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Big Insights From a Small Rheometer: Viscoelastic Measurements of Biopolymeric Fluids
Big Insights From a Small Rheometer: Viscoelastic Measurements of Biopolymeric Fluids
Detailed Information
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104850
- ISBN
- 9798288815393
- DDC
- 617
- 저자명
- Shih, Audrey.
- 서명/저자
- Big Insights From a Small Rheometer: Viscoelastic Measurements of Biopolymeric Fluids
- 발행사항
- [Sl] : Stanford University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 106 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Fuller, Gerald.
- 학위논문주기
- Thesis (Ph.D.)--Stanford University, 2025.
- 초록/해제
- 요약The mechanical properties of complex biological fluids play a key role in clinical treatments and tissue engineering. This work presents the development and application of a custom magnetic stress rheometer (MSR) platform to characterize viscoelastic fluids in two biomedical contexts: naturally occurring biological materials and biofabricated materials. In the first application, the MSR was used to measure the rheological behavior of abscess fluids, enabling flow predictions during drainage and offering insights to improve clinical outcomes. The creep response of these heterogeneous fluids was described by a five-element viscoelastic model, and zero-shear viscosity was found to be a practical and sufficient metric for predicting drainage behavior. The wide range of observed viscoelastic parameters demonstrates the need for point-of-care rheological assessments to guide catheter selection and personalize treatment plans. In the second application, the MSR was adapted with a boundary layer setup to monitor biomaterial ink crosslinking in situ during diffusion-mediated gelation in embedded 3D bioprinting. This approach enabled mechanical measurements throughout the crosslinking process, revealing how viscoelasticity evolves with geometric and reaction parameters. These insights provide a predictive framework for tuning ink formulations and bioprinting protocols to balance structural integrity with cell viability. Collectively, these studies demonstrate the versatility of the MSR platform in capturing time-dependent mechanics across diverse biomedical materials and advancing applications in both clinical and regenerative medicine.
- 일반주제명
- Tissue engineering
- 일반주제명
- Etiology
- 일반주제명
- Patients
- 일반주제명
- Polymers
- 일반주제명
- Viscosity
- 일반주제명
- Collagen
- 일반주제명
- Success
- 일반주제명
- Rheology
- 일반주제명
- Disease
- 일반주제명
- Mortality
- 일반주제명
- Catheters
- 일반주제명
- Magnetic fields
- 일반주제명
- 3-D printers
- 일반주제명
- Abscesses
- 일반주제명
- Fluids
- 일반주제명
- Biomedical materials
- 일반주제명
- Viscoelasticity
- 일반주제명
- Hospital costs
- 일반주제명
- Hydrogels
- 일반주제명
- Bioengineering
- 일반주제명
- Fluid mechanics
- 일반주제명
- Chemical engineering
- 키워드
- Viscoelasticity
- 기타저자
- Stanford University.
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■007cr#unu||||||||
■020 ▼a9798288815393
■035 ▼a(MiAaPQ)AAI32200949
■035 ▼a(MiAaPQ)Stanfordgw114nv9901
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a617
■1001 ▼aShih, Audrey.
■24510▼aBig Insights From a Small Rheometer: Viscoelastic Measurements of Biopolymeric Fluids
■260 ▼a[Sl]▼bStanford University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a106 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Fuller, Gerald.
■5021 ▼aThesis (Ph.D.)--Stanford University, 2025.
■520 ▼aThe mechanical properties of complex biological fluids play a key role in clinical treatments and tissue engineering. This work presents the development and application of a custom magnetic stress rheometer (MSR) platform to characterize viscoelastic fluids in two biomedical contexts: naturally occurring biological materials and biofabricated materials. In the first application, the MSR was used to measure the rheological behavior of abscess fluids, enabling flow predictions during drainage and offering insights to improve clinical outcomes. The creep response of these heterogeneous fluids was described by a five-element viscoelastic model, and zero-shear viscosity was found to be a practical and sufficient metric for predicting drainage behavior. The wide range of observed viscoelastic parameters demonstrates the need for point-of-care rheological assessments to guide catheter selection and personalize treatment plans. In the second application, the MSR was adapted with a boundary layer setup to monitor biomaterial ink crosslinking in situ during diffusion-mediated gelation in embedded 3D bioprinting. This approach enabled mechanical measurements throughout the crosslinking process, revealing how viscoelasticity evolves with geometric and reaction parameters. These insights provide a predictive framework for tuning ink formulations and bioprinting protocols to balance structural integrity with cell viability. Collectively, these studies demonstrate the versatility of the MSR platform in capturing time-dependent mechanics across diverse biomedical materials and advancing applications in both clinical and regenerative medicine.
■590 ▼aSchool code: 0212.
■650 4▼aTissue engineering
■650 4▼aEtiology
■650 4▼aPatients
■650 4▼aPolymers
■650 4▼aViscosity
■650 4▼aCollagen
■650 4▼aSuccess
■650 4▼aRheology
■650 4▼aDisease
■650 4▼aMortality
■650 4▼aCatheters
■650 4▼aMagnetic fields
■650 4▼a3-D printers
■650 4▼aAbscesses
■650 4▼aFluids
■650 4▼aBiomedical materials
■650 4▼aViscoelasticity
■650 4▼aHospital costs
■650 4▼aHydrogels
■650 4▼aBioengineering
■650 4▼aFluid mechanics
■650 4▼aChemical engineering
■653 ▼aMagnetic stress rheometer
■653 ▼aRheological assessments
■653 ▼aViscoelasticity
■690 ▼a0202
■690 ▼a0542
■690 ▼a0204
■71020▼aStanford University.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0212
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359212▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
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