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Effects of Hydration Physiology on Aspects of the Gut-Brain Axis
Effects of Hydration Physiology on Aspects of the Gut-Brain Axis
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105208
- ISBN
- 9798291563557
- DDC
- 641
- 서명/저자
- Effects of Hydration Physiology on Aspects of the Gut-Brain Axis
- 발행사항
- [Sl] : University of Illinois at Urbana-Champaign, 2023
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2023
- 형태사항
- 141 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Holscher, Hannah D.;Khan, Naiman A.
- 학위논문주기
- Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2023.
- 초록/해제
- 요약Hydration status is an easy-to-measure marker of kidney and general health. This is important as most people in the United States are sub-optimally hydrated despite enjoying free access to safe drinking water. Water intake has been linked to aspects of metabolic syndrome (i.e., obesity, glucose regulation, hypertension), and cognitive performance; suggesting a role in maintaining metabolic and neural homeostasis. Indeed, one of the primary physiologic aims in water regulation is to maintain circulatory function via homeostatic blood volume, pressure, and concentration; fluctuations in which affect all organ systems in the body. Despite the known importance of water intake, it remains an understudied nutrient.This work has aimed to delineate the effects of variable water intake on cognitive and gastrointestinal function in humans through three primary aims: 1) how fecal microbial metabolites relate to specific domains of executive functioning; 2) relationships between fecal microbial abundance, markers of gut barrier integrity, and biomarkers of hydration status; and 3) how increasing plain water intake alters fecal microbiota community composition and impacts executive functioning in adults.These studies have revealed correlations between fecal butyrate concentration and inhibitory control in subjects with obesity, suggesting that fluctuations in gut saccharolytic fermentative activity may impact cognitive control in the context of metabolic disease. Further, these studies exposed relations between hydration biomarkers, fecal microbiota relative abundance, and circulating LPS in adults; indicating that modulations in water consumption may impact digestive homeostasis and microbiota community composition. Finally, a single-arm water intake intervention was conducted to further investigate these relationships longitudinally. The findings supported the established literature in demonstrating improvements in attention and memory abilities and subtle shifts in gastrointestinal microbiota relative abundance over the water intake intervention.While this work is hardly a comprehensive view of hydration physiology or the impact it has on the gut-brain axis, it shows the potential for water, as a relatively cheap and easily accessible nutrient, to modulate important aspects of the gut-brain axis. This is an area of research that warrants continued investigation.
- 일반주제명
- Nutrition
- 일반주제명
- Physiology
- 일반주제명
- Neurosciences
- 일반주제명
- Cognitive psychology
- 키워드
- Hydration
- 키워드
- Copeptin
- 키워드
- Gut microbiota
- 키워드
- Cognition
- 키워드
- Working memory
- 기타저자
- University of Illinois at Urbana-Champaign Nutritional Sciences
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■0820 ▼a641
■1001 ▼aWillis, Nathaniel Baldwin.
■24510▼aEffects of Hydration Physiology on Aspects of the Gut-Brain Axis
■260 ▼a[Sl]▼bUniversity of Illinois at Urbana-Champaign▼c2023
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2023
■300 ▼a141 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Holscher, Hannah D.;Khan, Naiman A.
■5021 ▼aThesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2023.
■520 ▼aHydration status is an easy-to-measure marker of kidney and general health. This is important as most people in the United States are sub-optimally hydrated despite enjoying free access to safe drinking water. Water intake has been linked to aspects of metabolic syndrome (i.e., obesity, glucose regulation, hypertension), and cognitive performance; suggesting a role in maintaining metabolic and neural homeostasis. Indeed, one of the primary physiologic aims in water regulation is to maintain circulatory function via homeostatic blood volume, pressure, and concentration; fluctuations in which affect all organ systems in the body. Despite the known importance of water intake, it remains an understudied nutrient.This work has aimed to delineate the effects of variable water intake on cognitive and gastrointestinal function in humans through three primary aims: 1) how fecal microbial metabolites relate to specific domains of executive functioning; 2) relationships between fecal microbial abundance, markers of gut barrier integrity, and biomarkers of hydration status; and 3) how increasing plain water intake alters fecal microbiota community composition and impacts executive functioning in adults.These studies have revealed correlations between fecal butyrate concentration and inhibitory control in subjects with obesity, suggesting that fluctuations in gut saccharolytic fermentative activity may impact cognitive control in the context of metabolic disease. Further, these studies exposed relations between hydration biomarkers, fecal microbiota relative abundance, and circulating LPS in adults; indicating that modulations in water consumption may impact digestive homeostasis and microbiota community composition. Finally, a single-arm water intake intervention was conducted to further investigate these relationships longitudinally. The findings supported the established literature in demonstrating improvements in attention and memory abilities and subtle shifts in gastrointestinal microbiota relative abundance over the water intake intervention.While this work is hardly a comprehensive view of hydration physiology or the impact it has on the gut-brain axis, it shows the potential for water, as a relatively cheap and easily accessible nutrient, to modulate important aspects of the gut-brain axis. This is an area of research that warrants continued investigation.
■590 ▼aSchool code: 0090.
■650 4▼aNutrition
■650 4▼aPhysiology
■650 4▼aNeurosciences
■650 4▼aCognitive psychology
■653 ▼aHydration
■653 ▼aCopeptin
■653 ▼aGut microbiota
■653 ▼aExecutive functions
■653 ▼aCognition
■653 ▼aWorking memory
■690 ▼a0570
■690 ▼a0317
■690 ▼a0633
■690 ▼a0719
■71020▼aUniversity of Illinois at Urbana-Champaign▼bNutritional Sciences.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0090
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359755▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
