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C-C Bond Formation Realized by Amidyl-Radical-Mediated Chain Reactions
C-C Bond Formation Realized by Amidyl-Radical-Mediated Chain Reactions
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103116
- ISBN
- 9798315705246
- DDC
- 540
- 서명/저자
- C-C Bond Formation Realized by Amidyl-Radical-Mediated Chain Reactions
- 발행사항
- [Sl] : The University of North Carolina at Chapel Hill, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 271 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
- 주기사항
- Advisor: Alexanian, Erik J.
- 학위논문주기
- Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2025.
- 초록/해제
- 요약I.X-H Functionalization as a Means for Achieving C-C Bond FormationAn overview of the benefits and challenges related to site-selective, intermolecular C(sp3)-H and carboxylic acid O-H functionalizations are discussed, particularly as they pertain to enabling C-C bond formation.II.Strategic Introduction of Carbon Fragments Onto Building Blocks and Late-Stage MoleculesThe development of an amidyl-radical-mediated chain reaction to convert aliphatic C(sp3)-H bonds into a variety of C-C bonds is discussed. The methods disclosed include (a) C-H functionalizations of tertiary alkylamines and (b) α-heteroatom C-H thioetherification followed by alkylation with an organometallic species.III. Decarboxylative Homologation Using a Radical-Polar Conjunctive Reagent The development of one-carbon homologation of aliphatic carboxylic acids is discussed. Particular attention is paid to the iterative design of a two-carbon SOMOphile that was critical to achieving the desired synthon for the overall transformation.IV.Rapid Access to Α-Ketoesters via C-H and Decarboxylative Pyruvylation Alpha-ketoesters are regarded as highly diversifiable intermediates in organic synthesis, with numerous applications ranging from unnatural amino acid construction to heterocycle formation. A late-stage approach to installing these functional handles onto C(sp3)-H and carboxylic acid-containing molecules is discussed.
- 일반주제명
- Chemistry
- 일반주제명
- Organic chemistry
- 기타저자
- The University of North Carolina at Chapel Hill Chemistry
- 기본자료저록
- Dissertations Abstracts International. 86-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
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■020 ▼a9798315705246
■035 ▼a(MiAaPQ)AAI31937135
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a540
■1001 ▼aGruhin, Jonathan Nelson.
■24510▼aC-C Bond Formation Realized by Amidyl-Radical-Mediated Chain Reactions
■260 ▼a[Sl]▼bThe University of North Carolina at Chapel Hill▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a271 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-11, Section: B.
■500 ▼aAdvisor: Alexanian, Erik J.
■5021 ▼aThesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2025.
■520 ▼aI.X-H Functionalization as a Means for Achieving C-C Bond FormationAn overview of the benefits and challenges related to site-selective, intermolecular C(sp3)-H and carboxylic acid O-H functionalizations are discussed, particularly as they pertain to enabling C-C bond formation.II.Strategic Introduction of Carbon Fragments Onto Building Blocks and Late-Stage MoleculesThe development of an amidyl-radical-mediated chain reaction to convert aliphatic C(sp3)-H bonds into a variety of C-C bonds is discussed. The methods disclosed include (a) C-H functionalizations of tertiary alkylamines and (b) α-heteroatom C-H thioetherification followed by alkylation with an organometallic species.III. Decarboxylative Homologation Using a Radical-Polar Conjunctive Reagent The development of one-carbon homologation of aliphatic carboxylic acids is discussed. Particular attention is paid to the iterative design of a two-carbon SOMOphile that was critical to achieving the desired synthon for the overall transformation.IV.Rapid Access to Α-Ketoesters via C-H and Decarboxylative Pyruvylation Alpha-ketoesters are regarded as highly diversifiable intermediates in organic synthesis, with numerous applications ranging from unnatural amino acid construction to heterocycle formation. A late-stage approach to installing these functional handles onto C(sp3)-H and carboxylic acid-containing molecules is discussed.
■590 ▼aSchool code: 0153.
■650 4▼aChemistry
■650 4▼aOrganic chemistry
■653 ▼aAliphatic carboxylic acids
■653 ▼aOrganometallic species
■653 ▼aThioetherification
■690 ▼a0485
■690 ▼a0490
■71020▼aThe University of North Carolina at Chapel Hill▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g86-11B.
■790 ▼a0153
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357010▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
