서브메뉴
검색
Protein Nanomaterials as Tools for Cryo-EM Structural Analysis
Protein Nanomaterials as Tools for Cryo-EM Structural Analysis
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152012
- ISBN
- 9798382837307
- DDC
- 574
- 서명/저자
- Protein Nanomaterials as Tools for Cryo-EM Structural Analysis
- 발행사항
- [Sl] : University of California, Los Angeles, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 228 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Advisor: Rodriguez, Jose Alfonso.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2024.
- 초록/해제
- 요약In the last few decades there has been tremendous technological and computational advances in the field of cryo-electron microscopy which has led to a phenomena referred to as "The Resolution Revolution," in which the number of high resolution structures solved via this technique has exploded. Despite these advances, there still remains a size limitation for your target of interest, below which high resolution microscopy remains challenging. Adding to this, a vast majority of the biologically relevant proteins and nucleic acids inside of cells lie below this size limit. Parallel advances in protein design may provide an avenue for progress on this challenging problem. By designing large protein assemblies, we are able to artificially increase the size of a given target, making it amenable to cryo-EM studies. This thesis describes recent advances in the field as well as efforts to generate imaging scaffolds for both small cancer-related protein targets, and RNA molecules. The knowledge gained through these endeavors will better guide future design efforts.
- 일반주제명
- Biochemistry
- 일반주제명
- Oncology
- 일반주제명
- Genetics
- 일반주제명
- Nanoscience
- 키워드
- Cryo-EM
- 키워드
- Crystallography
- 키워드
- Protein design
- 키워드
- RNA
- 키워드
- Scaffolds
- 기타저자
- University of California, Los Angeles Biochemistry Molecular and Structural Biology 0090
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008250123s2024 us c eng d■001000017162438
■00520250211152012
■006m o d
■007cr#unu||||||||
■020 ▼a9798382837307
■035 ▼a(MiAaPQ)AAI31331326
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aAgdanowski, Matthew Paul.
■24510▼aProtein Nanomaterials as Tools for Cryo-EM Structural Analysis
■260 ▼a[Sl]▼bUniversity of California, Los Angeles▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a228 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: Rodriguez, Jose Alfonso.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2024.
■520 ▼aIn the last few decades there has been tremendous technological and computational advances in the field of cryo-electron microscopy which has led to a phenomena referred to as "The Resolution Revolution," in which the number of high resolution structures solved via this technique has exploded. Despite these advances, there still remains a size limitation for your target of interest, below which high resolution microscopy remains challenging. Adding to this, a vast majority of the biologically relevant proteins and nucleic acids inside of cells lie below this size limit. Parallel advances in protein design may provide an avenue for progress on this challenging problem. By designing large protein assemblies, we are able to artificially increase the size of a given target, making it amenable to cryo-EM studies. This thesis describes recent advances in the field as well as efforts to generate imaging scaffolds for both small cancer-related protein targets, and RNA molecules. The knowledge gained through these endeavors will better guide future design efforts.
■590 ▼aSchool code: 0031.
■650 4▼aBiochemistry
■650 4▼aOncology
■650 4▼aGenetics
■650 4▼aNanoscience
■653 ▼aCryo-EM
■653 ▼aCrystallography
■653 ▼aProtein design
■653 ▼aRNA
■653 ▼aScaffolds
■690 ▼a0487
■690 ▼a0565
■690 ▼a0992
■690 ▼a0369
■71020▼aUniversity of California, Los Angeles▼bBiochemistry, Molecular and Structural Biology 0090.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162438▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
