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Molecular Tuning of Sea Anemone Stinging
Molecular Tuning of Sea Anemone Stinging
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151002
- ISBN
- 9798382777665
- DDC
- 616
- 저자명
- He, Lily.
- 서명/저자
- Molecular Tuning of Sea Anemone Stinging
- 발행사항
- [Sl] : Harvard University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 165 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Advisor: Bellono, Nicholas.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2024.
- 초록/해제
- 요약The judicious control of behavior in response to environmental cues is key to survival for all living creatures. We choose to study sensory transduction and behavior regulation in cnidarians like jellyfish and anemones because they present as an attractive system with decentralized nervous systems and a unique "all-or-nothing" stinging behavior. Cnidarians use specialized cells called nematocytes to shoot single-use, venom-covered barbs to envenomate prey or predators. How do different cnidarians control stinging for different purposes like predation versus defense? We previously showed that the anemone Nematostella vectensis uses a specialized voltage-gated calcium (CaV) channel to trigger stinging in response to synergistic prey-derived chemicals and touch (Weir et al., 2020). Here we use experiments and theory to reveal that stinging behavior is suited to distinct ecological niches. While the burrowing anemone Nematostella uses uniquely strong CaV inactivation for precise control of predatory stinging, the related anemone Exaiptasia diaphana, which inhabits exposed environments to support photosynthetic endosymbionts, stings indiscriminately for self-defense. Consistent with their indiscriminate stinging behavior, Exaiptasia nematocytes express a CaV splice variant that confers weak CaV inactivation. Chimeric analyses of jellyfish and anemone CaVs revealed that differences in inactivation are mediated by the CaVβ subunit N-terminus. These findings reveal a molecular control mechanism for cnidarian stinging and demonstrate how evolutionary tuning of ion channel structure suits distinct signal processing and behavior.
- 일반주제명
- Neurosciences
- 일반주제명
- Physiology
- 일반주제명
- Evolution & development
- 키워드
- Adaptation
- 키워드
- Calcium channel
- 키워드
- Cnidarian
- 키워드
- Inactivation
- 키워드
- Stinging
- 기타저자
- Harvard University Medical Sciences
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211151002
■006m o d
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■020 ▼a9798382777665
■035 ▼a(MiAaPQ)AAI30994130
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aHe, Lily.▼0(orcid)0000-0003-2987-3393
■24510▼aMolecular Tuning of Sea Anemone Stinging
■260 ▼a[Sl]▼bHarvard University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a165 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: Bellono, Nicholas.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2024.
■520 ▼aThe judicious control of behavior in response to environmental cues is key to survival for all living creatures. We choose to study sensory transduction and behavior regulation in cnidarians like jellyfish and anemones because they present as an attractive system with decentralized nervous systems and a unique "all-or-nothing" stinging behavior. Cnidarians use specialized cells called nematocytes to shoot single-use, venom-covered barbs to envenomate prey or predators. How do different cnidarians control stinging for different purposes like predation versus defense? We previously showed that the anemone Nematostella vectensis uses a specialized voltage-gated calcium (CaV) channel to trigger stinging in response to synergistic prey-derived chemicals and touch (Weir et al., 2020). Here we use experiments and theory to reveal that stinging behavior is suited to distinct ecological niches. While the burrowing anemone Nematostella uses uniquely strong CaV inactivation for precise control of predatory stinging, the related anemone Exaiptasia diaphana, which inhabits exposed environments to support photosynthetic endosymbionts, stings indiscriminately for self-defense. Consistent with their indiscriminate stinging behavior, Exaiptasia nematocytes express a CaV splice variant that confers weak CaV inactivation. Chimeric analyses of jellyfish and anemone CaVs revealed that differences in inactivation are mediated by the CaVβ subunit N-terminus. These findings reveal a molecular control mechanism for cnidarian stinging and demonstrate how evolutionary tuning of ion channel structure suits distinct signal processing and behavior.
■590 ▼aSchool code: 0084.
■650 4▼aNeurosciences
■650 4▼aPhysiology
■650 4▼aEvolution & development
■653 ▼aAdaptation
■653 ▼aCalcium channel
■653 ▼aCnidarian
■653 ▼aInactivation
■653 ▼aStinging
■690 ▼a0317
■690 ▼a0412
■690 ▼a0719
■71020▼aHarvard University▼bMedical Sciences.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160350▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
