Development of Hyperpolarized Xenon-129 Imaging Approaches for Assessing Lung Transplantation
Development of Hyperpolarized Xenon-129 Imaging Approaches for Assessing Lung Transplantation
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211150930
- ISBN
- 9798382834603
- DDC
- 610
- 서명/저자
- Development of Hyperpolarized Xenon-129 Imaging Approaches for Assessing Lung Transplantation
- 발행사항
- [Sl] : University of Pennsylvania, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 191 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Advisor: Rizi, Rahim R.
- 학위논문주기
- Thesis (Ph.D.)--University of Pennsylvania, 2024.
- 초록/해제
- 요약Despite noticeably improved early survival rates among lung transplant recipients, those of chronic lung allograft dysfunction (CLAD) and late mortality remain high. CLAD, in particular, is the leading cause of death after the first year post-lung transplantation and the primary limitation to long-term survival. Unfortunately, there is currently no proven therapy for successful CLAD management once diagnosed, though early diagnosis can potentially enable the refinement of treatment strategies to reverse or prevent risk factors before irreversible damage occurs. CLAD remains clinically difficult to diagnose, as spirometry, the current gold standard diagnostic, has low sensitivity for detecting early pathologic changes in small airways and is dependent on patient effort. There is therefore a need for a diagnostic tool capable of detecting CLAD-related lung deterioration in a safe and timely manner in order to improve patient management. Hyperpolarized xenon-129 (HXe) MRI has already been proven sensitive to a variety of lung pathologies that affect lung ventilation and xenon gas exchange, taking advantage of the chemical shifts xenon exhibits moving from the airways (gas-phase) into the parenchyma (dissolved-phase). Directly imaging dissolved-phase (DP) HXe remains challenging, however, due to poor signal and spatial resolution as a consequence of the relatively low concentration of xenon that dissolves into the lung parenchyma. Alternatively, gas exchange can be imaged indirectly at higher signal with Xenon-polarization Transfer Contrast (XTC) MRI by observing the loss of gas-phase (GP) signal after saturating the DP resonance. Traditionally, XTC imaging has involved saturating both DP resonances simultaneously within one or two long breath-holds. In this work, we further developed the XTC technique for selectively saturating either the tissue membrane or red blood cell (RBC) resonance, enabling more specific quantification of gas exchange, and subsequently expanded XTC imaging to incorporate a multi-breath protocol more closely resembling natural breathing- decreasing the burden on the subjects by eliminating long breath-holds. These developments provide more comprehensive lung function measurements than previously achievable with this technique and were assessed longitudinally in lung transplant recipients. Comparisons with spirometry allowed us to identify potential HXe imaging markers reflecting the pathological changes associated with transplant recovery and decline, which may indicate early inflammatory or fibrotic changes characteristic of CLAD.
- 일반주제명
- Bioengineering
- 일반주제명
- Medical imaging
- 일반주제명
- Health sciences
- 일반주제명
- Pathology
- 키워드
- Lung imaging
- 키워드
- MRI
- 기타저자
- University of Pennsylvania Bioengineering
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■1001 ▼aAmzajerdian, Faraz.
■24510▼aDevelopment of Hyperpolarized Xenon-129 Imaging Approaches for Assessing Lung Transplantation
■260 ▼a[Sl]▼bUniversity of Pennsylvania▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a191 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: Rizi, Rahim R.
■5021 ▼aThesis (Ph.D.)--University of Pennsylvania, 2024.
■520 ▼aDespite noticeably improved early survival rates among lung transplant recipients, those of chronic lung allograft dysfunction (CLAD) and late mortality remain high. CLAD, in particular, is the leading cause of death after the first year post-lung transplantation and the primary limitation to long-term survival. Unfortunately, there is currently no proven therapy for successful CLAD management once diagnosed, though early diagnosis can potentially enable the refinement of treatment strategies to reverse or prevent risk factors before irreversible damage occurs. CLAD remains clinically difficult to diagnose, as spirometry, the current gold standard diagnostic, has low sensitivity for detecting early pathologic changes in small airways and is dependent on patient effort. There is therefore a need for a diagnostic tool capable of detecting CLAD-related lung deterioration in a safe and timely manner in order to improve patient management. Hyperpolarized xenon-129 (HXe) MRI has already been proven sensitive to a variety of lung pathologies that affect lung ventilation and xenon gas exchange, taking advantage of the chemical shifts xenon exhibits moving from the airways (gas-phase) into the parenchyma (dissolved-phase). Directly imaging dissolved-phase (DP) HXe remains challenging, however, due to poor signal and spatial resolution as a consequence of the relatively low concentration of xenon that dissolves into the lung parenchyma. Alternatively, gas exchange can be imaged indirectly at higher signal with Xenon-polarization Transfer Contrast (XTC) MRI by observing the loss of gas-phase (GP) signal after saturating the DP resonance. Traditionally, XTC imaging has involved saturating both DP resonances simultaneously within one or two long breath-holds. In this work, we further developed the XTC technique for selectively saturating either the tissue membrane or red blood cell (RBC) resonance, enabling more specific quantification of gas exchange, and subsequently expanded XTC imaging to incorporate a multi-breath protocol more closely resembling natural breathing- decreasing the burden on the subjects by eliminating long breath-holds. These developments provide more comprehensive lung function measurements than previously achievable with this technique and were assessed longitudinally in lung transplant recipients. Comparisons with spirometry allowed us to identify potential HXe imaging markers reflecting the pathological changes associated with transplant recovery and decline, which may indicate early inflammatory or fibrotic changes characteristic of CLAD.
■590 ▼aSchool code: 0175.
■650 4▼aBioengineering
■650 4▼aMedical imaging
■650 4▼aHealth sciences
■650 4▼aPathology
■653 ▼aHyperpolarization
■653 ▼aHyperpolarized xenon-129
■653 ▼aLung imaging
■653 ▼aLung transplantation
■653 ▼aMRI
■690 ▼a0202
■690 ▼a0574
■690 ▼a0566
■690 ▼a0571
■71020▼aUniversity of Pennsylvania▼bBioengineering.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0175
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160191▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
