서브메뉴
검색
Theoretical and Computational Investigations of Membrane Associated Molecular Pathology
Theoretical and Computational Investigations of Membrane Associated Molecular Pathology
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105211
- ISBN
- 9798291563915
- DDC
- 574.191
- 서명/저자
- Theoretical and Computational Investigations of Membrane Associated Molecular Pathology
- 발행사항
- [Sl] : University of Illinois at Urbana-Champaign, 2023
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2023
- 형태사항
- 222 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Tajkhorshid, Emad.
- 학위논문주기
- Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2023.
- 초록/해제
- 요약In this work we investigations membrane associated molecular pathology via a theoretical and computational approach. This work explores the use of mathematical tools from topology and molecular simulations to study membranes. These systems include amyloid beta, amphotericin, PPAR, CYP2J2, and fusion proteins. For amyloid beta, we investigate membrane destabilization and pore formation responsible for pathology in Alzheimer's disease. We probe biophysical properties of amphotericin to develop more clinically relevant fungicides. For CYP2J2, we study the mechanisms for metabolism and signaling relevant to cancer. In PPAR, the role of plasticizers are scrutinized for endocrine response. In addition, fusion and transport mechanisms are probed in the context of SNARE proteins and their priming partners. Overall, the role of membranes and boundaries are explored in molecular pathology.
- 일반주제명
- Biophysics
- 일반주제명
- Oncology
- 일반주제명
- Pathology
- 일반주제명
- Molecular biology
- 키워드
- Membranes
- 키워드
- Topology
- 키워드
- Amphotericin
- 키워드
- Fusion proteins
- 키워드
- Cancer
- 기타저자
- University of Illinois at Urbana-Champaign School of Molecular & Cell Bio
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2023 us c eng d■001000017359773
■00520260202105211
■006m o d
■007cr#unu||||||||
■020 ▼a9798291563915
■035 ▼a(MiAaPQ)AAI32271375
■035 ▼a(MiAaPQ)httphdlhandlenet2142121521
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574.191
■1001 ▼aArango, Andres Santiago.
■24510▼aTheoretical and Computational Investigations of Membrane Associated Molecular Pathology
■260 ▼a[Sl]▼bUniversity of Illinois at Urbana-Champaign▼c2023
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2023
■300 ▼a222 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Tajkhorshid, Emad.
■5021 ▼aThesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2023.
■520 ▼aIn this work we investigations membrane associated molecular pathology via a theoretical and computational approach. This work explores the use of mathematical tools from topology and molecular simulations to study membranes. These systems include amyloid beta, amphotericin, PPAR, CYP2J2, and fusion proteins. For amyloid beta, we investigate membrane destabilization and pore formation responsible for pathology in Alzheimer's disease. We probe biophysical properties of amphotericin to develop more clinically relevant fungicides. For CYP2J2, we study the mechanisms for metabolism and signaling relevant to cancer. In PPAR, the role of plasticizers are scrutinized for endocrine response. In addition, fusion and transport mechanisms are probed in the context of SNARE proteins and their priming partners. Overall, the role of membranes and boundaries are explored in molecular pathology.
■590 ▼aSchool code: 0090.
■650 4▼aBiophysics
■650 4▼aOncology
■650 4▼aPathology
■650 4▼aMolecular biology
■653 ▼aMembranes
■653 ▼aTopology
■653 ▼aMolecular simulations
■653 ▼aAmphotericin
■653 ▼aFusion proteins
■653 ▼aMembrane destabilization
■653 ▼aAlzheimer's disease
■653 ▼aCancer
■653 ▼aEndocrine response
■690 ▼a0786
■690 ▼a0992
■690 ▼a0307
■690 ▼a0571
■71020▼aUniversity of Illinois at Urbana-Champaign▼bSchool of Molecular & Cell Bio.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0090
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359773▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
