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The Effects of Aggregation on Pathogen Transmission and Evolution
The Effects of Aggregation on Pathogen Transmission and Evolution
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104647
- ISBN
- 9798293893928
- DDC
- 574
- 서명/저자
- The Effects of Aggregation on Pathogen Transmission and Evolution
- 발행사항
- [Sl] : Princeton University, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 208 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-04, Section: B.
- 주기사항
- Advisor: Metcalf, C. Jessica E.
- 학위논문주기
- Thesis (Ph.D.)--Princeton University, 2025.
- 초록/해제
- 요약Aggregation of hosts is a ubiquitous feature within infectious disease systems: humans aggregate in households, schools, and workplaces, while wildlife and livestock animals aggregate into flocks, live market populations, as well as their own social clusters. Because aggregation is a fundamental part of the ecology of many hosts, it will affect the long-term transmission and evolution of pathogens within infectious disease systems. Additionally, it will affect the interventions we put in place to mitigate infection burden. In this dissertation, I address the effects of aggregation on the transmission and evolution of infectious diseases, as well as on intervention strategies. To address transmission, in the first chapter I model the effects of aggregation of poultry in village populations on Herd Immunity Thresholds of Newcastle disease virus, and in the second chapter the effects of the aggregation of evicted individuals into "doubled-up" households on transmission of COVID-19 in heterogeneous urban landscapes. To address evolution I ask how the aggregation of poultry across regions into live-animal markets will affect the long-term virulence evolution of avian pathogens, such as H5N1 avian influenza. Finally, to address interventions, I first develop causal inference methodology for field trials in order to assess the dependence of the protective effects of transmissible vaccines on aggregation, and second, investigate how to adequately power cluster randomized-control trials to estimate the effects of non-pharmaceutical interventions for places where humans normally aggregate, such as schools and workplaces. Identifying the role of aggregation allows us to better understand the host ecology of infectious disease systems, as well as design rational intervention strategies and policies to mitigate disease.
- 일반주제명
- Biology
- 일반주제명
- Ecology
- 일반주제명
- Pathology
- 일반주제명
- Evolution & development
- 키워드
- Aggregation
- 키워드
- Avian pathogens
- 기타저자
- Princeton University Ecology and Evolutionary Biology
- 기본자료저록
- Dissertations Abstracts International. 87-04B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202104647
■006m o d
■007cr#unu||||||||
■020 ▼a9798293893928
■035 ▼a(MiAaPQ)AAI32114704
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aSheen, Justin Kihyun.
■24510▼aThe Effects of Aggregation on Pathogen Transmission and Evolution
■260 ▼a[Sl]▼bPrinceton University▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a208 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-04, Section: B.
■500 ▼aAdvisor: Metcalf, C. Jessica E.
■5021 ▼aThesis (Ph.D.)--Princeton University, 2025.
■520 ▼aAggregation of hosts is a ubiquitous feature within infectious disease systems: humans aggregate in households, schools, and workplaces, while wildlife and livestock animals aggregate into flocks, live market populations, as well as their own social clusters. Because aggregation is a fundamental part of the ecology of many hosts, it will affect the long-term transmission and evolution of pathogens within infectious disease systems. Additionally, it will affect the interventions we put in place to mitigate infection burden. In this dissertation, I address the effects of aggregation on the transmission and evolution of infectious diseases, as well as on intervention strategies. To address transmission, in the first chapter I model the effects of aggregation of poultry in village populations on Herd Immunity Thresholds of Newcastle disease virus, and in the second chapter the effects of the aggregation of evicted individuals into "doubled-up" households on transmission of COVID-19 in heterogeneous urban landscapes. To address evolution I ask how the aggregation of poultry across regions into live-animal markets will affect the long-term virulence evolution of avian pathogens, such as H5N1 avian influenza. Finally, to address interventions, I first develop causal inference methodology for field trials in order to assess the dependence of the protective effects of transmissible vaccines on aggregation, and second, investigate how to adequately power cluster randomized-control trials to estimate the effects of non-pharmaceutical interventions for places where humans normally aggregate, such as schools and workplaces. Identifying the role of aggregation allows us to better understand the host ecology of infectious disease systems, as well as design rational intervention strategies and policies to mitigate disease.
■590 ▼aSchool code: 0181.
■650 4▼aBiology
■650 4▼aEcology
■650 4▼aPathology
■650 4▼aEvolution & development
■653 ▼aAggregation
■653 ▼aInfectious disease systems
■653 ▼aAvian pathogens
■690 ▼a0306
■690 ▼a0412
■690 ▼a0329
■690 ▼a0571
■71020▼aPrinceton University▼bEcology and Evolutionary Biology.
■7730 ▼tDissertations Abstracts International▼g87-04B.
■790 ▼a0181
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358343▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
