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Molecular Biomarkers of Subclinical Cardiovascular Disease in the Tobago Health Study and Long Life Family Study
Molecular Biomarkers of Subclinical Cardiovascular Disease in the Tobago Health Study and Long Life Family Study
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104847
- ISBN
- 9798290979885
- DDC
- 614.4
- 저자명
- Katz, Rain.
- 서명/저자
- Molecular Biomarkers of Subclinical Cardiovascular Disease in the Tobago Health Study and Long Life Family Study
- 발행사항
- [Sl] : University of Pittsburgh, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 174 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Kuipers, Allison.
- 학위논문주기
- Thesis (Ph.D.)--University of Pittsburgh, 2025.
- 초록/해제
- 요약Recent advances in molecular biology and statistical techniques have allowed researchers to study the role of biomarkers and biological processes in the development of cardiovascular disease (CVD) throughout life. Subclinical measures of CVD-asymptomatic markers that are highly predictive of future CVD morbidity and mortality-allow researchers and clinicians to assess the progression from cardiovascular health to disease. The overall purpose of this dissertation is to identify molecular biomarkers and processes that are related to subclinical CVD in unique study populations-the Tobago Health Study and the Long Life Family Study.The first aim describes a large-scale protein assay carried out in a Tobagonian population, with the goal of identifying novel relationships between blood protein concentrations and subclinical CVD. We successfully identified 17 associations between protein markers and subclinical CVD measures, 10 of which are novel. The second aim, also in Tobagonians, sought to identify relationships between exposures to trace elements, DNA methylation at selected sites in the genome, and subclinical CVD; and investigate whether DNA methylation may mediate the relationship between these exposures and outcomes. Although trace elements were related to both subclinical CVD and DNA methylation, and DNA methylation was associated with subclinical CVD, a meaningful mediation effect was not observed. The third aim describes a transcriptomic study of CVD traits in the Long Life Family Study; a cohort study of families which display exceptional longevity. A total of 297 RNA products were identified that are associated with systolic and/or diastolic blood pressure, as well as hundreds of biological pathways that may be related to cardiovascular health and disease in this study population.Overall, this dissertation contributes to a growing body of research describing the role of molecular biomarkers in CVD, including by identifying novel markers and associations. Understanding the molecular biology of cardiovascular disease will improve clinicians' and researchers' ability to identify individuals at high risk for future disease and guide public health interventions to prevent and treat the leading cause of death worldwide.
- 일반주제명
- Epidemiology
- 일반주제명
- Public health
- 일반주제명
- Molecular biology
- 키워드
- DNA
- 기타저자
- University of Pittsburgh Epidemiology
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798290979885
■035 ▼a(MiAaPQ)AAI32173864
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a614.4
■1001 ▼aKatz, Rain.
■24510▼aMolecular Biomarkers of Subclinical Cardiovascular Disease in the Tobago Health Study and Long Life Family Study
■260 ▼a[Sl]▼bUniversity of Pittsburgh▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a174 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Kuipers, Allison.
■5021 ▼aThesis (Ph.D.)--University of Pittsburgh, 2025.
■520 ▼aRecent advances in molecular biology and statistical techniques have allowed researchers to study the role of biomarkers and biological processes in the development of cardiovascular disease (CVD) throughout life. Subclinical measures of CVD-asymptomatic markers that are highly predictive of future CVD morbidity and mortality-allow researchers and clinicians to assess the progression from cardiovascular health to disease. The overall purpose of this dissertation is to identify molecular biomarkers and processes that are related to subclinical CVD in unique study populations-the Tobago Health Study and the Long Life Family Study.The first aim describes a large-scale protein assay carried out in a Tobagonian population, with the goal of identifying novel relationships between blood protein concentrations and subclinical CVD. We successfully identified 17 associations between protein markers and subclinical CVD measures, 10 of which are novel. The second aim, also in Tobagonians, sought to identify relationships between exposures to trace elements, DNA methylation at selected sites in the genome, and subclinical CVD; and investigate whether DNA methylation may mediate the relationship between these exposures and outcomes. Although trace elements were related to both subclinical CVD and DNA methylation, and DNA methylation was associated with subclinical CVD, a meaningful mediation effect was not observed. The third aim describes a transcriptomic study of CVD traits in the Long Life Family Study; a cohort study of families which display exceptional longevity. A total of 297 RNA products were identified that are associated with systolic and/or diastolic blood pressure, as well as hundreds of biological pathways that may be related to cardiovascular health and disease in this study population.Overall, this dissertation contributes to a growing body of research describing the role of molecular biomarkers in CVD, including by identifying novel markers and associations. Understanding the molecular biology of cardiovascular disease will improve clinicians' and researchers' ability to identify individuals at high risk for future disease and guide public health interventions to prevent and treat the leading cause of death worldwide.
■590 ▼aSchool code: 0178.
■650 4▼aEpidemiology
■650 4▼aPublic health
■650 4▼aMolecular biology
■653 ▼aCardiovascular disease
■653 ▼aDNA
■653 ▼aCardiovascular health
■653 ▼aTobagonian population
■690 ▼a0766
■690 ▼a0307
■690 ▼a0573
■71020▼aUniversity of Pittsburgh▼bEpidemiology.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0178
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359189▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
