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How Simple Is Life? Kinematics of Morphogenesis in Embryo Development
How Simple Is Life? Kinematics of Morphogenesis in Embryo Development
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103611
- ISBN
- 9798291542507
- DDC
- 530
- 서명/저자
- How Simple Is Life? Kinematics of Morphogenesis in Embryo Development
- 발행사항
- [Sl] : University of California, Santa Barbara, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 174 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Streichan, Sebastian.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Santa Barbara, 2025.
- 초록/해제
- 요약During morphogenesis - the formation of shape in living matter - the interplay of genes and mechanics sculpts a multicellular organism. Biological 'atlases' of static samples that identify the molecular-scale genetic signatures of cells have been successful in illuminating connections between cell fates. A major open challenge is to connect fate analyses from static samples to shape changes revealed by live imaging - as even the kinematics of cells and tissues often remain unknown. To study these kinematics, this thesis develops a 'morphodynamic atlas' of development, a novel technique to synthesize multiple dynamic imaging datasets of an entire living animal into a single virtual coordinate system. Using atlas methods to characterize tissue flows on the entire surface of a complex model organism - the embryo of the fruit fly Drosophila melanogaster - reveals that its morphogenesis is organized into temporal 'modules' of quasi-stationary flow: surface flow patterns do not change, despite cells moving up to hundreds of cell radii. Genetic perturbations reveal that genes which break the spatial symmetry of the embryo's dorsal-ventral axis are a prerequisite for establishing stationary modules. Temperature perturbations, which perturb developmental rates, reveal a parameter-free scaling of flow speed which indicates that the embryo uses geometric information to determine the duration of a module. The morphodynamic atlas reveals an emergent simplicity in the kinematics of embryo development, and establishes a broadly-applicable framework for advancing physical understanding of the dynamics of complex living systems.
- 일반주제명
- Physics
- 일반주제명
- Biophysics
- 일반주제명
- Genetics
- 일반주제명
- Morphology
- 키워드
- Morphogenesis
- 키워드
- Kinematics
- 키워드
- Perturbations
- 기타저자
- University of California, Santa Barbara Physics
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■007cr#unu||||||||
■020 ▼a9798291542507
■035 ▼a(MiAaPQ)AAI32043347
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a530
■1001 ▼aJain-Sharma, Vishank.
■24510▼aHow Simple Is Life? Kinematics of Morphogenesis in Embryo Development
■260 ▼a[Sl]▼bUniversity of California, Santa Barbara▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a174 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Streichan, Sebastian.
■5021 ▼aThesis (Ph.D.)--University of California, Santa Barbara, 2025.
■520 ▼aDuring morphogenesis - the formation of shape in living matter - the interplay of genes and mechanics sculpts a multicellular organism. Biological 'atlases' of static samples that identify the molecular-scale genetic signatures of cells have been successful in illuminating connections between cell fates. A major open challenge is to connect fate analyses from static samples to shape changes revealed by live imaging - as even the kinematics of cells and tissues often remain unknown. To study these kinematics, this thesis develops a 'morphodynamic atlas' of development, a novel technique to synthesize multiple dynamic imaging datasets of an entire living animal into a single virtual coordinate system. Using atlas methods to characterize tissue flows on the entire surface of a complex model organism - the embryo of the fruit fly Drosophila melanogaster - reveals that its morphogenesis is organized into temporal 'modules' of quasi-stationary flow: surface flow patterns do not change, despite cells moving up to hundreds of cell radii. Genetic perturbations reveal that genes which break the spatial symmetry of the embryo's dorsal-ventral axis are a prerequisite for establishing stationary modules. Temperature perturbations, which perturb developmental rates, reveal a parameter-free scaling of flow speed which indicates that the embryo uses geometric information to determine the duration of a module. The morphodynamic atlas reveals an emergent simplicity in the kinematics of embryo development, and establishes a broadly-applicable framework for advancing physical understanding of the dynamics of complex living systems.
■590 ▼aSchool code: 0035.
■650 4▼aPhysics
■650 4▼aBiophysics
■650 4▼aGenetics
■650 4▼aMorphology
■653 ▼aDrosophila melanogaster
■653 ▼aMorphogenesis
■653 ▼aKinematics
■653 ▼aEmbryo development
■653 ▼aPerturbations
■690 ▼a0605
■690 ▼a0786
■690 ▼a0369
■690 ▼a0287
■71020▼aUniversity of California, Santa Barbara▼bPhysics.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0035
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17357870▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
