■650 4▼aNeurosciences
■653 ▼aNeural crest
■653 ▼aGene regulatory network
■690 ▼a0369
■690 ▼a0758
■690 ▼a0317
■71020▼aCornell University▼bGenetics, Genomics and Development.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0058
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160149▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
