서브메뉴
검색
Understanding Cardiovascular Aging in Women: A Life Course and Reproductive History Perspective
Understanding Cardiovascular Aging in Women: A Life Course and Reproductive History Perspective
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104846
- ISBN
- 9798290970691
- DDC
- 614.4
- 서명/저자
- Understanding Cardiovascular Aging in Women: A Life Course and Reproductive History Perspective
- 발행사항
- [Sl] : University of Pittsburgh, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 176 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: A.
- 주기사항
- Advisor: Catov, Janet M.
- 학위논문주기
- Thesis (Ph.D.)--University of Pittsburgh, 2025.
- 초록/해제
- 요약This dissertation presents analyses of prospective data from the Coronary Artery Risk Development in Young Adults (CARDIA) Study, which captures women's reproductive histories beginning as early as age 18, along with contemporaneous echocardiographic measurements of cardiac structure and function. The overarching objective was to determine whether risk factors related to reproductive history may be unique contributors to cardiovascular aging in women.The first analysis examines whether greater lifetime parity is associated with more adverse change in left ventricular mass and geometry and considers if this association may be due to patterns of central adiposity over time. The second assesses whether various pre-pregnancy echocardiographic measures of left ventricular structure, function, and vascular resistance are associated with subsequent preterm birth outcomes. The third analysis examines the role of self-reported infertility and subsequent left ventricular mass among those who were nulliparous at baseline, with a sub-analysis of women who became parous during the follow-up period.Each manuscript makes a unique contribution to public health significance regarding female cardiovascular health. The first reports that mothers with just one lifetime birth displayed greater change in left ventricular mass that was not accounted for by traditional cardiovascular risk factors, waist circumference patterns, or visceral adiposity. The second demonstrates that women who experienced preterm birth were more likely to have elevated pre-pregnancy left ventricular mass indexed for body surface area. The third highlights self-reported infertility as an independent predictor of greater, more adverse left ventricular mass. More adverse outcomes were consistently observed among women with one lifetime birth and, across all analyses, patterns were further shaped by persistent differences between Black and White women. Women with a single birth may represent a distinct risk group for adverse cardiac remodeling, particularly when considering racial disparities in reproductive exposures. This key finding underscores the importance of considering number of lifetime births, pregnancy complications, and history of infertility as distinct yet interrelated factors that contribute uniquely to female cardiovascular health. Overall, this work highlights a continuum of cardiovascular aging throughout the reproductive life course, demonstrating how subclinical cardiac changes are interconnected with women's reproductive experiences.
- 일반주제명
- Epidemiology
- 일반주제명
- Public health
- 일반주제명
- Womens studies
- 일반주제명
- Obstetrics
- 키워드
- Aging
- 키워드
- Pregnancy
- 키워드
- Women's health
- 기타저자
- University of Pittsburgh Epidemiology
- 기본자료저록
- Dissertations Abstracts International. 87-02A.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2025 us c eng d■001000017359181
■00520260202104846
■006m o d
■007cr#unu||||||||
■020 ▼a9798290970691
■035 ▼a(MiAaPQ)AAI32173738
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a614.4
■1001 ▼aSnyder, Gabrielle G.▼0(orcid)0000-0002-6951-5032
■24510▼aUnderstanding Cardiovascular Aging in Women: A Life Course and Reproductive History Perspective
■260 ▼a[Sl]▼bUniversity of Pittsburgh▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a176 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: A.
■500 ▼aAdvisor: Catov, Janet M.
■5021 ▼aThesis (Ph.D.)--University of Pittsburgh, 2025.
■520 ▼aThis dissertation presents analyses of prospective data from the Coronary Artery Risk Development in Young Adults (CARDIA) Study, which captures women's reproductive histories beginning as early as age 18, along with contemporaneous echocardiographic measurements of cardiac structure and function. The overarching objective was to determine whether risk factors related to reproductive history may be unique contributors to cardiovascular aging in women.The first analysis examines whether greater lifetime parity is associated with more adverse change in left ventricular mass and geometry and considers if this association may be due to patterns of central adiposity over time. The second assesses whether various pre-pregnancy echocardiographic measures of left ventricular structure, function, and vascular resistance are associated with subsequent preterm birth outcomes. The third analysis examines the role of self-reported infertility and subsequent left ventricular mass among those who were nulliparous at baseline, with a sub-analysis of women who became parous during the follow-up period.Each manuscript makes a unique contribution to public health significance regarding female cardiovascular health. The first reports that mothers with just one lifetime birth displayed greater change in left ventricular mass that was not accounted for by traditional cardiovascular risk factors, waist circumference patterns, or visceral adiposity. The second demonstrates that women who experienced preterm birth were more likely to have elevated pre-pregnancy left ventricular mass indexed for body surface area. The third highlights self-reported infertility as an independent predictor of greater, more adverse left ventricular mass. More adverse outcomes were consistently observed among women with one lifetime birth and, across all analyses, patterns were further shaped by persistent differences between Black and White women. Women with a single birth may represent a distinct risk group for adverse cardiac remodeling, particularly when considering racial disparities in reproductive exposures. This key finding underscores the importance of considering number of lifetime births, pregnancy complications, and history of infertility as distinct yet interrelated factors that contribute uniquely to female cardiovascular health. Overall, this work highlights a continuum of cardiovascular aging throughout the reproductive life course, demonstrating how subclinical cardiac changes are interconnected with women's reproductive experiences.
■590 ▼aSchool code: 0178.
■650 4▼aEpidemiology
■650 4▼aPublic health
■650 4▼aWomens studies
■650 4▼aObstetrics
■653 ▼aAging
■653 ▼aCardiovascular aging
■653 ▼aPregnancy
■653 ▼aWomen's health
■653 ▼aReproductive history
■690 ▼a0766
■690 ▼a0573
■690 ▼a0453
■690 ▼a0380
■71020▼aUniversity of Pittsburgh▼bEpidemiology.
■7730 ▼tDissertations Abstracts International▼g87-02A.
■790 ▼a0178
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359181▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
