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Understanding Cognitive and Psychopathological Variability: The Role of Individual Differences in Machine Learning Applications
Understanding Cognitive and Psychopathological Variability: The Role of Individual Differences in Machine Learning Applications
Detailed Information
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151323
- ISBN
- 9798382757803
- DDC
- 153
- 서명/저자
- Understanding Cognitive and Psychopathological Variability: The Role of Individual Differences in Machine Learning Applications
- 발행사항
- [Sl] : Northwestern University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 187 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
- 주기사항
- Advisor: Gratton, Caterina.
- 학위논문주기
- Thesis (Ph.D.)--Northwestern University, 2024.
- 초록/해제
- 요약The study of psychiatric disorders often involves tracking changes in brain function as it relates to symptoms. While research has found significant differences in functional network organization as it relates to various clinical outcomes, the exact neural biomarkers that contribute to symptom severity is often inconsistent. Prior research has shown that methodological considerations in sample size, motion artifacts, and increasing data quantity at the individual level can lead to substantial improvements in reliability. In Chapter 1, I provide a brief overview on existing work surrounding different methodological approaches that improve prediction of behavioral variables from brain network data. In the next three chapters, I describe research projects that aimed to use different cutting-edge approaches to improve machine learning prediction of behavior. In Chapter 2, I tested whether machine learning classification can improve our understanding of how brain networks are altered during tasks by using an individual specific approach. I found that individual focused approaches can uncover robust features of brain states, including features obscured in cross-subject analyses. In Chapter 3 I asked whether prediction of Schizophrenia Spectrum Disorders could be improved by joining together different neuroimaging modalities. I conducted a meta-analysis and systematic review of the existing literature and found no significant evidence for an advantage of multimodal relative to unimodal imaging approaches. However, this result could have been driven by biased effect sizes, particularly highlighting the need for improvements in data quality and quantity. In Chapter 4 I sought to test whether the prediction of clinical (especially psychosis) and cognitive measures from brain network data could be improved by either using person-specific parcellations or extended amounts of data from each participant. I found that increasing the quantity of data at the individual level exhibited significant improvements at predicting clinical and cognitive measures compared to resting state models, with only smaller scale effects associated with individual parcellations. Finally, in Chapter 5 I provide a brief general discussion to highlight the contributions of this work and future directions.
- 일반주제명
- Cognitive psychology
- 일반주제명
- Neurosciences
- 일반주제명
- Computer science
- 일반주제명
- Medical imaging
- 키워드
- Psychosis
- 키워드
- Machine learning
- 기타저자
- Northwestern University Psychology
- 기본자료저록
- Dissertations Abstracts International. 85-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211151323
■006m o d
■007cr#unu||||||||
■020 ▼a9798382757803
■035 ▼a(MiAaPQ)AAI31239665
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a153
■1001 ▼aPorter, Alexis Grace.
■24510▼aUnderstanding Cognitive and Psychopathological Variability: The Role of Individual Differences in Machine Learning Applications
■260 ▼a[Sl]▼bNorthwestern University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a187 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-11, Section: B.
■500 ▼aAdvisor: Gratton, Caterina.
■5021 ▼aThesis (Ph.D.)--Northwestern University, 2024.
■520 ▼aThe study of psychiatric disorders often involves tracking changes in brain function as it relates to symptoms. While research has found significant differences in functional network organization as it relates to various clinical outcomes, the exact neural biomarkers that contribute to symptom severity is often inconsistent. Prior research has shown that methodological considerations in sample size, motion artifacts, and increasing data quantity at the individual level can lead to substantial improvements in reliability. In Chapter 1, I provide a brief overview on existing work surrounding different methodological approaches that improve prediction of behavioral variables from brain network data. In the next three chapters, I describe research projects that aimed to use different cutting-edge approaches to improve machine learning prediction of behavior. In Chapter 2, I tested whether machine learning classification can improve our understanding of how brain networks are altered during tasks by using an individual specific approach. I found that individual focused approaches can uncover robust features of brain states, including features obscured in cross-subject analyses. In Chapter 3 I asked whether prediction of Schizophrenia Spectrum Disorders could be improved by joining together different neuroimaging modalities. I conducted a meta-analysis and systematic review of the existing literature and found no significant evidence for an advantage of multimodal relative to unimodal imaging approaches. However, this result could have been driven by biased effect sizes, particularly highlighting the need for improvements in data quality and quantity. In Chapter 4 I sought to test whether the prediction of clinical (especially psychosis) and cognitive measures from brain network data could be improved by either using person-specific parcellations or extended amounts of data from each participant. I found that increasing the quantity of data at the individual level exhibited significant improvements at predicting clinical and cognitive measures compared to resting state models, with only smaller scale effects associated with individual parcellations. Finally, in Chapter 5 I provide a brief general discussion to highlight the contributions of this work and future directions.
■590 ▼aSchool code: 0163.
■650 4▼aCognitive psychology
■650 4▼aNeurosciences
■650 4▼aComputer science
■650 4▼aMedical imaging
■653 ▼aCognitive measures
■653 ▼aPsychosis
■653 ▼aClinical outcomes
■653 ▼aIndividual differences
■653 ▼aMachine learning
■690 ▼a0633
■690 ▼a0984
■690 ▼a0574
■690 ▼a0800
■690 ▼a0317
■71020▼aNorthwestern University▼bPsychology.
■7730 ▼tDissertations Abstracts International▼g85-11B.
■790 ▼a0163
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161196▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
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