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Neurobehavioral Responses to Ambiguity and Exploratory Behaviors Following Early Life Adversity
Neurobehavioral Responses to Ambiguity and Exploratory Behaviors Following Early Life Adve...
Neurobehavioral Responses to Ambiguity and Exploratory Behaviors Following Early Life Adversity

상세정보

자료유형  
 학위논문 서양
최종처리일시  
20250211153030
ISBN  
9798342745888
DDC  
150
저자명  
Saragosa-Harris, Natalie.
서명/저자  
Neurobehavioral Responses to Ambiguity and Exploratory Behaviors Following Early Life Adversity
발행사항  
[Sl] : University of California, Los Angeles, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
192 p
주기사항  
Source: Dissertations Abstracts International, Volume: 86-05, Section: B.
주기사항  
Advisor: Silvers, Jennifer Ashley.
학위논문주기  
Thesis (Ph.D.)--University of California, Los Angeles, 2024.
초록/해제  
요약Early life adversity (ELA) is a potent and common risk factor for a number of mental health challenges. ELA is thought to increase risk for psychopathology in part by sensitizing threat-responsive neural circuitry and heightening vigilance to potential threat. This hypervigilance is thought to result in a tendency to overestimate threat in the face of ambiguity or uncertainty, a core feature of several internalizing disorders. However, few studies have examined how ELA shapes neural or behavioral responses to ambiguous and uncertain stimuli. Across three studies, this dissertation integrates neuroimaging, behavioral, and self-report data to examine how ELA shapes responses to ambiguity and uncertainty. We examine these associations in children, adolescents, and emerging adults with varying histories of caregiving adversity. In Study 1 and Study 2, we use representational similarity analysis to evaluate whether similarity in neural representations of ambiguity and threat varies depending on adversity history. In Study 1, we find that emerging adults who experienced higher levels of abuse and neglect demonstrate greater representational similarity between ambiguous and threatening stimuli within threat-sensitive neurocircuitry. These results indicate that ELA may predispose an individual to represent ambiguity as threatening at the neural level. In Study 2, we sought to replicate these findings in a population of adopted youth who had experienced institutionalization in orphanage care, a rare and extreme form of caregiving adversity. However, we find that the degree of similarity in neural representations of ambiguity and threat does not significantly differ between previously institutionalized and control youth. In Study 3, we demonstrate that emerging adults who experienced higher levels of abuse and neglect exhibit less avoidance of uncertainty in an explore-exploit task. Together, these three studies provide novel insights into how ELA shapes neural and behavioral functioning in the face of the unknown and how these processes relate to wellbeing following caregiving adversity.
일반주제명  
Psychology
일반주제명  
Cognitive psychology
일반주제명  
Developmental psychology
키워드  
Early life adversity
키워드  
Exploration
키워드  
Intolerance of ambiguity
키워드  
Intolerance of uncertainty
기타저자  
University of California, Los Angeles Psychology 0780
기본자료저록  
Dissertations Abstracts International. 86-05B.
전자적 위치 및 접속  
로그인 후 원문을 볼 수 있습니다.

MARC

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■035    ▼a(MiAaPQ)AAI31635621
■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a150
■1001  ▼aSaragosa-Harris,  Natalie.
■24510▼aNeurobehavioral  Responses  to  Ambiguity  and  Exploratory  Behaviors  Following  Early  Life  Adversity
■260    ▼a[Sl]▼bUniversity  of  California,  Los  Angeles▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a192  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  86-05,  Section:  B.
■500    ▼aAdvisor:  Silvers,  Jennifer  Ashley.
■5021  ▼aThesis  (Ph.D.)--University  of  California,  Los  Angeles,  2024.
■520    ▼aEarly  life  adversity  (ELA)  is  a  potent  and  common  risk  factor  for  a  number  of  mental  health  challenges.  ELA  is  thought  to  increase  risk  for  psychopathology  in  part  by  sensitizing  threat-responsive  neural  circuitry  and  heightening  vigilance  to  potential  threat.  This  hypervigilance  is  thought  to  result  in  a  tendency  to  overestimate  threat  in  the  face  of  ambiguity  or  uncertainty,  a  core  feature  of  several  internalizing  disorders.  However,  few  studies  have  examined  how  ELA  shapes  neural  or  behavioral  responses  to  ambiguous  and  uncertain  stimuli.  Across  three  studies,  this  dissertation  integrates  neuroimaging,  behavioral,  and  self-report  data  to  examine  how  ELA  shapes  responses  to  ambiguity  and  uncertainty.  We  examine  these  associations  in  children,  adolescents,  and  emerging  adults  with  varying  histories  of  caregiving  adversity.  In  Study  1  and  Study  2,  we  use  representational  similarity  analysis  to  evaluate  whether  similarity  in  neural  representations  of  ambiguity  and  threat  varies  depending  on  adversity  history.  In  Study  1,  we  find  that  emerging  adults  who  experienced  higher  levels  of  abuse  and  neglect  demonstrate  greater  representational  similarity  between  ambiguous  and  threatening  stimuli  within  threat-sensitive  neurocircuitry.  These  results  indicate  that  ELA  may  predispose  an  individual  to  represent  ambiguity  as  threatening  at  the  neural  level.  In  Study  2,  we  sought  to  replicate  these  findings  in  a  population  of  adopted  youth  who  had  experienced  institutionalization  in  orphanage  care,  a  rare  and  extreme  form  of  caregiving  adversity.  However,  we  find  that  the  degree  of  similarity  in  neural  representations  of  ambiguity  and  threat  does  not  significantly  differ  between  previously  institutionalized  and  control  youth.  In  Study  3,  we  demonstrate  that  emerging  adults  who  experienced  higher  levels  of  abuse  and  neglect  exhibit  less  avoidance  of  uncertainty  in  an  explore-exploit  task.  Together,  these  three  studies  provide  novel  insights  into  how  ELA  shapes  neural  and  behavioral  functioning  in  the  face  of  the  unknown  and  how  these  processes  relate  to  wellbeing  following  caregiving  adversity.
■590    ▼aSchool  code:  0031.
■650  4▼aPsychology
■650  4▼aCognitive  psychology
■650  4▼aDevelopmental  psychology
■653    ▼aEarly  life  adversity
■653    ▼aExploration
■653    ▼aIntolerance  of  ambiguity
■653    ▼aIntolerance  of  uncertainty
■690    ▼a0621
■690    ▼a0633
■690    ▼a0620
■71020▼aUniversity  of  California,  Los  Angeles▼bPsychology  0780.
■7730  ▼tDissertations  Abstracts  International▼g86-05B.
■790    ▼a0031
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17164678▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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