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Neuromodulation Parameters for Non-Invasive Magnetic Stimulation of the Cervicothoracic Spine
Neuromodulation Parameters for Non-Invasive Magnetic Stimulation of the Cervicothoracic Spine
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103155
- ISBN
- 9798286434701
- DDC
- 615.82
- 저자명
- Zhu, Lei.
- 서명/저자
- Neuromodulation Parameters for Non-Invasive Magnetic Stimulation of the Cervicothoracic Spine
- 발행사항
- [Sl] : The University of Iowa, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 121 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Shields, Richard K.
- 학위논문주기
- Thesis (Ph.D.)--The University of Iowa, 2025.
- 초록/해제
- 요약Stroke is a major healthcare challenge and a leading cause of long-term paralysis, with over 80% of survivors experiencing upper limb motor impairment. Researchers are exploring effective strategies to successfully stimulate remaining sensorimotor pathways after stroke, and evidence suggests that noninvasive transcutaneous magnetic spinal stimulation (TMSS) may be a promising option. This thesis investigates TMSS parameters through three studies. The first study focused on determining optimal coil positioning to standardize TMSS protocols. Results showed that the highest motor responses were elicited when the coil was positioned 3 cm lateral to the central spinal column and the coil handle oriented at 45° or 315° to target left- or right-sided muscles, respectively. The second study examined the significant relationship between neural pathway excitability and motor performance. Findings indicated that higher spinal excitability was correlated to faster force production and better task performance but smaller improvements during the task, whereas higher cortical excitability was associated with greater force production, better overall performance, and greater corrections during task execution. The third study investigated the neuromodulatory effects of repetitive TMSS (rTMSS) at 5 Hz, 10 Hz, and 15 Hz, comparing outcomes after 5 and 10 minutes of stimulation. While no significant differences were observed between durations, 5 minutes of 5 Hz rTMSS facilitated corticospinal excitability, whereas 10 Hz and 15 Hz suppressed spinal excitability. These findings suggest TMSS can modulate sensorimotor pathways and support motor recovery. Overall, these studies provide critical insights into TMSS protocols and highlight its promise as a neuromodulation tool in neurorehabilitation.
- 일반주제명
- Physical therapy
- 일반주제명
- Neurosciences
- 키워드
- Stroke
- 기타저자
- The University of Iowa Physical Rehabilitation Science
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202103155
■006m o d
■007cr#unu||||||||
■020 ▼a9798286434701
■035 ▼a(MiAaPQ)AAI31997756
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a615.82
■1001 ▼aZhu, Lei.
■24510▼aNeuromodulation Parameters for Non-Invasive Magnetic Stimulation of the Cervicothoracic Spine
■260 ▼a[Sl]▼bThe University of Iowa▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a121 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Shields, Richard K.
■5021 ▼aThesis (Ph.D.)--The University of Iowa, 2025.
■520 ▼aStroke is a major healthcare challenge and a leading cause of long-term paralysis, with over 80% of survivors experiencing upper limb motor impairment. Researchers are exploring effective strategies to successfully stimulate remaining sensorimotor pathways after stroke, and evidence suggests that noninvasive transcutaneous magnetic spinal stimulation (TMSS) may be a promising option. This thesis investigates TMSS parameters through three studies. The first study focused on determining optimal coil positioning to standardize TMSS protocols. Results showed that the highest motor responses were elicited when the coil was positioned 3 cm lateral to the central spinal column and the coil handle oriented at 45° or 315° to target left- or right-sided muscles, respectively. The second study examined the significant relationship between neural pathway excitability and motor performance. Findings indicated that higher spinal excitability was correlated to faster force production and better task performance but smaller improvements during the task, whereas higher cortical excitability was associated with greater force production, better overall performance, and greater corrections during task execution. The third study investigated the neuromodulatory effects of repetitive TMSS (rTMSS) at 5 Hz, 10 Hz, and 15 Hz, comparing outcomes after 5 and 10 minutes of stimulation. While no significant differences were observed between durations, 5 minutes of 5 Hz rTMSS facilitated corticospinal excitability, whereas 10 Hz and 15 Hz suppressed spinal excitability. These findings suggest TMSS can modulate sensorimotor pathways and support motor recovery. Overall, these studies provide critical insights into TMSS protocols and highlight its promise as a neuromodulation tool in neurorehabilitation.
■590 ▼aSchool code: 0096.
■650 4▼aPhysical therapy
■650 4▼aNeurosciences
■653 ▼aStroke
■653 ▼aNeuromodulatory effects
■653 ▼aTranscutaneous magnetic spinal stimulation
■690 ▼a0382
■690 ▼a0317
■690 ▼a0769
■71020▼aThe University of Iowa▼bPhysical Rehabilitation Science.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0096
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357248▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
