서브메뉴
검색
Keratin 13 Marks a Hillock-Like State in Squamous Lung Cancer
Keratin 13 Marks a Hillock-Like State in Squamous Lung Cancer
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202102958
- ISBN
- 9798293831937
- DDC
- 616.99
- 저자명
- Reyes, Tony.
- 서명/저자
- Keratin 13 Marks a Hillock-Like State in Squamous Lung Cancer
- 발행사항
- [Sl] : The University of Utah, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 136 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-03, Section: B.
- 주기사항
- Includes supplementary digital materials.
- 주기사항
- Advisor: Oliver, Trudy G.
- 학위논문주기
- Thesis (D.Phil.)--The University of Utah, 2025.
- 초록/해제
- 요약Lung squamous cell carcinoma (LUSC) is a major subtype of non-small cell lung cancer with limited treatment options. A distinct tumor-propagating cell (TPC) state that resembles normal basal cells has previously been identified within squamous tumors. We report that squamous tumors display unappreciated levels of intra-tumoral heterogeneity and harbor states distinct from the previously reported TPC state. We found that Krt13+ tumor cells represent a subpopulation of non-proliferative squamous tumor cells not found in other subtypes of lung cancer. Importantly, we discovered that KRT13 marks a hillock-like state in squamous tumors that displays signatures of immunomodulation. Importantly, we noticed that the hillock-like state is enriched in tumors initiated in club cells, consistent with normal developmental processes during regeneration of club cells. Within squamous tumors, we discovered that tumor-propagating cells can give rise to this newly identified Krt13+ hillock-like tumor cell subpopulation. This newly identified subpopulation may be regulated by KLF4 expression and highly produces the hillock-specific immunomodulator LGALS3. These findings provide important context into the tumor heterogeneity and plasticity displayed by squamous tumors.
- 일반주제명
- Oncology
- 일반주제명
- Cellular biology
- 일반주제명
- Health sciences
- 키워드
- Immunomodulator
- 기타저자
- The University of Utah Oncological Sciences
- 기본자료저록
- Dissertations Abstracts International. 87-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2025 us c eng d■001000017356588
■00520260202102958
■006m o d
■007cr#unu||||||||
■020 ▼a9798293831937
■035 ▼a(MiAaPQ)AAI31770665
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616.99
■1001 ▼aReyes, Tony.
■24510▼aKeratin 13 Marks a Hillock-Like State in Squamous Lung Cancer
■260 ▼a[Sl]▼bThe University of Utah▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a136 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-03, Section: B.
■500 ▼aIncludes supplementary digital materials.
■500 ▼aAdvisor: Oliver, Trudy G.
■5021 ▼aThesis (D.Phil.)--The University of Utah, 2025.
■520 ▼aLung squamous cell carcinoma (LUSC) is a major subtype of non-small cell lung cancer with limited treatment options. A distinct tumor-propagating cell (TPC) state that resembles normal basal cells has previously been identified within squamous tumors. We report that squamous tumors display unappreciated levels of intra-tumoral heterogeneity and harbor states distinct from the previously reported TPC state. We found that Krt13+ tumor cells represent a subpopulation of non-proliferative squamous tumor cells not found in other subtypes of lung cancer. Importantly, we discovered that KRT13 marks a hillock-like state in squamous tumors that displays signatures of immunomodulation. Importantly, we noticed that the hillock-like state is enriched in tumors initiated in club cells, consistent with normal developmental processes during regeneration of club cells. Within squamous tumors, we discovered that tumor-propagating cells can give rise to this newly identified Krt13+ hillock-like tumor cell subpopulation. This newly identified subpopulation may be regulated by KLF4 expression and highly produces the hillock-specific immunomodulator LGALS3. These findings provide important context into the tumor heterogeneity and plasticity displayed by squamous tumors.
■590 ▼aSchool code: 0240.
■650 4▼aOncology
■650 4▼aCellular biology
■650 4▼aHealth sciences
■653 ▼aHillock-like state
■653 ▼aLung squamous cell carcinoma
■653 ▼aImmunomodulator
■690 ▼a0992
■690 ▼a0566
■690 ▼a0379
■71020▼aThe University of Utah▼bOncological Sciences.
■7730 ▼tDissertations Abstracts International▼g87-03B.
■790 ▼a0240
■791 ▼aD.Phil.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17356588▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
