Enhancing Joint Health: Tribological Characterization of Lubricants for Articular Cartilage
Enhancing Joint Health: Tribological Characterization of Lubricants for Articular Cartilage
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152040
- ISBN
- 9798384049906
- DDC
- 620.8
- 서명/저자
- Enhancing Joint Health: Tribological Characterization of Lubricants for Articular Cartilage
- 발행사항
- [Sl] : Cornell University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 214 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Bonassar, Lawrence.
- 학위논문주기
- Thesis (Ph.D.)--Cornell University, 2024.
- 초록/해제
- 요약Articular cartilage is one of the most remarkable load bearing materials found in nature. Its unique composition provides some of the lowest friction coefficients ever measured and allows nearly frictionless articulation of our bodies' joints. However, the breakdown and degeneration of cartilage in osteoarthritis is one of the leading causes of severe disability in the industrialized world, and no effective disease-modifying treatments are currently available. With this in mind, fully understanding how the mechanisms of cartilage lubrication change between health and disease can provide insight to develop new injectable materials targeted at lowering friction and restoring proper joint function.Despite the critical role of lubrication to joint health, evaluation of synovial fluid lubrication in disease on the acute timescale is limited. Specifically, it is unclear how temporal alterations in the critical synovial fluid lubricants, lubricin and hyaluronic acid (HA), affect the lubricating properties of pathological synovial fluid. Therefore, the overarching goal of this dissertation is to characterize the tribological properties of pathological synovial fluids and new materials to be used as lubrication therapies for cartilage. In this dissertation, Chapter 1 reviews the biologic and mechanical effects of commercially available HA viscosupplements. Chapter 2 uses the Stribeck framework to show that inflamed synovial fluid exhibits changes in friction modes and effective lubricating viscosities in a temporal manner, highlighting a critical time window where viscosupplements could be most beneficial in lowering friction. Chapters 3, 4, and 5 reveal that synthetic materials can effectively lubricate healthy and osteoarthritic cartilage. Chapter 4 further elucidates how injectable materials are not evenly distributed inside a joint after administration, and that the mechanical outcomes of these therapies is strongly linked to the ability of the material to localize to the cartilage surfaces inside a joint. Collectively these findings inform the design of a new class of viscosupplements and therapeutics to treat mild to moderate OA.
- 일반주제명
- Biomechanics
- 일반주제명
- Biomedical engineering
- 일반주제명
- Materials science
- 키워드
- Lubrication
- 키워드
- Tribology
- 기타저자
- Cornell University Materials Science and Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798384049906
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a620.8
■1001 ▼aVishwanath, Karan.▼0(orcid)0000-0003-2910-9176
■24510▼aEnhancing Joint Health: Tribological Characterization of Lubricants for Articular Cartilage
■260 ▼a[Sl]▼bCornell University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a214 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Bonassar, Lawrence.
■5021 ▼aThesis (Ph.D.)--Cornell University, 2024.
■520 ▼aArticular cartilage is one of the most remarkable load bearing materials found in nature. Its unique composition provides some of the lowest friction coefficients ever measured and allows nearly frictionless articulation of our bodies' joints. However, the breakdown and degeneration of cartilage in osteoarthritis is one of the leading causes of severe disability in the industrialized world, and no effective disease-modifying treatments are currently available. With this in mind, fully understanding how the mechanisms of cartilage lubrication change between health and disease can provide insight to develop new injectable materials targeted at lowering friction and restoring proper joint function.Despite the critical role of lubrication to joint health, evaluation of synovial fluid lubrication in disease on the acute timescale is limited. Specifically, it is unclear how temporal alterations in the critical synovial fluid lubricants, lubricin and hyaluronic acid (HA), affect the lubricating properties of pathological synovial fluid. Therefore, the overarching goal of this dissertation is to characterize the tribological properties of pathological synovial fluids and new materials to be used as lubrication therapies for cartilage. In this dissertation, Chapter 1 reviews the biologic and mechanical effects of commercially available HA viscosupplements. Chapter 2 uses the Stribeck framework to show that inflamed synovial fluid exhibits changes in friction modes and effective lubricating viscosities in a temporal manner, highlighting a critical time window where viscosupplements could be most beneficial in lowering friction. Chapters 3, 4, and 5 reveal that synthetic materials can effectively lubricate healthy and osteoarthritic cartilage. Chapter 4 further elucidates how injectable materials are not evenly distributed inside a joint after administration, and that the mechanical outcomes of these therapies is strongly linked to the ability of the material to localize to the cartilage surfaces inside a joint. Collectively these findings inform the design of a new class of viscosupplements and therapeutics to treat mild to moderate OA.
■590 ▼aSchool code: 0058.
■650 4▼aBiomechanics
■650 4▼aBiomedical engineering
■650 4▼aMaterials science
■653 ▼aCartilage surfaces
■653 ▼aLubrication
■653 ▼aTribology
■653 ▼aArticular cartilage
■690 ▼a0794
■690 ▼a0648
■690 ▼a0541
■71020▼aCornell University▼bMaterials Science and Engineering.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0058
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162673▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
