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Study of the Bio-Tribo-Mechanical Characteristics of Orthopedic-Grade Polymers
Study of the Bio-Tribo-Mechanical Characteristics of Orthopedic-Grade Polymers
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151437
- ISBN
- 9798384447542
- DDC
- 621
- 저자명
- Roy, Anurag.
- 서명/저자
- Study of the Bio-Tribo-Mechanical Characteristics of Orthopedic-Grade Polymers
- 발행사항
- [Sl] : University of California, Berkeley, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 98 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Pruitt, Lisa A.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Berkeley, 2024.
- 초록/해제
- 요약Osteoarthritis is an affliction whereby the articular cartilage present in the joint space starts to progressively degrade, causing mild to excruciating pain (depending on the stage of osteoarthritic joints) and severely affecting mobility and the quality of life of patients. Advanced stage osteoarthritic joints need a surgical intervention in the form of total joint replacement (TJR) as a 'cure'. TJRs encompass total knee replacements, total hip replacements, total shoulder replacements, and more. Ultra-high molecular weight polyethylene (UHMWPE) has been used as a bearing material in TJRs for over six decades owing to a slew of attributes it exhibits including but not limited to exceptional energetic toughness, mechanical integrity, and biocompatibility. However, given the hostile environment that the orthopedic grade polymers experience in-vivo, there are reports of TJR failure induced through wear (caused by the constant articulation of the mechanical components in TJRs), fatigue (owing to the cyclic nature of biomechanical stresses), and corrosion (given the saline ambience inside the body). Consequently, new polymer bearing materials like Polyether ether ketone (PEEK) and PEEK composites are increasingly being explored in the orthopedics community to overcome the aforementioned challenges. Alongside, there is a push towards improving the surface attributes of the TJR components given that wear, fatigue-induced wear, and corrosion are primarily surface and sub-surface phenomenon, and researchers in this field are looking into varied surface modification techniques from plasma surface treatment to coatings to post-processing and compositional changes through alloying to address persistent problems with TJRs.This thesis delves into the bio-tribo-mechanical characteristics of both of these orthopedic-grade polymers, namely, UHMWPE and PEEK. First, an overview of the fatigue of polymers with special focus on UHMWPE is provided to lay the groundwork. Next, a deep dive into the tribological, mechanical, and biocompatibility aspects of PEEK and its composites is undertaken and their suitability for use in TJRs as a potential substitute for UHMWPE is thoroughly understood. Thereafter, some initial findings concerning the fatigue crack initiation phenomenon in UHMWPE from clinically relevant stress concentrations in TJR components like notches are duly reported. Finally, a perspective on bringing about a fundamental shift in the orthopedics realm by employing surface modification techniques such as Diamond-like Carbon (DLC) overcoats on TJR components to mitigate problems such as wear, corrosion, and metal-ion release plaguing modern-day TJR systems is discussed for future researchers interested in this field.
- 일반주제명
- Mechanical engineering
- 일반주제명
- Biomedical engineering
- 일반주제명
- Materials science
- 키워드
- Osteoarthritis
- 기타저자
- University of California, Berkeley Mechanical Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008250123s2024 us c eng d■001000017161737
■00520250211151437
■006m o d
■007cr#unu||||||||
■020 ▼a9798384447542
■035 ▼a(MiAaPQ)AAI31295791
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a621
■1001 ▼aRoy, Anurag.
■24510▼aStudy of the Bio-Tribo-Mechanical Characteristics of Orthopedic-Grade Polymers
■260 ▼a[Sl]▼bUniversity of California, Berkeley▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a98 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Pruitt, Lisa A.
■5021 ▼aThesis (Ph.D.)--University of California, Berkeley, 2024.
■520 ▼aOsteoarthritis is an affliction whereby the articular cartilage present in the joint space starts to progressively degrade, causing mild to excruciating pain (depending on the stage of osteoarthritic joints) and severely affecting mobility and the quality of life of patients. Advanced stage osteoarthritic joints need a surgical intervention in the form of total joint replacement (TJR) as a 'cure'. TJRs encompass total knee replacements, total hip replacements, total shoulder replacements, and more. Ultra-high molecular weight polyethylene (UHMWPE) has been used as a bearing material in TJRs for over six decades owing to a slew of attributes it exhibits including but not limited to exceptional energetic toughness, mechanical integrity, and biocompatibility. However, given the hostile environment that the orthopedic grade polymers experience in-vivo, there are reports of TJR failure induced through wear (caused by the constant articulation of the mechanical components in TJRs), fatigue (owing to the cyclic nature of biomechanical stresses), and corrosion (given the saline ambience inside the body). Consequently, new polymer bearing materials like Polyether ether ketone (PEEK) and PEEK composites are increasingly being explored in the orthopedics community to overcome the aforementioned challenges. Alongside, there is a push towards improving the surface attributes of the TJR components given that wear, fatigue-induced wear, and corrosion are primarily surface and sub-surface phenomenon, and researchers in this field are looking into varied surface modification techniques from plasma surface treatment to coatings to post-processing and compositional changes through alloying to address persistent problems with TJRs.This thesis delves into the bio-tribo-mechanical characteristics of both of these orthopedic-grade polymers, namely, UHMWPE and PEEK. First, an overview of the fatigue of polymers with special focus on UHMWPE is provided to lay the groundwork. Next, a deep dive into the tribological, mechanical, and biocompatibility aspects of PEEK and its composites is undertaken and their suitability for use in TJRs as a potential substitute for UHMWPE is thoroughly understood. Thereafter, some initial findings concerning the fatigue crack initiation phenomenon in UHMWPE from clinically relevant stress concentrations in TJR components like notches are duly reported. Finally, a perspective on bringing about a fundamental shift in the orthopedics realm by employing surface modification techniques such as Diamond-like Carbon (DLC) overcoats on TJR components to mitigate problems such as wear, corrosion, and metal-ion release plaguing modern-day TJR systems is discussed for future researchers interested in this field.
■590 ▼aSchool code: 0028.
■650 4▼aMechanical engineering
■650 4▼aBiomedical engineering
■650 4▼aMaterials science
■653 ▼aOsteoarthritis
■653 ▼aSurgical intervention
■653 ▼aTotal joint replacement
■653 ▼aOrthopedics community
■690 ▼a0548
■690 ▼a0541
■690 ▼a0794
■71020▼aUniversity of California, Berkeley▼bMechanical Engineering.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0028
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161737▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
