Computational Fluid-Structure Interaction Modeling of the Cardiovascular System
Computational Fluid-Structure Interaction Modeling of the Cardiovascular System
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152031
- ISBN
- 9798384022763
- DDC
- 621
- 서명/저자
- Computational Fluid-Structure Interaction Modeling of the Cardiovascular System
- 발행사항
- [Sl] : University of Pennsylvania, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 236 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
- 주기사항
- Advisor: Park, George Ilhwan.
- 학위논문주기
- Thesis (Ph.D.)--University of Pennsylvania, 2024.
- 초록/해제
- 요약Patient-specific computational modeling and simulation has become a routine part of cardiovascular clinical research. These techniques leverage medical imaging to construct subject-specific models that can be used to study disease processes, design and evaluate medical devices, perform predictive surgery, and aid in clinical decision-making. Modern cardiovascular simulations often require millions of elements and tens of thousands of time steps. Incorporation of additional physics only contributes to these costs and increases model complexity. Due to the presence of complex pulsatile hemodynamics potentially coupled with deformable vessel walls or heart valves, development of accurate, robust, and efficient cardiovascular simulation tools remains a challenging task. In this thesis, I present several improvements to existing finite element solver technologies for computational modeling of the cardiovascular system, all of which were implemented in a new computational FSI framework I developed in the Modular Finite Elements Methods (MFEM) C++ library. First, I describe a block preconditioning technique for implicit time discretization of the Navier-Stokes equations monolithically coupled to reduced dimension models of the cardiovascular system (e.g. Windkessel model). Mass conservation properties of various solution algorithms are investigated in a patient-specific aorta model. Next, I show how these improved techniques can be leveraged to simulate FSI problems, such as blood flow through deformable vessels, using the arbitrary Lagrangian-Eulerian method combined with a quasi-Newton solution procedure. Lastly, I present an immersed approach for computational modeling of fluid-structure interaction. A fully implicit monolithic coupling method is described, as well as several discretization improvements targeted for immersed thin structures. I demonstrate the potential of the method to simulate heart valve dynamics over the cardiac cycle using an idealized problem and two extensions: heterogeneous valves as a simplified model for calcification, as well as an anisotropic Fung type constitutive model for the leaflets.
- 일반주제명
- Mechanical engineering
- 일반주제명
- Biomechanics
- 일반주제명
- Computational physics
- 일반주제명
- Biomedical engineering
- 일반주제명
- Fluid mechanics
- 키워드
- Immersed methods
- 기타저자
- University of Pennsylvania Mechanical Engineering and Applied Mechanics
- 기본자료저록
- Dissertations Abstracts International. 86-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798384022763
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a621
■1001 ▼aBlack, Ryan Thomas.
■24510▼aComputational Fluid-Structure Interaction Modeling of the Cardiovascular System
■260 ▼a[Sl]▼bUniversity of Pennsylvania▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a236 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-02, Section: B.
■500 ▼aAdvisor: Park, George Ilhwan.
■5021 ▼aThesis (Ph.D.)--University of Pennsylvania, 2024.
■520 ▼aPatient-specific computational modeling and simulation has become a routine part of cardiovascular clinical research. These techniques leverage medical imaging to construct subject-specific models that can be used to study disease processes, design and evaluate medical devices, perform predictive surgery, and aid in clinical decision-making. Modern cardiovascular simulations often require millions of elements and tens of thousands of time steps. Incorporation of additional physics only contributes to these costs and increases model complexity. Due to the presence of complex pulsatile hemodynamics potentially coupled with deformable vessel walls or heart valves, development of accurate, robust, and efficient cardiovascular simulation tools remains a challenging task. In this thesis, I present several improvements to existing finite element solver technologies for computational modeling of the cardiovascular system, all of which were implemented in a new computational FSI framework I developed in the Modular Finite Elements Methods (MFEM) C++ library. First, I describe a block preconditioning technique for implicit time discretization of the Navier-Stokes equations monolithically coupled to reduced dimension models of the cardiovascular system (e.g. Windkessel model). Mass conservation properties of various solution algorithms are investigated in a patient-specific aorta model. Next, I show how these improved techniques can be leveraged to simulate FSI problems, such as blood flow through deformable vessels, using the arbitrary Lagrangian-Eulerian method combined with a quasi-Newton solution procedure. Lastly, I present an immersed approach for computational modeling of fluid-structure interaction. A fully implicit monolithic coupling method is described, as well as several discretization improvements targeted for immersed thin structures. I demonstrate the potential of the method to simulate heart valve dynamics over the cardiac cycle using an idealized problem and two extensions: heterogeneous valves as a simplified model for calcification, as well as an anisotropic Fung type constitutive model for the leaflets.
■590 ▼aSchool code: 0175.
■650 4▼aMechanical engineering
■650 4▼aBiomechanics
■650 4▼aComputational physics
■650 4▼aBiomedical engineering
■650 4▼aFluid mechanics
■653 ▼aArbitrary Lagrangian-Eulerian method
■653 ▼aCardiovascular flows
■653 ▼aFinite element methods
■653 ▼aFluid-structure interaction
■653 ▼aHeart valve modeling
■653 ▼aImmersed methods
■690 ▼a0548
■690 ▼a0648
■690 ▼a0216
■690 ▼a0541
■690 ▼a0204
■71020▼aUniversity of Pennsylvania▼bMechanical Engineering and Applied Mechanics.
■7730 ▼tDissertations Abstracts International▼g86-02B.
■790 ▼a0175
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162597▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
