서브메뉴
검색
Gait Signatures: Data-Driven Discovery of Individual-Specific Neuromechanical Dynamics
Gait Signatures: Data-Driven Discovery of Individual-Specific Neuromechanical Dynamics
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105549
- ISBN
- 9798265400178
- DDC
- 612.8
- 서명/저자
- Gait Signatures: Data-Driven Discovery of Individual-Specific Neuromechanical Dynamics
- 발행사항
- [Sl] : Georgia Institute of Technology, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 228 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-05, Section: B.
- 주기사항
- Advisor: Ting, Lena.
- 학위논문주기
- Thesis (Ph.D.)--Georgia Institute of Technology, 2024.
- 초록/해제
- 요약Human gait is important because it is fundamental to the execution of daily activities which impacts quality of life. Notably, changes to individuals' gait patterns can indicate underlying health issues such as musculoskeletal and neurological disorders, underscoring the importance of gait analysis towards rehabilitation following disease, injury and surgery. However, standard methods often focus on discrete gait variables, neglecting continuous data and complex inter-limb and inter-joint spatiotemporal dependencies that underly gait and impairment. A comprehensive approach is necessary to analyze gait patterns, diagnose conditions accurately, prescribe treatments, develop tailored rehabilitation strategies and monitor progress effectively.This thesis introduces a novel, data-driven approach to model the dynamics of human gait, effectively capturing the complex spatiotemporal dependencies between individuals' joint angles, arising from joint neural and biomechanical constraints. Individual-specific representations of gait dynamics, termed "gait signatures", offer a holistic way to identify and quantify individual-specific differences in gait in both health and disease. I use continuous gait kinematics from multiple individuals to train a single recurrent neural network (RNN) to predict the time evolution of multi-joint gait coordination, thereby capturing the underlying dynamics of human gait. By recapitulating the gait behaviors of multiple individuals into common low-dimensional basis functions, this approach facilitates holistic comparison of gait dynamics across different individuals and cohorts in a shared gait space. This method is particularly valuable for modeling complex gait deviations, including those seen in individuals with neurological disorders, as it eliminates the challenging task of estimating physiological constraints like neural control.In a series of studies, I demonstrate that highly individualized gait dynamics (i.e. gait signatures) are conserved across walking speed for both able-bodied (AB) adults and stroke survivors during treadmill walking. Notably, AB gait signatures show predictable, linear changes across a wide range of speeds. These gait signatures, comprising of biomechanically interpretable subcomponents, can be manipulated to understand their relationship with observed joint coordination patterns. Additionally, using the RNN gait dynamics model, I demonstrate its ability to predict the time evolution of multi-joint coordination from an initial posture. Finally, I utilized the gait signatures framework to track and quantify clinically meaningful changes in stroke survivors' gait signatures through two longitudinal gait interventions (Fast and Fast Functional Electrical Stimulation). These findings underscore the potential of gait signatures for evaluating and interpreting treatment induced changes in gait in a holistic manner.This work demonstrates promising clinical applications in precision medicine. Gait signatures offer an objective, reliable and repeatable method to differentiate and analyze individuals' unique dynamics regardless of walking speed. They can predict the potential response to gait interventions and perturbations, facilitating the development of personalized strategies to improve gait while reducing time and participant burden.
- 일반주제명
- Brain research
- 일반주제명
- Tendons
- 일반주제명
- Electromyography
- 일반주제명
- Dynamical systems
- 일반주제명
- Ataxia
- 일반주제명
- Human subjects
- 일반주제명
- Gait
- 일반주제명
- Stroke
- 일반주제명
- Musculoskeletal system
- 일반주제명
- Neurological disorders
- 일반주제명
- Neural networks
- 일반주제명
- Support vector machines
- 일반주제명
- Kinetics
- 일반주제명
- Nervous system
- 일반주제명
- Muscle function
- 일반주제명
- Posture
- 일반주제명
- Biomechanics
- 일반주제명
- Kinesiology
- 일반주제명
- Computer science
- 일반주제명
- Mathematics
- 일반주제명
- Medicine
- 일반주제명
- Morphology
- 일반주제명
- Neurosciences
- 기본자료저록
- Dissertations Abstracts International. 87-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2024 us c eng d■001000017360577
■00520260202105549
■006m o d
■007cr#unu||||||||
■020 ▼a9798265400178
■035 ▼a(MiAaPQ)AAI32315671
■035 ▼a(MiAaPQ)GeorgiaTech75674
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a612.8
■1001 ▼aWinner, Taniel S.
■24510▼aGait Signatures: Data-Driven Discovery of Individual-Specific Neuromechanical Dynamics
■260 ▼a[Sl]▼bGeorgia Institute of Technology▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a228 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-05, Section: B.
■500 ▼aAdvisor: Ting, Lena.
■5021 ▼aThesis (Ph.D.)--Georgia Institute of Technology, 2024.
■520 ▼aHuman gait is important because it is fundamental to the execution of daily activities which impacts quality of life. Notably, changes to individuals' gait patterns can indicate underlying health issues such as musculoskeletal and neurological disorders, underscoring the importance of gait analysis towards rehabilitation following disease, injury and surgery. However, standard methods often focus on discrete gait variables, neglecting continuous data and complex inter-limb and inter-joint spatiotemporal dependencies that underly gait and impairment. A comprehensive approach is necessary to analyze gait patterns, diagnose conditions accurately, prescribe treatments, develop tailored rehabilitation strategies and monitor progress effectively.This thesis introduces a novel, data-driven approach to model the dynamics of human gait, effectively capturing the complex spatiotemporal dependencies between individuals' joint angles, arising from joint neural and biomechanical constraints. Individual-specific representations of gait dynamics, termed "gait signatures", offer a holistic way to identify and quantify individual-specific differences in gait in both health and disease. I use continuous gait kinematics from multiple individuals to train a single recurrent neural network (RNN) to predict the time evolution of multi-joint gait coordination, thereby capturing the underlying dynamics of human gait. By recapitulating the gait behaviors of multiple individuals into common low-dimensional basis functions, this approach facilitates holistic comparison of gait dynamics across different individuals and cohorts in a shared gait space. This method is particularly valuable for modeling complex gait deviations, including those seen in individuals with neurological disorders, as it eliminates the challenging task of estimating physiological constraints like neural control.In a series of studies, I demonstrate that highly individualized gait dynamics (i.e. gait signatures) are conserved across walking speed for both able-bodied (AB) adults and stroke survivors during treadmill walking. Notably, AB gait signatures show predictable, linear changes across a wide range of speeds. These gait signatures, comprising of biomechanically interpretable subcomponents, can be manipulated to understand their relationship with observed joint coordination patterns. Additionally, using the RNN gait dynamics model, I demonstrate its ability to predict the time evolution of multi-joint coordination from an initial posture. Finally, I utilized the gait signatures framework to track and quantify clinically meaningful changes in stroke survivors' gait signatures through two longitudinal gait interventions (Fast and Fast Functional Electrical Stimulation). These findings underscore the potential of gait signatures for evaluating and interpreting treatment induced changes in gait in a holistic manner.This work demonstrates promising clinical applications in precision medicine. Gait signatures offer an objective, reliable and repeatable method to differentiate and analyze individuals' unique dynamics regardless of walking speed. They can predict the potential response to gait interventions and perturbations, facilitating the development of personalized strategies to improve gait while reducing time and participant burden.
■590 ▼aSchool code: 0078.
■650 4▼aBrain research
■650 4▼aTendons
■650 4▼aElectromyography
■650 4▼aDynamical systems
■650 4▼aAtaxia
■650 4▼aHuman subjects
■650 4▼aGait
■650 4▼aStroke
■650 4▼aPartial differential equations
■650 4▼aMusculoskeletal system
■650 4▼aNeurological disorders
■650 4▼aNeural networks
■650 4▼aSupport vector machines
■650 4▼aKinetics
■650 4▼aNervous system
■650 4▼aMuscle function
■650 4▼aPosture
■650 4▼aBiomechanics
■650 4▼aKinesiology
■650 4▼aComputer science
■650 4▼aMathematics
■650 4▼aMedicine
■650 4▼aMorphology
■650 4▼aNeurosciences
■690 ▼a0648
■690 ▼a0575
■690 ▼a0800
■690 ▼a0984
■690 ▼a0405
■690 ▼a0564
■690 ▼a0287
■690 ▼a0317
■71020▼aGeorgia Institute of Technology.
■7730 ▼tDissertations Abstracts International▼g87-05B.
■790 ▼a0078
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17360577▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.


