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Next Generation Risk Assessment of Phthalates: Integrating New Approach Methods and Exposomic Approaches Using a Washington State Agricultural Community Cohort Study
Next Generation Risk Assessment of Phthalates: Integrating New Approach Methods and Exposomic Approaches Using a Washington State Agricultural Community Cohort Study
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152009
- ISBN
- 9798384096214
- DDC
- 615.9
- 저자명
- Leang, Amy.
- 서명/저자
- Next Generation Risk Assessment of Phthalates: Integrating New Approach Methods and Exposomic Approaches Using a Washington State Agricultural Community Cohort Study
- 발행사항
- [Sl] : University of Washington, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 90 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Faustman, Elaine M.
- 학위논문주기
- Thesis (Ph.D.)--University of Washington, 2024.
- 초록/해제
- 요약This dissertation explores phthalate exposure trends, associated health effects, and using new approach methods (NAMs) to fill data gaps for an agricultural community cohort in the Lower Yakima Valley of Washington State. Phthalates are a ubiquitous group of chemicals present in the environment. Only a few have been thoroughly analyzed and approaches to evaluating their risks are currently being evaluated by federal agencies. The first objective of this dissertation was to utilize the University of Washington Center for Child Environmental Health Risks Research (CHC) dust exposome, open data, and computational toxicology tools to assess the potential for hazards of phthalates based on real-life exposure estimates. We found that open data sources can be used to screen chemicals for risk assessment purposes and are relevant for the CHC agricultural community cohort. The second objective was to determine whether children's product reporting requirements and regulations at the state and federal level are associated with longitudinal changes in phthalate concentrations. Based on samples of household dust collected from the Child Health Center (CHC) cohort in 2005 and 2011, we observed significant longitudinal and seasonal changes in phthalate concentrations for most of the 16 study phthalates. These changes may be attributable to increased regulations, agricultural spray activities, or other environmental and behavioral factors affecting levels in dust. Collectively, this research demonstrates increased utility of NAMs to promote next generation risk assessment approaches in data-poor chemicals, as well as underscores the complexities of environmental exposures to phthalates that are dynamic in nature.
- 일반주제명
- Toxicology
- 일반주제명
- Environmental health
- 일반주제명
- Environmental science
- 키워드
- Phthalates
- 기타저자
- University of Washington Environmental and Occupational Health Sciences
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798384096214
■035 ▼a(MiAaPQ)AAI31330984
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a615.9
■1001 ▼aLeang, Amy.
■24510▼aNext Generation Risk Assessment of Phthalates: Integrating New Approach Methods and Exposomic Approaches Using a Washington State Agricultural Community Cohort Study
■260 ▼a[Sl]▼bUniversity of Washington▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a90 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Faustman, Elaine M.
■5021 ▼aThesis (Ph.D.)--University of Washington, 2024.
■520 ▼aThis dissertation explores phthalate exposure trends, associated health effects, and using new approach methods (NAMs) to fill data gaps for an agricultural community cohort in the Lower Yakima Valley of Washington State. Phthalates are a ubiquitous group of chemicals present in the environment. Only a few have been thoroughly analyzed and approaches to evaluating their risks are currently being evaluated by federal agencies. The first objective of this dissertation was to utilize the University of Washington Center for Child Environmental Health Risks Research (CHC) dust exposome, open data, and computational toxicology tools to assess the potential for hazards of phthalates based on real-life exposure estimates. We found that open data sources can be used to screen chemicals for risk assessment purposes and are relevant for the CHC agricultural community cohort. The second objective was to determine whether children's product reporting requirements and regulations at the state and federal level are associated with longitudinal changes in phthalate concentrations. Based on samples of household dust collected from the Child Health Center (CHC) cohort in 2005 and 2011, we observed significant longitudinal and seasonal changes in phthalate concentrations for most of the 16 study phthalates. These changes may be attributable to increased regulations, agricultural spray activities, or other environmental and behavioral factors affecting levels in dust. Collectively, this research demonstrates increased utility of NAMs to promote next generation risk assessment approaches in data-poor chemicals, as well as underscores the complexities of environmental exposures to phthalates that are dynamic in nature.
■590 ▼aSchool code: 0250.
■650 4▼aToxicology
■650 4▼aEnvironmental health
■650 4▼aEnvironmental science
■653 ▼aNew approach methods
■653 ▼aChild Health Center
■653 ▼aPhthalates
■653 ▼aExposomic approaches
■653 ▼aAgricultural community cohort
■690 ▼a0383
■690 ▼a0470
■690 ▼a0768
■71020▼aUniversity of Washington▼bEnvironmental and Occupational Health Sciences.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0250
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162411▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
