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Diffusion Tensor and Kurtosis Magnetic Resonance Imaging in Skeletal Muscle
Diffusion Tensor and Kurtosis Magnetic Resonance Imaging in Skeletal Muscle
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152138
- ISBN
- 9798383607138
- DDC
- 616
- 저자명
- Mathew, Ethan.
- 서명/저자
- Diffusion Tensor and Kurtosis Magnetic Resonance Imaging in Skeletal Muscle
- 발행사항
- [Sl] : Arizona State University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 136 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
- 주기사항
- Advisor: Quarles, Chad;Kodibagkar, Vikram.
- 학위논문주기
- Thesis (Ph.D.)--Arizona State University, 2024.
- 초록/해제
- 요약Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness, loss of voluntary motor control, and respiratory problems. Present clinical metrics of ALS remain subjective, suffer from high variability, or require invasive biopsies. Magnetic resonance imaging (MRI) offers the ability to provide quantitative imaging biomarkers and a non-invasive way to monitor and assess ALS progression and structural changes. Diffusion MRI in particular has potential for this purpose due to its sensitivity to microstructural properties. This thesis seeks to evaluate the usefulness of diffusion MRI in skeletal muscle for imaging of ALS patients.This works starts by applying a diffusion tensor imaging (DTI) sequence in the leg of a rat model of ALS. Four ages of rats (corresponding to stages of disease progression) were imaged to assess the ability of diffusion MRI to monitor structural changes secondary to ALS. Results were compared to histological analysis to provide insight into which morphometric features drove the sensitivity of diffusion metrics to ALS. The subsequent studies revolve around testing in healthy controls the repeatability of MR sequences which will eventually be implemented in ALS patients as part of an R61 study. First, the repeatability of a diffusion kurtosis tensor acquisition and the resulting diffusion parameters in the lower legs was validated. Then, since bulbar symptoms are common in ALS, the repeatability of a full bulbar imaging protocol including T1 mapping, T2 mapping, T2* mapping, dynamic T2* mapping, and diffusion kurtosis imaging was analyzed.
- 일반주제명
- Medical imaging
- 일반주제명
- Biomedical engineering
- 일반주제명
- Neurosciences
- 키워드
- Diffusion MRI
- 기타저자
- Arizona State University Biomedical Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211152138
■006m o d
■007cr#unu||||||||
■020 ▼a9798383607138
■035 ▼a(MiAaPQ)AAI31484521
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aMathew, Ethan.
■24510▼aDiffusion Tensor and Kurtosis Magnetic Resonance Imaging in Skeletal Muscle
■260 ▼a[Sl]▼bArizona State University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a136 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-02, Section: B.
■500 ▼aAdvisor: Quarles, Chad;Kodibagkar, Vikram.
■5021 ▼aThesis (Ph.D.)--Arizona State University, 2024.
■520 ▼aAmyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness, loss of voluntary motor control, and respiratory problems. Present clinical metrics of ALS remain subjective, suffer from high variability, or require invasive biopsies. Magnetic resonance imaging (MRI) offers the ability to provide quantitative imaging biomarkers and a non-invasive way to monitor and assess ALS progression and structural changes. Diffusion MRI in particular has potential for this purpose due to its sensitivity to microstructural properties. This thesis seeks to evaluate the usefulness of diffusion MRI in skeletal muscle for imaging of ALS patients.This works starts by applying a diffusion tensor imaging (DTI) sequence in the leg of a rat model of ALS. Four ages of rats (corresponding to stages of disease progression) were imaged to assess the ability of diffusion MRI to monitor structural changes secondary to ALS. Results were compared to histological analysis to provide insight into which morphometric features drove the sensitivity of diffusion metrics to ALS. The subsequent studies revolve around testing in healthy controls the repeatability of MR sequences which will eventually be implemented in ALS patients as part of an R61 study. First, the repeatability of a diffusion kurtosis tensor acquisition and the resulting diffusion parameters in the lower legs was validated. Then, since bulbar symptoms are common in ALS, the repeatability of a full bulbar imaging protocol including T1 mapping, T2 mapping, T2* mapping, dynamic T2* mapping, and diffusion kurtosis imaging was analyzed.
■590 ▼aSchool code: 0010.
■650 4▼aMedical imaging
■650 4▼aBiomedical engineering
■650 4▼aNeurosciences
■653 ▼aAmyotrophic Lateral Sclerosis
■653 ▼aDiffusion MRI
■653 ▼aMagnetic resonance imaging
■653 ▼aMusculoskeletal imaging
■653 ▼aNeurodegenerative disease
■690 ▼a0574
■690 ▼a0541
■690 ▼a0317
■71020▼aArizona State University▼bBiomedical Engineering.
■7730 ▼tDissertations Abstracts International▼g86-02B.
■790 ▼a0010
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17163133▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
