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Effect of Time-Restricted Feeding in High Fat Diet-Induced Obesity: Focusing on Age and Sex Differences in Metabolic Responses and Adipose Tissue Metabolism
Effect of Time-Restricted Feeding in High Fat Diet-Induced Obesity: Focusing on Age and Sex Differences in Metabolic Responses and Adipose Tissue Metabolism
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202102946
- ISBN
- 9798293870288
- DDC
- 641
- 서명/저자
- Effect of Time-Restricted Feeding in High Fat Diet-Induced Obesity: Focusing on Age and Sex Differences in Metabolic Responses and Adipose Tissue Metabolism
- 발행사항
- [Sl] : University of Minnesota, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 170 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Advisor: Chen, Xiaoli.
- 학위논문주기
- Thesis (Ph.D.)--University of Minnesota, 2024.
- 초록/해제
- 요약Obesity and aging are typically accompanied by significant metabolic dysregulation and chronic low-grade inflammation in adipose tissue which plays a critical role in the regulation of energy metabolism. Understanding how time-restricted feeding (TRF) impacts the regulation of adipose tissue metabolism and function within an obese model is crucial to understand if TRF is beneficial in combatting obesity. My research attempts to understand the effects of TRF in high-fat diet (HFD) induced obesity, focusing on age and sex differences in metabolic responses and adipose tissue metabolism. In the first project, we demonstrated TRF is effective for weight loss in HFD-induced obese male mice. TRF restores adipogenesis impaired by HFD and increases lipid storage capacity in white adipose tissues. Additionally, TRF has a depot-dependent effect on lipid metabolism, restoring the ATP-consuming futile cycle of lipogenesis and lipolysis impaired by HFD in epididymal adipose tissue. In the second project, we focused on aged female mice and saw TRF increased energy expenditure and activated the futile lipid cycle in inguinal and gonadal adipose tissue, with increased fatty acid utilization during the light cycle. This adaptation promotes energy expenditure and reduces HFD-induced weight gain. In the third project, we examined the effects of HFD and TRF on extracellular (EV) characteristics, with variations observed between middle-aged and aged female mice. TRF reversed HFD-induced changes in EV proteins involved in metabolism and immune system pathways, suggesting its potential therapeutic relevance in mitigating metabolic and immune system dysregulation. In summary, my doctoral research reveals TRF mediates physiological responses to dietary interventions, such as a HFD, highlighting its potential as a therapeutic strategy for improving metabolic health in obese mice.
- 일반주제명
- Nutrition
- 일반주제명
- Biochemistry
- 일반주제명
- Cellular biology
- 일반주제명
- Biomedical engineering
- 키워드
- Adipose tissue
- 키워드
- Diabetes
- 키워드
- Futile cycling
- 키워드
- High-fat diet
- 키워드
- Obesity
- 기타저자
- University of Minnesota Nutrition
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■007cr#unu||||||||
■020 ▼a9798293870288
■035 ▼a(MiAaPQ)AAI31555866
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a641
■1001 ▼aBushman, Theresa.
■24510▼aEffect of Time-Restricted Feeding in High Fat Diet-Induced Obesity: Focusing on Age and Sex Differences in Metabolic Responses and Adipose Tissue Metabolism
■260 ▼a[Sl]▼bUniversity of Minnesota▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a170 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aAdvisor: Chen, Xiaoli.
■5021 ▼aThesis (Ph.D.)--University of Minnesota, 2024.
■520 ▼aObesity and aging are typically accompanied by significant metabolic dysregulation and chronic low-grade inflammation in adipose tissue which plays a critical role in the regulation of energy metabolism. Understanding how time-restricted feeding (TRF) impacts the regulation of adipose tissue metabolism and function within an obese model is crucial to understand if TRF is beneficial in combatting obesity. My research attempts to understand the effects of TRF in high-fat diet (HFD) induced obesity, focusing on age and sex differences in metabolic responses and adipose tissue metabolism. In the first project, we demonstrated TRF is effective for weight loss in HFD-induced obese male mice. TRF restores adipogenesis impaired by HFD and increases lipid storage capacity in white adipose tissues. Additionally, TRF has a depot-dependent effect on lipid metabolism, restoring the ATP-consuming futile cycle of lipogenesis and lipolysis impaired by HFD in epididymal adipose tissue. In the second project, we focused on aged female mice and saw TRF increased energy expenditure and activated the futile lipid cycle in inguinal and gonadal adipose tissue, with increased fatty acid utilization during the light cycle. This adaptation promotes energy expenditure and reduces HFD-induced weight gain. In the third project, we examined the effects of HFD and TRF on extracellular (EV) characteristics, with variations observed between middle-aged and aged female mice. TRF reversed HFD-induced changes in EV proteins involved in metabolism and immune system pathways, suggesting its potential therapeutic relevance in mitigating metabolic and immune system dysregulation. In summary, my doctoral research reveals TRF mediates physiological responses to dietary interventions, such as a HFD, highlighting its potential as a therapeutic strategy for improving metabolic health in obese mice.
■590 ▼aSchool code: 0130.
■650 4▼aNutrition
■650 4▼aBiochemistry
■650 4▼aCellular biology
■650 4▼aBiomedical engineering
■653 ▼aAdipose tissue
■653 ▼aDiabetes
■653 ▼aExtracellular vesicles
■653 ▼aFutile cycling
■653 ▼aHigh-fat diet
■653 ▼aObesity
■690 ▼a0570
■690 ▼a0487
■690 ▼a0379
■690 ▼a0541
■71020▼aUniversity of Minnesota▼bNutrition.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0130
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17356534▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
