Development of Data-Integrated Multiphysics In Silico Modeling Techniques for Blood Clot Mechanics and Clot-Flow Interactions
Development of Data-Integrated Multiphysics In Silico Modeling Techniques for Blood Clot Mechanics and Clot-Flow Interactions
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152700
- ISBN
- 9798384051817
- DDC
- 620
- 서명/저자
- Development of Data-Integrated Multiphysics In Silico Modeling Techniques for Blood Clot Mechanics and Clot-Flow Interactions
- 발행사항
- [Sl] : University of Colorado at Boulder, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 169 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Mukherjee, Debanjan.
- 학위논문주기
- Thesis (Ph.D.)--University of Colorado at Boulder, 2024.
- 초록/해제
- 요약Pathological blood clotting, or thrombosis, is the primary cause or complication in stroke and other severe cardiovascular diseases. Complications arise when a blood clot (thrombus) obstructs blood flow in key vessels. Local hemodynamics within a clot are central to clot growth, disease progression, and thrombolysis. Despite its significance, quantifying clot-flow interactions remains challenging due to the inherently multi-scale nature of realistic blood clots. At the macro-scale, pulsatile hemodynamics induce loading on a heterogeneous blood clot, resulting in a highly non-linear flow structure and clot deformation. At the micro-scale, a blood clot is an aggregate of platelets and fibrin fibers, forming a highly heterogeneous porous structure. These microstructural features play a significant role in flow-driven permeation and transport within the clot. Simultaneously resolving clot-flow interactions at both scales remains a challenge.To address these challenges, we developed novel numerical modeling methodologies that simulate clot-flow interactions while simultaneously accounting for blood clot microstructural features. In this contribution, we present our multi-scale approach to simulating blood clot-hemodynamics interactions which directly model clot microstructural features. We present two modeling strategies to account for blood clot dynamic deformation: (a) We devised a modeling strategy that couples dynamic clot deformation obtained directly from in vivo microscopy experiments. We demonstrated our proposed method on two different blood clot phenotypes, illustrating its efficacy in recovering local hemodynamics data and other flow-derived quantities that are otherwise unavailable from imaging alone; (b) We developed a two-way coupled fluid-structure interaction model that directly predict heterogeneous blood clot dynamics under pulsatile flow. We demonstrate that our model can recreate the realistic blood clot contraction behavior observed in vivo.
- 일반주제명
- Fluid mechanics
- 일반주제명
- Biomechanics
- 일반주제명
- Computational physics
- 일반주제명
- Mechanical engineering
- 키워드
- Blood clots
- 키워드
- Hemodynamics
- 키워드
- Thrombosis
- 기타저자
- University of Colorado at Boulder Mechanical Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798384051817
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a620
■1001 ▼aTeeraratkul, Chayut.▼0(orcid)0000-0002-0175-8070
■24510▼aDevelopment of Data-Integrated Multiphysics In Silico Modeling Techniques for Blood Clot Mechanics and Clot-Flow Interactions
■260 ▼a[Sl]▼bUniversity of Colorado at Boulder▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a169 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Mukherjee, Debanjan.
■5021 ▼aThesis (Ph.D.)--University of Colorado at Boulder, 2024.
■520 ▼aPathological blood clotting, or thrombosis, is the primary cause or complication in stroke and other severe cardiovascular diseases. Complications arise when a blood clot (thrombus) obstructs blood flow in key vessels. Local hemodynamics within a clot are central to clot growth, disease progression, and thrombolysis. Despite its significance, quantifying clot-flow interactions remains challenging due to the inherently multi-scale nature of realistic blood clots. At the macro-scale, pulsatile hemodynamics induce loading on a heterogeneous blood clot, resulting in a highly non-linear flow structure and clot deformation. At the micro-scale, a blood clot is an aggregate of platelets and fibrin fibers, forming a highly heterogeneous porous structure. These microstructural features play a significant role in flow-driven permeation and transport within the clot. Simultaneously resolving clot-flow interactions at both scales remains a challenge.To address these challenges, we developed novel numerical modeling methodologies that simulate clot-flow interactions while simultaneously accounting for blood clot microstructural features. In this contribution, we present our multi-scale approach to simulating blood clot-hemodynamics interactions which directly model clot microstructural features. We present two modeling strategies to account for blood clot dynamic deformation: (a) We devised a modeling strategy that couples dynamic clot deformation obtained directly from in vivo microscopy experiments. We demonstrated our proposed method on two different blood clot phenotypes, illustrating its efficacy in recovering local hemodynamics data and other flow-derived quantities that are otherwise unavailable from imaging alone; (b) We developed a two-way coupled fluid-structure interaction model that directly predict heterogeneous blood clot dynamics under pulsatile flow. We demonstrate that our model can recreate the realistic blood clot contraction behavior observed in vivo.
■590 ▼aSchool code: 0051.
■650 4▼aFluid mechanics
■650 4▼aBiomechanics
■650 4▼aComputational physics
■650 4▼aMechanical engineering
■653 ▼aDiscrete Element Method
■653 ▼aBlood clots
■653 ▼aFluid-structure interaction
■653 ▼aHemodynamics
■653 ▼aThrombosis
■690 ▼a0204
■690 ▼a0648
■690 ▼a0216
■690 ▼a0548
■71020▼aUniversity of Colorado at Boulder▼bMechanical Engineering.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0051
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17163380▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
