서브메뉴
검색
Lymphatic Chain Gradients Regulate the Magnitude and Heterogeneity of T Cell Responses to Vaccination
Lymphatic Chain Gradients Regulate the Magnitude and Heterogeneity of T Cell Responses to Vaccination
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202104650
- ISBN
- 9798288833106
- DDC
- 616.079
- 서명/저자
- Lymphatic Chain Gradients Regulate the Magnitude and Heterogeneity of T Cell Responses to Vaccination
- 발행사항
- [Sl] : University of Washington, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 96 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-01, Section: B.
- 주기사항
- Advisor: Gerner, Michael Y.
- 학위논문주기
- Thesis (Ph.D.)--University of Washington, 2025.
- 초록/해제
- 요약Upon activation, T cells proliferate and differentiate into diverse populations, including highly differentiated effector and memory precursor subsets. Initial diversification is influenced by signals sensed during T cell priming within lymphoid tissues. However, the rules governing how cellular heterogeneity is spatially encoded in vivo remain unclear. Here, we show that immunization establishes concentration gradients of antigens and inflammation across interconnected chains of draining lymph nodes (IC-LNs). While T cells are activated at all sites, individual IC-LNs elicit divergent responses: proximal IC-LNs favor the generation of effector cells, whereas distal IC-LNs promote formation of central memory precursor cells. Although both proximal and distal sites contribute to anamnestic responses, T cells from proximal IC-LNs preferentially provide early effector responses at inflamed tissues. Conversely, T cells from distal IC-LNs demonstrate an enhanced capacity to generate long-lasting responses to chronic antigens in cancer settings, including after checkpoint blockade therapy. Therefore, formation of spatial gradients across lymphatic chains following vaccination regulates the magnitude, heterogeneity, and longevity of T cell responses.
- 일반주제명
- Immunology
- 일반주제명
- Medicine
- 일반주제명
- Oncology
- 키워드
- Lymphatics
- 키워드
- T cell biology
- 키워드
- Vaccines
- 기타저자
- University of Washington Immunology
- 기본자료저록
- Dissertations Abstracts International. 87-01B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008260126s2025 us c eng d■001000017358367
■00520260202104650
■006m o d
■007cr#unu||||||||
■020 ▼a9798288833106
■035 ▼a(MiAaPQ)AAI32115278
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616.079
■1001 ▼aConlon, Michael T.
■24510▼aLymphatic Chain Gradients Regulate the Magnitude and Heterogeneity of T Cell Responses to Vaccination
■260 ▼a[Sl]▼bUniversity of Washington▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a96 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-01, Section: B.
■500 ▼aAdvisor: Gerner, Michael Y.
■5021 ▼aThesis (Ph.D.)--University of Washington, 2025.
■520 ▼aUpon activation, T cells proliferate and differentiate into diverse populations, including highly differentiated effector and memory precursor subsets. Initial diversification is influenced by signals sensed during T cell priming within lymphoid tissues. However, the rules governing how cellular heterogeneity is spatially encoded in vivo remain unclear. Here, we show that immunization establishes concentration gradients of antigens and inflammation across interconnected chains of draining lymph nodes (IC-LNs). While T cells are activated at all sites, individual IC-LNs elicit divergent responses: proximal IC-LNs favor the generation of effector cells, whereas distal IC-LNs promote formation of central memory precursor cells. Although both proximal and distal sites contribute to anamnestic responses, T cells from proximal IC-LNs preferentially provide early effector responses at inflamed tissues. Conversely, T cells from distal IC-LNs demonstrate an enhanced capacity to generate long-lasting responses to chronic antigens in cancer settings, including after checkpoint blockade therapy. Therefore, formation of spatial gradients across lymphatic chains following vaccination regulates the magnitude, heterogeneity, and longevity of T cell responses.
■590 ▼aSchool code: 0250.
■650 4▼aImmunology
■650 4▼aMedicine
■650 4▼aOncology
■653 ▼aAdaptive immunity
■653 ▼aCancer immunology
■653 ▼aLymph node biology
■653 ▼aLymphatics
■653 ▼aT cell biology
■653 ▼aVaccines
■690 ▼a0982
■690 ▼a0564
■690 ▼a0992
■71020▼aUniversity of Washington▼bImmunology.
■7730 ▼tDissertations Abstracts International▼g87-01B.
■790 ▼a0250
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17358367▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
