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Self-Extinguishing Relay Waves Enable Homeostatic Control of Human Neutrophil Swarming
Self-Extinguishing Relay Waves Enable Homeostatic Control of Human Neutrophil Swarming
Detailed Information
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151329
- ISBN
- 9798382815923
- DDC
- 574
- 서명/저자
- Self-Extinguishing Relay Waves Enable Homeostatic Control of Human Neutrophil Swarming
- 발행사항
- [Sl] : University of California, San Francisco, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 87 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Includes supplementary digital materials.
- 주기사항
- Advisor: Weiner, Orion.
- 학위논문주기
- Thesis (Ph.D.)--University of California, San Francisco, 2024.
- 초록/해제
- 요약Neutrophils collectively migrate to sites of injury and infection. How these swarms are coordinated to ensure the proper level of recruitment is unknown. Using an ex vivo model of infection, we show that human neutrophil swarming is organized by multiple pulsatile chemoattractant waves. These waves propagate through active relay in which stimulated neutrophils trigger their neighbors to release additional swarming cues. Unlike canonical active relays, we find these waves to be self-terminating, limiting the spatial range of cell recruitment. We identify an NADPH-oxidase-based negative feedback loop that is needed for this self-terminating behavior. We observe near-constant levels of neutrophil recruitment over a wide range of starting conditions, revealing surprising robustness in the swarming process. This homeostatic control is achieved by larger and more numerous swarming waves at lower cell densities. We link defective wave termination to a broken recruitment homeostat in the context of human chronic granulomatous disease.
- 일반주제명
- Cellular biology
- 일반주제명
- Immunology
- 일반주제명
- Neurosciences
- 일반주제명
- Biophysics
- 키워드
- Active relay
- 키워드
- Chemotaxis
- 키워드
- Neutrophils
- 키워드
- Swarming process
- 기타저자
- University of California, San Francisco Biophysics
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211151329
■006m o d
■007cr#unu||||||||
■020 ▼a9798382815923
■035 ▼a(MiAaPQ)AAI31240698
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aStrickland, Evelyn.▼0(orcid)0000-0001-5131-5174
■24510▼aSelf-Extinguishing Relay Waves Enable Homeostatic Control of Human Neutrophil Swarming
■260 ▼a[Sl]▼bUniversity of California, San Francisco▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a87 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aIncludes supplementary digital materials.
■500 ▼aAdvisor: Weiner, Orion.
■5021 ▼aThesis (Ph.D.)--University of California, San Francisco, 2024.
■520 ▼aNeutrophils collectively migrate to sites of injury and infection. How these swarms are coordinated to ensure the proper level of recruitment is unknown. Using an ex vivo model of infection, we show that human neutrophil swarming is organized by multiple pulsatile chemoattractant waves. These waves propagate through active relay in which stimulated neutrophils trigger their neighbors to release additional swarming cues. Unlike canonical active relays, we find these waves to be self-terminating, limiting the spatial range of cell recruitment. We identify an NADPH-oxidase-based negative feedback loop that is needed for this self-terminating behavior. We observe near-constant levels of neutrophil recruitment over a wide range of starting conditions, revealing surprising robustness in the swarming process. This homeostatic control is achieved by larger and more numerous swarming waves at lower cell densities. We link defective wave termination to a broken recruitment homeostat in the context of human chronic granulomatous disease.
■590 ▼aSchool code: 0034.
■650 4▼aCellular biology
■650 4▼aImmunology
■650 4▼aNeurosciences
■650 4▼aBiophysics
■653 ▼aActive relay
■653 ▼aChemotaxis
■653 ▼aCollective migration
■653 ▼aNeutrophils
■653 ▼aSwarming process
■690 ▼a0379
■690 ▼a0982
■690 ▼a0786
■690 ▼a0317
■71020▼aUniversity of California, San Francisco▼bBiophysics.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0034
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161241▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
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