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Physical Activity and Breast Tumor Biology Among Breast Cancer Survivors
Physical Activity and Breast Tumor Biology Among Breast Cancer Survivors
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103104
- ISBN
- 9798315703532
- DDC
- 614.4
- 서명/저자
- Physical Activity and Breast Tumor Biology Among Breast Cancer Survivors
- 발행사항
- [Sl] : The University of North Carolina at Chapel Hill, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 136 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
- 주기사항
- Advisor: Troester, Melissa A.
- 학위논문주기
- Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2024.
- 초록/해제
- 요약Background: Moderate to vigorous physical activity (MVPA) is associated with improved breast cancer survival, yet few studies have assessed the demographic, social, and clinical factors of MVPA across a diverse group of survivors. Black women report lower MVPA levels, are diagnosed with more aggressive cancers, and have overall higher mortality. Breast cancer outcomes could be attributed to biological markers (e.g., immune response and risk of recurrence score), although the role of MVPA in these pathways is unclear. Understanding patterns and correlates of MVPA in a diverse population of breast cancer survivors may improve recommendations and treatment allocation.Methods: This project leveraged the Carolina Breast Cancer Study Phase 3 (CBCS3; Aim 1: Longitudinal study Naim1=2,994; Aim 2: Cross-sectional study Naim2=1,424). CBCS3 is a population-based study that oversampled black and young women (50 years). This project had two aims: 1) to describe MVPA patterns and their correlates, and 2) to examine associations between pre-diagnosis MVPA and tumor molecular signature overall and stratified by estrogen receptor (ER) status.Results: In Aim 1, 83% of participants who reported MVPA pre-diagnosis experienced a decline at 6-month post-diagnosis. However, a higher proportion (85%) of these participants rebounded their MVPA at 18-month post-diagnosis compared to those who reported no MVPA pre-diagnosis. Demographic, social, and clinical correlates such as income $30K, community-level SES, and chemotherapy were significantly associated with A) higher likelihood of reporting any MVPA at 6- and 18-month post-diagnosis and B) either no change or increased MVPA. In Aim 2, pre-diagnosis MVPA was not associated with adaptive immune response or risk of recurrence score incorporating proliferation and tumor size (ROR-PT) in the overall cohort. However, among ER-negative cases, pre-diagnosis MVPA was associated with a lower frequency of adaptive immune response. Although not statistically significant, MVPA was associated with a lower frequency of high ROR-PT in ER-positive cases and a high frequency of high ROR-PT in ER-negative cases.Conclusions: Demographic, social, and clinical correlates of MVPA were identified among breast cancer survivors. Pre-diagnosis MVPA was indicative of MVPA participation at post-diagnosis and was associated with a lower frequency of adaptive immune response among ER-negative cases.
- 일반주제명
- Epidemiology
- 일반주제명
- Biology
- 일반주제명
- Oncology
- 키워드
- Breast cancer
- 키워드
- Health disparity
- 기타저자
- The University of North Carolina at Chapel Hill Epidemiology
- 기본자료저록
- Dissertations Abstracts International. 86-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2024 us c eng d■001000017356940
■00520260202103104
■006m o d
■007cr#unu||||||||
■020 ▼a9798315703532
■035 ▼a(MiAaPQ)AAI31935258
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a614.4
■1001 ▼aKebede, Michael A.
■24510▼aPhysical Activity and Breast Tumor Biology Among Breast Cancer Survivors
■260 ▼a[Sl]▼bThe University of North Carolina at Chapel Hill▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a136 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-11, Section: B.
■500 ▼aAdvisor: Troester, Melissa A.
■5021 ▼aThesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2024.
■520 ▼aBackground: Moderate to vigorous physical activity (MVPA) is associated with improved breast cancer survival, yet few studies have assessed the demographic, social, and clinical factors of MVPA across a diverse group of survivors. Black women report lower MVPA levels, are diagnosed with more aggressive cancers, and have overall higher mortality. Breast cancer outcomes could be attributed to biological markers (e.g., immune response and risk of recurrence score), although the role of MVPA in these pathways is unclear. Understanding patterns and correlates of MVPA in a diverse population of breast cancer survivors may improve recommendations and treatment allocation.Methods: This project leveraged the Carolina Breast Cancer Study Phase 3 (CBCS3; Aim 1: Longitudinal study Naim1=2,994; Aim 2: Cross-sectional study Naim2=1,424). CBCS3 is a population-based study that oversampled black and young women (50 years). This project had two aims: 1) to describe MVPA patterns and their correlates, and 2) to examine associations between pre-diagnosis MVPA and tumor molecular signature overall and stratified by estrogen receptor (ER) status.Results: In Aim 1, 83% of participants who reported MVPA pre-diagnosis experienced a decline at 6-month post-diagnosis. However, a higher proportion (85%) of these participants rebounded their MVPA at 18-month post-diagnosis compared to those who reported no MVPA pre-diagnosis. Demographic, social, and clinical correlates such as income $30K, community-level SES, and chemotherapy were significantly associated with A) higher likelihood of reporting any MVPA at 6- and 18-month post-diagnosis and B) either no change or increased MVPA. In Aim 2, pre-diagnosis MVPA was not associated with adaptive immune response or risk of recurrence score incorporating proliferation and tumor size (ROR-PT) in the overall cohort. However, among ER-negative cases, pre-diagnosis MVPA was associated with a lower frequency of adaptive immune response. Although not statistically significant, MVPA was associated with a lower frequency of high ROR-PT in ER-positive cases and a high frequency of high ROR-PT in ER-negative cases.Conclusions: Demographic, social, and clinical correlates of MVPA were identified among breast cancer survivors. Pre-diagnosis MVPA was indicative of MVPA participation at post-diagnosis and was associated with a lower frequency of adaptive immune response among ER-negative cases.
■590 ▼aSchool code: 0153.
■650 4▼aEpidemiology
■650 4▼aBiology
■650 4▼aOncology
■653 ▼aBreast cancer
■653 ▼aBreast tumor molecular marker
■653 ▼aHealth disparity
■653 ▼aPhysical activity
■653 ▼aEstrogen receptor
■690 ▼a0766
■690 ▼a0992
■690 ▼a0306
■71020▼aThe University of North Carolina at Chapel Hill▼bEpidemiology.
■7730 ▼tDissertations Abstracts International▼g86-11B.
■790 ▼a0153
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17356940▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
