서브메뉴
검색
Bridging the Gaps in Gynecologic Cancers: Prevention and Survival
Bridging the Gaps in Gynecologic Cancers: Prevention and Survival
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105213
- ISBN
- 9798291564745
- DDC
- 614
- 저자명
- Khoja, Lilah.
- 서명/저자
- Bridging the Gaps in Gynecologic Cancers: Prevention and Survival
- 발행사항
- [Sl] : University of Michigan, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 196 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Pearce, Celeste Leigh.
- 학위논문주기
- Thesis (Ph.D.)--University of Michigan, 2025.
- 초록/해제
- 요약This dissertation examines prevention strategies for two types of gynecologic cancers: cervical and ovarian. It delves into secondary prevention of cervical cancer through both qualitative and quantitative methods and investigates tertiary prevention of ovarian cancer using quantitative approaches. For cervical cancer, research was conducted under the Human Papillomavirus (HPV) component of the Study of Arab American Health Attitudes (SAHA). In Aim 1, focus groups were held in Michigan with Arab American and Chaldean women (n=19). The study revealed low cervical cancer screening rates in this population, attributed to negative perceptions of screening, scheduling challenges, and lack of awareness about cancer prevention. Participants had mixed feelings about HPV self-collection outside medical settings, like at home. Aim 2 involved both qualitative and quantitative methods in an expanded SAHA-HPV study that included Arab American and Chaldean women from Southern California, Chicago, Illinois, and the New York City metropolitan area. Focus groups were conducted in these areas, and a broader quantitative survey was available to Arab and Chaldean women in all these regions and Michigan. This survey included questions about demographics, health behaviors, attitudes towards cancer screening, and knowledge about cervical cancer and HPV. The study found moderate awareness of HPV and cervical cancer risk factors but a lack of tailored health education and interventions for Arab American women. Focus group participants (n=22) showed some knowledge about cervical cancer and HPV, with mixed feelings about HPV self-sampling. Among questionnaire respondents (n=25), 94% were current with screening. While 59% favored self-sampling at home, concerns about the accuracy were prevalent. The disparity in screening rates between Arab American women and other groups indicates an urgent need for culturally tailored health education and interventions. Aim 3 evaluated the acceptability and feasibility of HPV self-sampling in Bangladesh, where cervical cancer is a significant health risk. Women at a health clinic in Araihazar Upazila participated in the study (n=164). High levels of cervical cancer awareness were observed, but specific knowledge about causes was low. Over 95% of participants expressed willingness to self-sample again, highlighting an opportunity to improve screening rates and early detection through increased education and awareness. Although secondary prevention is critical in reducing cervical cancer burden, there is no effective screening for invasive epithelial ovarian cancer. Therefore, tertiary prevention is vital. In Aim 4, factors affecting long-term survival (10+ years) compared to short-term survival (2-4.99 years) in advanced-stage high-grade serous ovarian cancer were analyzed using data from the Multidisciplinary Ovarian Cancer Outcomes Group. The study identified pathogenic variants in BRCA2 and related genes, immunologic markers, and optimal primary cytoreductive surgery as factors independently associated with long-term survival. Non-smoking history also correlated with better outcomes, laying the groundwork for improving survival rates. Overall, this dissertation highlights strategies to lessen the burden of these gynecologic cancers. In Arab and Chaldean American populations, culturally tailored cervical cancer education shows promise in reducing disease burden. HPV self-sampling emerged as a practical strategy for overcoming screening barriers in Bangladesh. Identifying factors associated with long-term survival in ovarian cancer could lead to improved outcomes for affected women.
- 일반주제명
- Public health
- 일반주제명
- Epidemiology
- 일반주제명
- Oncology
- 일반주제명
- Obstetrics
- 일반주제명
- Immunology
- 키워드
- Cervical cancer
- 키워드
- Ovarian cancer
- 기타저자
- University of Michigan Epidemiological Science
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2025 us c eng d■001000017359783
■00520260202105213
■006m o d
■007cr#unu||||||||
■020 ▼a9798291564745
■035 ▼a(MiAaPQ)AAI32271727
■035 ▼a(MiAaPQ)umichrackham006381
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a614
■1001 ▼aKhoja, Lilah.
■24510▼aBridging the Gaps in Gynecologic Cancers: Prevention and Survival
■260 ▼a[Sl]▼bUniversity of Michigan▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a196 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Pearce, Celeste Leigh.
■5021 ▼aThesis (Ph.D.)--University of Michigan, 2025.
■520 ▼aThis dissertation examines prevention strategies for two types of gynecologic cancers: cervical and ovarian. It delves into secondary prevention of cervical cancer through both qualitative and quantitative methods and investigates tertiary prevention of ovarian cancer using quantitative approaches. For cervical cancer, research was conducted under the Human Papillomavirus (HPV) component of the Study of Arab American Health Attitudes (SAHA). In Aim 1, focus groups were held in Michigan with Arab American and Chaldean women (n=19). The study revealed low cervical cancer screening rates in this population, attributed to negative perceptions of screening, scheduling challenges, and lack of awareness about cancer prevention. Participants had mixed feelings about HPV self-collection outside medical settings, like at home. Aim 2 involved both qualitative and quantitative methods in an expanded SAHA-HPV study that included Arab American and Chaldean women from Southern California, Chicago, Illinois, and the New York City metropolitan area. Focus groups were conducted in these areas, and a broader quantitative survey was available to Arab and Chaldean women in all these regions and Michigan. This survey included questions about demographics, health behaviors, attitudes towards cancer screening, and knowledge about cervical cancer and HPV. The study found moderate awareness of HPV and cervical cancer risk factors but a lack of tailored health education and interventions for Arab American women. Focus group participants (n=22) showed some knowledge about cervical cancer and HPV, with mixed feelings about HPV self-sampling. Among questionnaire respondents (n=25), 94% were current with screening. While 59% favored self-sampling at home, concerns about the accuracy were prevalent. The disparity in screening rates between Arab American women and other groups indicates an urgent need for culturally tailored health education and interventions. Aim 3 evaluated the acceptability and feasibility of HPV self-sampling in Bangladesh, where cervical cancer is a significant health risk. Women at a health clinic in Araihazar Upazila participated in the study (n=164). High levels of cervical cancer awareness were observed, but specific knowledge about causes was low. Over 95% of participants expressed willingness to self-sample again, highlighting an opportunity to improve screening rates and early detection through increased education and awareness. Although secondary prevention is critical in reducing cervical cancer burden, there is no effective screening for invasive epithelial ovarian cancer. Therefore, tertiary prevention is vital. In Aim 4, factors affecting long-term survival (10+ years) compared to short-term survival (2-4.99 years) in advanced-stage high-grade serous ovarian cancer were analyzed using data from the Multidisciplinary Ovarian Cancer Outcomes Group. The study identified pathogenic variants in BRCA2 and related genes, immunologic markers, and optimal primary cytoreductive surgery as factors independently associated with long-term survival. Non-smoking history also correlated with better outcomes, laying the groundwork for improving survival rates. Overall, this dissertation highlights strategies to lessen the burden of these gynecologic cancers. In Arab and Chaldean American populations, culturally tailored cervical cancer education shows promise in reducing disease burden. HPV self-sampling emerged as a practical strategy for overcoming screening barriers in Bangladesh. Identifying factors associated with long-term survival in ovarian cancer could lead to improved outcomes for affected women.
■590 ▼aSchool code: 0127.
■650 4▼aPublic health
■650 4▼aEpidemiology
■650 4▼aOncology
■650 4▼aObstetrics
■650 4▼aImmunology
■653 ▼aArab American health
■653 ▼aCancer epidemiology
■653 ▼aCervical cancer
■653 ▼aOvarian cancer
■653 ▼aHuman Papillomavirus
■690 ▼a0766
■690 ▼a0573
■690 ▼a0992
■690 ▼a0982
■690 ▼a0380
■71020▼aUniversity of Michigan▼bEpidemiological Science.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0127
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359783▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.


