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Target Trial Framework to Evaluate Post-Surgical Discharge Opioid Dosing Strategies on Opioid Use Disorder and Changes in Kidney Function
Target Trial Framework to Evaluate Post-Surgical Discharge Opioid Dosing Strategies on Opioid Use Disorder and Changes in Kidney Function
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202102947
- ISBN
- 9798293861477
- DDC
- 615
- 서명/저자
- Target Trial Framework to Evaluate Post-Surgical Discharge Opioid Dosing Strategies on Opioid Use Disorder and Changes in Kidney Function
- 발행사항
- [Sl] : University of Minnesota, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 193 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Advisor: St. Peter, Wendy.
- 학위논문주기
- Thesis (Ph.D.)--University of Minnesota, 2024.
- 초록/해제
- 요약Growing evidence shows that opioids have been over-prescribed for patients returning home after surgery in the U.S. Currently there are no consensus guidelines on optimal post-surgical opioid dosing at discharge for pain control following various surgeries. Some observational studies suggest that opioid use is associated with reduced kidney function, highlighting the need to investigate the association between opioid prescription post-surgery and kidney dysfunction after discharge. The overarching goal of this dissertation is to evaluate opioid dosing strategies in a post-surgical setting and subsequent opioid use disorder (OUD) and changes in kidney function. The objective of this dissertation research is using real-world data to 1) Compare the impact of 2016 CDC opioid guideline and 2018 Minnesota opioid guideline on reducing high total morphine milligram equivalents (MME) prescribing rate at post-surgical discharge; 2) Evaluate the association between high/low total MME and the risk for developing opioid use disorder for opioid naive adult patients; and 3) Evaluate the effects of high versus low total MME prescribed at post-surgical discharge on change in kidney function over time after surgery in one year.
- 일반주제명
- Pharmacology
- 일반주제명
- Epidemiology
- 일반주제명
- Health sciences
- 일반주제명
- Physiology
- 일반주제명
- Surgery
- 키워드
- Opioid dosing
- 키워드
- Real-world data
- 기타저자
- University of Minnesota Social and Administrative Pharmacy
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a615
■1001 ▼aHsu, Yu-Chia Sam.
■24510▼aTarget Trial Framework to Evaluate Post-Surgical Discharge Opioid Dosing Strategies on Opioid Use Disorder and Changes in Kidney Function
■260 ▼a[Sl]▼bUniversity of Minnesota▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a193 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aAdvisor: St. Peter, Wendy.
■5021 ▼aThesis (Ph.D.)--University of Minnesota, 2024.
■520 ▼aGrowing evidence shows that opioids have been over-prescribed for patients returning home after surgery in the U.S. Currently there are no consensus guidelines on optimal post-surgical opioid dosing at discharge for pain control following various surgeries. Some observational studies suggest that opioid use is associated with reduced kidney function, highlighting the need to investigate the association between opioid prescription post-surgery and kidney dysfunction after discharge. The overarching goal of this dissertation is to evaluate opioid dosing strategies in a post-surgical setting and subsequent opioid use disorder (OUD) and changes in kidney function. The objective of this dissertation research is using real-world data to 1) Compare the impact of 2016 CDC opioid guideline and 2018 Minnesota opioid guideline on reducing high total morphine milligram equivalents (MME) prescribing rate at post-surgical discharge; 2) Evaluate the association between high/low total MME and the risk for developing opioid use disorder for opioid naive adult patients; and 3) Evaluate the effects of high versus low total MME prescribed at post-surgical discharge on change in kidney function over time after surgery in one year.
■590 ▼aSchool code: 0130.
■650 4▼aPharmacology
■650 4▼aEpidemiology
■650 4▼aHealth sciences
■650 4▼aPhysiology
■650 4▼aSurgery
■653 ▼aKidney dysfunction
■653 ▼aOpioid dosing
■653 ▼aOpioid use disorder
■653 ▼aPost-surgical discharge
■653 ▼aReal-world data
■653 ▼aTarget trial framework
■690 ▼a0419
■690 ▼a0766
■690 ▼a0566
■690 ▼a0576
■690 ▼a0719
■71020▼aUniversity of Minnesota▼bSocial and Administrative Pharmacy.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0130
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17356538▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
