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Big Insights From a Small Rheometer: Viscoelastic Measurements of Biopolymeric Fluids
Big Insights From a Small Rheometer: Viscoelastic Measurements of Biopolymeric Fluids
Big Insights From a Small Rheometer: Viscoelastic Measurements of Biopolymeric Fluids

Detailed Information

자료유형  
 학위논문 서양
최종처리일시  
20260202104850
ISBN  
9798288815393
DDC  
617
저자명  
Shih, Audrey.
서명/저자  
Big Insights From a Small Rheometer: Viscoelastic Measurements of Biopolymeric Fluids
발행사항  
[Sl] : Stanford University, 2025
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2025
형태사항  
106 p
주기사항  
Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
주기사항  
Advisor: Fuller, Gerald.
학위논문주기  
Thesis (Ph.D.)--Stanford University, 2025.
초록/해제  
요약The mechanical properties of complex biological fluids play a key role in clinical treatments and tissue engineering. This work presents the development and application of a custom magnetic stress rheometer (MSR) platform to characterize viscoelastic fluids in two biomedical contexts: naturally occurring biological materials and biofabricated materials. In the first application, the MSR was used to measure the rheological behavior of abscess fluids, enabling flow predictions during drainage and offering insights to improve clinical outcomes. The creep response of these heterogeneous fluids was described by a five-element viscoelastic model, and zero-shear viscosity was found to be a practical and sufficient metric for predicting drainage behavior. The wide range of observed viscoelastic parameters demonstrates the need for point-of-care rheological assessments to guide catheter selection and personalize treatment plans. In the second application, the MSR was adapted with a boundary layer setup to monitor biomaterial ink crosslinking in situ during diffusion-mediated gelation in embedded 3D bioprinting. This approach enabled mechanical measurements throughout the crosslinking process, revealing how viscoelasticity evolves with geometric and reaction parameters. These insights provide a predictive framework for tuning ink formulations and bioprinting protocols to balance structural integrity with cell viability. Collectively, these studies demonstrate the versatility of the MSR platform in capturing time-dependent mechanics across diverse biomedical materials and advancing applications in both clinical and regenerative medicine.
일반주제명  
Tissue engineering
일반주제명  
Etiology
일반주제명  
Patients
일반주제명  
Polymers
일반주제명  
Viscosity
일반주제명  
Collagen
일반주제명  
Success
일반주제명  
Rheology
일반주제명  
Disease
일반주제명  
Mortality
일반주제명  
Catheters
일반주제명  
Magnetic fields
일반주제명  
3-D printers
일반주제명  
Abscesses
일반주제명  
Fluids
일반주제명  
Biomedical materials
일반주제명  
Viscoelasticity
일반주제명  
Hospital costs
일반주제명  
Hydrogels
일반주제명  
Bioengineering
일반주제명  
Fluid mechanics
일반주제명  
Chemical engineering
키워드  
Magnetic stress rheometer
키워드  
Rheological assessments
키워드  
Viscoelasticity
기타저자  
Stanford University.
기본자료저록  
Dissertations Abstracts International. 87-02B.
전자적 위치 및 접속  
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MARC

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■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a617
■1001  ▼aShih,  Audrey.
■24510▼aBig  Insights  From  a  Small  Rheometer:  Viscoelastic  Measurements  of  Biopolymeric  Fluids
■260    ▼a[Sl]▼bStanford  University▼c2025
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2025
■300    ▼a106  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  87-02,  Section:  B.
■500    ▼aAdvisor:  Fuller,  Gerald.
■5021  ▼aThesis  (Ph.D.)--Stanford  University,  2025.
■520    ▼aThe  mechanical  properties  of  complex  biological  fluids  play  a  key  role  in  clinical  treatments  and  tissue  engineering.  This  work  presents  the  development  and  application  of  a  custom  magnetic  stress  rheometer  (MSR)  platform  to  characterize  viscoelastic  fluids  in  two  biomedical  contexts:  naturally  occurring  biological  materials  and  biofabricated  materials.  In  the  first  application,  the  MSR  was  used  to  measure  the  rheological  behavior  of  abscess  fluids,  enabling  flow  predictions  during  drainage  and  offering  insights  to  improve  clinical  outcomes.  The  creep  response  of  these  heterogeneous  fluids  was  described  by  a  five-element  viscoelastic  model,  and  zero-shear  viscosity  was  found  to  be  a  practical  and  sufficient  metric  for  predicting  drainage  behavior.  The  wide  range  of  observed  viscoelastic  parameters  demonstrates  the  need  for  point-of-care  rheological  assessments  to  guide  catheter  selection  and  personalize  treatment  plans.  In  the  second  application,  the  MSR  was  adapted  with  a  boundary  layer  setup  to  monitor  biomaterial  ink  crosslinking  in  situ  during  diffusion-mediated  gelation  in  embedded  3D  bioprinting.  This  approach  enabled  mechanical  measurements  throughout  the  crosslinking  process,  revealing  how  viscoelasticity  evolves  with  geometric  and  reaction  parameters.  These  insights  provide  a  predictive  framework  for  tuning  ink  formulations  and  bioprinting  protocols  to  balance  structural  integrity  with  cell  viability.  Collectively,  these  studies  demonstrate  the  versatility  of  the  MSR  platform  in  capturing  time-dependent  mechanics  across  diverse  biomedical  materials  and  advancing  applications  in  both  clinical  and  regenerative  medicine.
■590    ▼aSchool  code:  0212.
■650  4▼aTissue  engineering
■650  4▼aEtiology
■650  4▼aPatients
■650  4▼aPolymers
■650  4▼aViscosity
■650  4▼aCollagen
■650  4▼aSuccess
■650  4▼aRheology
■650  4▼aDisease
■650  4▼aMortality
■650  4▼aCatheters
■650  4▼aMagnetic  fields
■650  4▼a3-D  printers
■650  4▼aAbscesses
■650  4▼aFluids
■650  4▼aBiomedical  materials
■650  4▼aViscoelasticity
■650  4▼aHospital  costs
■650  4▼aHydrogels
■650  4▼aBioengineering
■650  4▼aFluid  mechanics
■650  4▼aChemical  engineering
■653    ▼aMagnetic  stress  rheometer
■653    ▼aRheological  assessments
■653    ▼aViscoelasticity
■690    ▼a0202
■690    ▼a0542
■690    ▼a0204
■71020▼aStanford  University.
■7730  ▼tDissertations  Abstracts  International▼g87-02B.
■790    ▼a0212
■791    ▼aPh.D.
■792    ▼a2025
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359212▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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