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Exploring Sleep as a Window Into Neurodevelopment in 22q11.2 Deletion Syndrome
Exploring Sleep as a Window Into Neurodevelopment in 22q11.2 Deletion Syndrome
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104645
- ISBN
- 9798280758896
- DDC
- 616
- 서명/저자
- Exploring Sleep as a Window Into Neurodevelopment in 22q11.2 Deletion Syndrome
- 발행사항
- [Sl] : University of California, Los Angeles, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 127 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Bearden, Carrie E.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2025.
- 초록/해제
- 요약Sleep disturbance is common, impairing, and may affect symptomatology in neurodevelopmental psychiatric disorders (NPDs). Here, we take a genetics-first approach to study the complex role of sleep in psychopathology and neurodevelopment. Specifically, we examine severity of sleep disturbance, sleep physiology, and sleep-related behaviors in individuals with a deletion in the 22q11.2 locus (22qDel). A 22qDel confers some of the greatest known risks of neuropsychiatric disorders, including Autism Spectrum Disorder (ASD) and Schizophrenia. Despite the close relationship between sleep disturbances and NPDs, the literature on sleep in 22qDel carriers is scarce. This thesis aims to address gaps in the literature through conducting a series of studies that take a deep dive into different aspects of sleep in 22qDel carriers. We employ scalable methods of obtaining high-quality measures of sleep neurophysiology, including a newly developed sleep EEG headband, to adapt to the 22qDel population and cultivate a sample more representative of the 22qDel population. Our innovative studies utilizing new technology in a rare disorder, provide pilot data that serves as a starting point for investigating the mechanisms underlying the relationship between sleep and neurodevelopment in 22qDel carriers.
- 일반주제명
- Neurosciences
- 일반주제명
- Psychology
- 일반주제명
- Clinical psychology
- 키워드
- 22q11.2 locus
- 키워드
- Psychopathology
- 키워드
- Schizophrenia
- 기타저자
- University of California, Los Angeles Neuroscience 004F
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798280758896
■035 ▼a(MiAaPQ)AAI32114545
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aO'Hora, Kathleen Patricia.
■24510▼aExploring Sleep as a Window Into Neurodevelopment in 22q11.2 Deletion Syndrome
■260 ▼a[Sl]▼bUniversity of California, Los Angeles▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a127 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Bearden, Carrie E.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2025.
■520 ▼aSleep disturbance is common, impairing, and may affect symptomatology in neurodevelopmental psychiatric disorders (NPDs). Here, we take a genetics-first approach to study the complex role of sleep in psychopathology and neurodevelopment. Specifically, we examine severity of sleep disturbance, sleep physiology, and sleep-related behaviors in individuals with a deletion in the 22q11.2 locus (22qDel). A 22qDel confers some of the greatest known risks of neuropsychiatric disorders, including Autism Spectrum Disorder (ASD) and Schizophrenia. Despite the close relationship between sleep disturbances and NPDs, the literature on sleep in 22qDel carriers is scarce. This thesis aims to address gaps in the literature through conducting a series of studies that take a deep dive into different aspects of sleep in 22qDel carriers. We employ scalable methods of obtaining high-quality measures of sleep neurophysiology, including a newly developed sleep EEG headband, to adapt to the 22qDel population and cultivate a sample more representative of the 22qDel population. Our innovative studies utilizing new technology in a rare disorder, provide pilot data that serves as a starting point for investigating the mechanisms underlying the relationship between sleep and neurodevelopment in 22qDel carriers.
■590 ▼aSchool code: 0031.
■650 4▼aNeurosciences
■650 4▼aPsychology
■650 4▼aClinical psychology
■653 ▼aSleep disturbance
■653 ▼aNeurodevelopmental psychiatric disorders
■653 ▼a22q11.2 locus
■653 ▼aPsychopathology
■653 ▼aSchizophrenia
■690 ▼a0317
■690 ▼a0621
■690 ▼a0622
■71020▼aUniversity of California, Los Angeles▼bNeuroscience 004F.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358329▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
