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Heterogeneities in Alzheimer's Disease and Related Dementias: Elucidating the Genetic and Transcriptomic Underpinnings
Heterogeneities in Alzheimer's Disease and Related Dementias: Elucidating the Genetic and Transcriptomic Underpinnings
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211150941
- ISBN
- 9798381971644
- DDC
- 575
- 서명/저자
- Heterogeneities in Alzheimers Disease and Related Dementias: Elucidating the Genetic and Transcriptomic Underpinnings
- 발행사항
- [Sl] : University of California, San Francisco, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 230 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-09, Section: B.
- 주기사항
- Advisor: Yokoyama, Jennifer.
- 학위논문주기
- Thesis (Ph.D.)--University of California, San Francisco, 2024.
- 초록/해제
- 요약Despite the tremendous burden of Alzheimer's disease and related dementias (ADRD on patients, their families, and the public health system, there are still no effective treatments for the disease. Seeking a better understanding of important disease-subgroup-specific associations in a highly heterogeneous patient population, like those diagnosed with ADRD, can help facilitate the development of new therapeutics by enhancing clinical trial design. This thesis focuses on elucidating the genetic and transcriptomic underpinnings of the heterogeneities in ADRD and where these subgroups mechanistically converge.Chapter 1 focuses on features driving sex differences in AD progression to help reveal what protects some individuals and what makes others more vulnerable, ultimately informing the development of personalized therapeutics that benefit both sexes.Chapter 2 presents a meta-analysis of Alzheimer's disease genetics across multiple ancestries and highlights the current lack of diversity in neurodegenerative disease genetic research, suggesting a need for more inclusive studies.Chapter 3 links peripheral immune changes to familial tauopathy and early-onset Alzheimer's, showing altered monocytes in tauopathies and increased interferon-responsive T cells in EOAD. This chapter highlights the importance of the immune system in ADRD.
- 일반주제명
- Genetics
- 일반주제명
- Neurosciences
- 일반주제명
- Pharmacology
- 일반주제명
- Molecular biology
- 일반주제명
- Immunology
- 키워드
- Dementias
- 키워드
- Genomics
- 키워드
- Sex differences
- 키워드
- Transcriptomics
- 기타저자
- University of California, San Francisco Pharmaceutical Sciences and Pharmacogenomics
- 기본자료저록
- Dissertations Abstracts International. 85-09B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211150941
■006m o d
■007cr#unu||||||||
■020 ▼a9798381971644
■035 ▼a(MiAaPQ)AAI30991867
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a575
■1001 ▼aJonson, Caroline.▼0(orcid)0000-0001-7049-6281
■24510▼aHeterogeneities in Alzheimer's Disease and Related Dementias: Elucidating the Genetic and Transcriptomic Underpinnings
■260 ▼a[Sl]▼bUniversity of California, San Francisco▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a230 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-09, Section: B.
■500 ▼aAdvisor: Yokoyama, Jennifer.
■5021 ▼aThesis (Ph.D.)--University of California, San Francisco, 2024.
■520 ▼aDespite the tremendous burden of Alzheimer's disease and related dementias (ADRD on patients, their families, and the public health system, there are still no effective treatments for the disease. Seeking a better understanding of important disease-subgroup-specific associations in a highly heterogeneous patient population, like those diagnosed with ADRD, can help facilitate the development of new therapeutics by enhancing clinical trial design. This thesis focuses on elucidating the genetic and transcriptomic underpinnings of the heterogeneities in ADRD and where these subgroups mechanistically converge.Chapter 1 focuses on features driving sex differences in AD progression to help reveal what protects some individuals and what makes others more vulnerable, ultimately informing the development of personalized therapeutics that benefit both sexes.Chapter 2 presents a meta-analysis of Alzheimer's disease genetics across multiple ancestries and highlights the current lack of diversity in neurodegenerative disease genetic research, suggesting a need for more inclusive studies.Chapter 3 links peripheral immune changes to familial tauopathy and early-onset Alzheimer's, showing altered monocytes in tauopathies and increased interferon-responsive T cells in EOAD. This chapter highlights the importance of the immune system in ADRD.
■590 ▼aSchool code: 0034.
■650 4▼aGenetics
■650 4▼aNeurosciences
■650 4▼aPharmacology
■650 4▼aMolecular biology
■650 4▼aImmunology
■653 ▼aAncestral differences
■653 ▼aDementias
■653 ▼aGenome wide association study
■653 ▼aGenomics
■653 ▼aSex differences
■653 ▼aTranscriptomics
■690 ▼a0369
■690 ▼a0317
■690 ▼a0982
■690 ▼a0419
■690 ▼a0307
■71020▼aUniversity of California, San Francisco▼bPharmaceutical Sciences and Pharmacogenomics.
■7730 ▼tDissertations Abstracts International▼g85-09B.
■790 ▼a0034
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160245▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
