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The Involvement of the Cerebellum in Sensory Over-Responsivity in Autism
The Involvement of the Cerebellum in Sensory Over-Responsivity in Autism
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202103633
- ISBN
- 9798315793144
- DDC
- 616
- 서명/저자
- The Involvement of the Cerebellum in Sensory Over-Responsivity in Autism
- 발행사항
- [Sl] : University of California, Los Angeles, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 187 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
- 주기사항
- Advisor: Dapretto, Mirella;Green, Shulamite Abra.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2025.
- 초록/해제
- 요약The cerebellum plays a key role in sensorimotor coordination and has been repeatedly reported to be structurally and functionally altered in individuals with autism spectrum disorder (ASD). Atypicalities in the ASD cerebellum have also been linked to multiple ASD symptoms, including general sensory processing atypicalities. The vast majority of autistic youth have sensory processing atypicalities, with sensory over-responsivity (SOR) in particular being a common challenge to their quality of life. SOR has been associated with poor social adaptive, emotional and daily-life skills. Despite its impairing effect on the daily functioning of children with ASD, there are currently few evidence-based treatments for SOR. While cerebellar atypicalities may have direct links with SOR symptoms, to our knowledge, no studies previously investigated the link between cerebellar function and SOR in ASD. In the current dissertation study, I examined the role of cerebellar function in autistic youth with varying degrees of SOR. In three studies, I characterized functional alterations in the ASD cerebellum at rest (Study 1) and during sensory exposure (Studies 2 and 3), and investigated how these atypicalities relate to SOR. Moreover, I interrogated associations between cerebellar function during sensory stimulation and previously identified neural markers of SOR, sensory-limbic habituation (Study 2) and thalamic inhibition (Study 3). My findings implicate cerebellar atypicalities in the neural basis of SOR symptoms in ASD youth. Characterizing the neural basis of SOR is an important step towards formulating effective interventions to improve the everyday lives of children with ASD who experience SOR and ensuring that treatment is personalized based on individual differences in ASD-related symptomatology.
- 일반주제명
- Neurosciences
- 일반주제명
- Developmental psychology
- 일반주제명
- Cognitive psychology
- 키워드
- Cerebellum
- 기타저자
- University of California, Los Angeles Neuroscience 004F
- 기본자료저록
- Dissertations Abstracts International. 86-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798315793144
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■040 ▼aMiAaPQ▼cMiAaPQ
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■1001 ▼aCakar, Melis Ezgi.
■24510▼aThe Involvement of the Cerebellum in Sensory Over-Responsivity in Autism
■260 ▼a[Sl]▼bUniversity of California, Los Angeles▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a187 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-12, Section: B.
■500 ▼aAdvisor: Dapretto, Mirella;Green, Shulamite Abra.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2025.
■520 ▼aThe cerebellum plays a key role in sensorimotor coordination and has been repeatedly reported to be structurally and functionally altered in individuals with autism spectrum disorder (ASD). Atypicalities in the ASD cerebellum have also been linked to multiple ASD symptoms, including general sensory processing atypicalities. The vast majority of autistic youth have sensory processing atypicalities, with sensory over-responsivity (SOR) in particular being a common challenge to their quality of life. SOR has been associated with poor social adaptive, emotional and daily-life skills. Despite its impairing effect on the daily functioning of children with ASD, there are currently few evidence-based treatments for SOR. While cerebellar atypicalities may have direct links with SOR symptoms, to our knowledge, no studies previously investigated the link between cerebellar function and SOR in ASD. In the current dissertation study, I examined the role of cerebellar function in autistic youth with varying degrees of SOR. In three studies, I characterized functional alterations in the ASD cerebellum at rest (Study 1) and during sensory exposure (Studies 2 and 3), and investigated how these atypicalities relate to SOR. Moreover, I interrogated associations between cerebellar function during sensory stimulation and previously identified neural markers of SOR, sensory-limbic habituation (Study 2) and thalamic inhibition (Study 3). My findings implicate cerebellar atypicalities in the neural basis of SOR symptoms in ASD youth. Characterizing the neural basis of SOR is an important step towards formulating effective interventions to improve the everyday lives of children with ASD who experience SOR and ensuring that treatment is personalized based on individual differences in ASD-related symptomatology.
■590 ▼aSchool code: 0031.
■650 4▼aNeurosciences
■650 4▼aDevelopmental psychology
■650 4▼aCognitive psychology
■653 ▼aAutism spectrum disorder
■653 ▼aCerebellum
■653 ▼aSensory over-responsivity
■653 ▼aSensorimotor coordination
■690 ▼a0317
■690 ▼a0620
■690 ▼a0633
■71020▼aUniversity of California, Los Angeles▼bNeuroscience 004F.
■7730 ▼tDissertations Abstracts International▼g86-12B.
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358027▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
