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Novel X-Ray Detectors and Applications in Medical Imaging
Novel X-Ray Detectors and Applications in Medical Imaging
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20260202105101
- ISBN
- 9798291547038
- DDC
- 616
- 서명/저자
- Novel X-Ray Detectors and Applications in Medical Imaging
- 발행사항
- [Sl] : The University of Wisconsin - Madison, 2025
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2025
- 형태사항
- 118 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
- 주기사항
- Advisor: Chen, Guang-Hong.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
- 초록/해제
- 요약The x-ray detector is a critical component for advancing medical imaging. However, many state-of-the-art detectors face fundamental trade-offs that limit performance in specific clinical applications. For example, the performance of deep-silicon photon-counting detectors (Si-PCDs) is compromised by its low atomic number introducing significant prevalence of x-ray scatter interactions, which degrades dose efficiency. Similarly, conventional dual-layer flat-panel detectors (DL-FPDs) utilize a permanent inter-layer filter to provide the spectral separation required for effective for dual-energy (DE) imaging; however, they suffer from reduced dose efficiency in more common single-energy (SE) acquisitions, impairing their versatility. Furthermore, a significant barrier to online adaptive proton therapy (OAPT) is the lack of on-board imaging systems capable of providing the quantitative accuracy needed for treatment planning.This work addresses these distinct challenges by developing, implementing, and evaluating three novel detector architectures or novel applications of state-of-the-art detectors. To mitigate scatter in Si-PCDs, a Si-scintillator hybrid architecture was proposed, and its feasibility for recovering lost signal while reducing inter-detector row crosstalk was demonstrated through proof-of-concept experiments and simulations. To improve the versatility of DL-FPDs, a design featuring a removable inter-layer filter was introduced; theoretical optimizations and experimental studies showed this design significantly improves SE dose efficiency and allows for enhanced DE performance by tailoring the filter to the imaging task. Finally, to enable quantitative image guidance for OAPT, a prototype PCD-based CT system was successfully integrated onto a clinical proton therapy gantry. This work included the development of custom mounting hardware and an external triggering system, and use of comprehensive calibrations. Subsequent evaluations confirmed the system's stability and demonstrated superior image quality compared to the existing on-board FPD and accurate stopping power ratio (SPR) quantification.Collectively, the hardware and methods presented provide innovative and practical solutions to existing detector performance trade-offs, with the potential to improve diagnostic quality and therapeutic accuracy across a range of medical imaging applications.
- 일반주제명
- Medical imaging
- 일반주제명
- Biomedical engineering
- 일반주제명
- Physics
- 일반주제명
- Energy
- 키워드
- Dual-energy
- 키워드
- Single-energy
- 기타저자
- The University of Wisconsin - Madison Medical Physics
- 기본자료저록
- Dissertations Abstracts International. 87-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520260202105101
■006m o d
■007cr#unu||||||||
■020 ▼a9798291547038
■035 ▼a(MiAaPQ)AAI32235968
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aDe Caro, Christian.
■24510▼aNovel X-Ray Detectors and Applications in Medical Imaging
■260 ▼a[Sl]▼bThe University of Wisconsin - Madison▼c2025
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2025
■300 ▼a118 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 87-02, Section: B.
■500 ▼aAdvisor: Chen, Guang-Hong.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2025.
■520 ▼aThe x-ray detector is a critical component for advancing medical imaging. However, many state-of-the-art detectors face fundamental trade-offs that limit performance in specific clinical applications. For example, the performance of deep-silicon photon-counting detectors (Si-PCDs) is compromised by its low atomic number introducing significant prevalence of x-ray scatter interactions, which degrades dose efficiency. Similarly, conventional dual-layer flat-panel detectors (DL-FPDs) utilize a permanent inter-layer filter to provide the spectral separation required for effective for dual-energy (DE) imaging; however, they suffer from reduced dose efficiency in more common single-energy (SE) acquisitions, impairing their versatility. Furthermore, a significant barrier to online adaptive proton therapy (OAPT) is the lack of on-board imaging systems capable of providing the quantitative accuracy needed for treatment planning.This work addresses these distinct challenges by developing, implementing, and evaluating three novel detector architectures or novel applications of state-of-the-art detectors. To mitigate scatter in Si-PCDs, a Si-scintillator hybrid architecture was proposed, and its feasibility for recovering lost signal while reducing inter-detector row crosstalk was demonstrated through proof-of-concept experiments and simulations. To improve the versatility of DL-FPDs, a design featuring a removable inter-layer filter was introduced; theoretical optimizations and experimental studies showed this design significantly improves SE dose efficiency and allows for enhanced DE performance by tailoring the filter to the imaging task. Finally, to enable quantitative image guidance for OAPT, a prototype PCD-based CT system was successfully integrated onto a clinical proton therapy gantry. This work included the development of custom mounting hardware and an external triggering system, and use of comprehensive calibrations. Subsequent evaluations confirmed the system's stability and demonstrated superior image quality compared to the existing on-board FPD and accurate stopping power ratio (SPR) quantification.Collectively, the hardware and methods presented provide innovative and practical solutions to existing detector performance trade-offs, with the potential to improve diagnostic quality and therapeutic accuracy across a range of medical imaging applications.
■590 ▼aSchool code: 0262.
■650 4▼aMedical imaging
■650 4▼aBiomedical engineering
■650 4▼aPhysics
■650 4▼aEnergy
■653 ▼aDual-energy
■653 ▼aPhoton-counting detectors
■653 ▼aSingle-energy
■653 ▼aOnline adaptive proton therapy
■653 ▼aStopping power ratio
■690 ▼a0574
■690 ▼a0541
■690 ▼a0605
■690 ▼a0791
■71020▼aThe University of Wisconsin - Madison▼bMedical Physics.
■7730 ▼tDissertations Abstracts International▼g87-02B.
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2025
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17359321▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
